Obeticholic acid and ferrostatin-1 differentially ameliorate non-alcoholic steatohepatitis in AMLN diet-fed ob/ob mice

Obeticholic acid and ferrostatin-1 differentially ameliorate non-alcoholic steatohepatitis in AMLN diet-fed ob/ob mice

Introduction: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are common chronic liver diseases with limited treatment options.Methods: Ob/ob mice (6 weeks old) were fed with the Control diet or amylin liver NASH (AMLN) diet for 24 weeks to establish the NASH, the...

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Main Authors: Shengjie Li, Aoxiang Zhuge, Kaicen Wang, Jiafeng Xia, Qiangqiang Wang, Shengyi Han, Jian Shen, Lanjuan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Pharmacology
Subjects:
obeticholic acid
ferrostatin-1
steatohepatitis
oxidative stress
fibrosis
microbiome
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1081553/full

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