Total Syntheses of Telisatin A, Telisatin B and Lettowianthine
Treatment of 1-(2-bromoarylmethyl)-3,4-dihydroisoquinolines with oxalyl chloride and triethylamine gave 1-(2-bromophenyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2,3-dione derivatives, for example, 1-(2-bromophenyl)-5,6-dihydro-8,9-dimethoxypyrrolo[2,1-a]isoquinoline-2,3-dione. Radical cyclisation of...
| Format: | Article |
|---|---|
| Language: | English |
| Published: |
MDPI AG
2009-02-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/14/3/917/ |
| _version_ | 1818064339317293056 |
|---|---|
| collection | DOAJ |
| description | Treatment of 1-(2-bromoarylmethyl)-3,4-dihydroisoquinolines with oxalyl chloride and triethylamine gave 1-(2-bromophenyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2,3-dione derivatives, for example, 1-(2-bromophenyl)-5,6-dihydro-8,9-dimethoxypyrrolo[2,1-a]isoquinoline-2,3-dione. Radical cyclisation of these derivatives with tributyltin hydride and 1,1-azobis(cyclohexanecarbonitrile) afforded telisatin A, telisatin B and lettowianthine. |
| first_indexed | 2024-12-10T14:34:25Z |
| format | Article |
| id | doaj.art-4681e0f1e1694ab7ae4b820e6376ccf4 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-10T14:34:25Z |
| publishDate | 2009-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4681e0f1e1694ab7ae4b820e6376ccf42022-12-22T01:44:51ZengMDPI AGMolecules1420-30492009-02-0114391792410.3390/molecules14030917Total Syntheses of Telisatin A, Telisatin B and LettowianthineTreatment of 1-(2-bromoarylmethyl)-3,4-dihydroisoquinolines with oxalyl chloride and triethylamine gave 1-(2-bromophenyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2,3-dione derivatives, for example, 1-(2-bromophenyl)-5,6-dihydro-8,9-dimethoxypyrrolo[2,1-a]isoquinoline-2,3-dione. Radical cyclisation of these derivatives with tributyltin hydride and 1,1-azobis(cyclohexanecarbonitrile) afforded telisatin A, telisatin B and lettowianthine.http://www.mdpi.com/1420-3049/14/3/917/AlkaloidDioxoaporphineIsoquinolineRadical cyclisationSynthesis |
| spellingShingle | Total Syntheses of Telisatin A, Telisatin B and Lettowianthine Molecules Alkaloid Dioxoaporphine Isoquinoline Radical cyclisation Synthesis |
| title | Total Syntheses of Telisatin A, Telisatin B and Lettowianthine |
| title_full | Total Syntheses of Telisatin A, Telisatin B and Lettowianthine |
| title_fullStr | Total Syntheses of Telisatin A, Telisatin B and Lettowianthine |
| title_full_unstemmed | Total Syntheses of Telisatin A, Telisatin B and Lettowianthine |
| title_short | Total Syntheses of Telisatin A, Telisatin B and Lettowianthine |
| title_sort | total syntheses of telisatin a telisatin b and lettowianthine |
| topic | Alkaloid Dioxoaporphine Isoquinoline Radical cyclisation Synthesis |
| url | http://www.mdpi.com/1420-3049/14/3/917/ |