Anti-Obesity Effects of the Larval Powder of Steamed and Lyophilized Mature Silkworms in a Newly Designed Adult Mouse Model
Recently, “mature” silkworms (MS) of <i>Bombix mori</i> have been considered a potential nutraceutical, with a number of health benefits reported for steamed and lyophilized MS powder (SMSP). However, no obesity-related effects have been reported for SMSP. In the present study, anti-obes...
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MDPI AG
2023-09-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/12/19/3613 |
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| author | Min Woo Kim Yu-Jin Ham Hyun-Bok Kim Ji young Lee Jung-Dae Lim Hyun-Tai Lee |
| author_facet | Min Woo Kim Yu-Jin Ham Hyun-Bok Kim Ji young Lee Jung-Dae Lim Hyun-Tai Lee |
| author_sort | Min Woo Kim |
| collection | DOAJ |
| description | Recently, “mature” silkworms (MS) of <i>Bombix mori</i> have been considered a potential nutraceutical, with a number of health benefits reported for steamed and lyophilized MS powder (SMSP). However, no obesity-related effects have been reported for SMSP. In the present study, anti-obesity effects of SMSP were investigated in adult mice in vivo, aged 12 weeks at the onset of SMSP treatment, fed a normal diet (ND) and a high-fat diet (HFD), respectively, for 12 weeks. SMSP significantly suppressed body weight gain, intra-abdominal adipose tissue, and food efficiency in both ND-fed and HFD-fed adult mice. In addition, SMSP significantly decreased food intake and liver weight in HFD-fed mice, indicating that SMSP suppressed appetite and simultaneously reduced the conversion of feed into body weight in HFD-fed mice. SMSP also significantly lowered the serum levels of glucose, triglyceride, total cholesterol, low-density lipoprotein cholesterol, asparagine transaminase, alanine transaminase, and alkaline phosphatase. However, SMSP had no significant effect on the weights of the kidney, spleen, or thymus or the serum levels of blood urea nitrogen and creatinine. Taken together, the above results suggest that SMSP has potent anti-obesity effects and is safe for long-term use as a potential therapeutic and/or nutraceutical in both obese patients and non-obese individuals. |
| first_indexed | 2024-03-10T21:44:33Z |
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| id | doaj.art-4682b03ac8e64ad89e92acd24948a11f |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T21:44:33Z |
| publishDate | 2023-09-01 |
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| record_format | Article |
| series | Foods |
| spelling | doaj.art-4682b03ac8e64ad89e92acd24948a11f2023-11-19T14:23:19ZengMDPI AGFoods2304-81582023-09-011219361310.3390/foods12193613Anti-Obesity Effects of the Larval Powder of Steamed and Lyophilized Mature Silkworms in a Newly Designed Adult Mouse ModelMin Woo Kim0Yu-Jin Ham1Hyun-Bok Kim2Ji young Lee3Jung-Dae Lim4Hyun-Tai Lee5Biopharmaceutical Engineering Major, Division of Applied Bioengineering, College of Engineering, Dong-eui University, Busan 47340, Republic of KoreaBiopharmaceutical Engineering Major, Division of Applied Bioengineering, College of Engineering, Dong-eui University, Busan 47340, Republic of KoreaNational Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, Republic of KoreaDepartment of Ophthalmology and Visual Science, Daejeon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of KoreaDepartment of Herbal Medicine Resource, Kangwon National University, Samcheok 25949, Republic of KoreaBiopharmaceutical Engineering Major, Division of Applied Bioengineering, College of Engineering, Dong-eui University, Busan 47340, Republic of KoreaRecently, “mature” silkworms (MS) of <i>Bombix mori</i> have been considered a potential nutraceutical, with a number of health benefits reported for steamed and lyophilized MS powder (SMSP). However, no obesity-related effects have been reported for SMSP. In the present study, anti-obesity effects of SMSP were investigated in adult mice in vivo, aged 12 weeks at the onset of SMSP treatment, fed a normal diet (ND) and a high-fat diet (HFD), respectively, for 12 weeks. SMSP significantly suppressed body weight gain, intra-abdominal adipose tissue, and food efficiency in both ND-fed and HFD-fed adult mice. In addition, SMSP significantly decreased food intake and liver weight in HFD-fed mice, indicating that SMSP suppressed appetite and simultaneously reduced the conversion of feed into body weight in HFD-fed mice. SMSP also significantly lowered the serum levels of glucose, triglyceride, total cholesterol, low-density lipoprotein cholesterol, asparagine transaminase, alanine transaminase, and alkaline phosphatase. However, SMSP had no significant effect on the weights of the kidney, spleen, or thymus or the serum levels of blood urea nitrogen and creatinine. Taken together, the above results suggest that SMSP has potent anti-obesity effects and is safe for long-term use as a potential therapeutic and/or nutraceutical in both obese patients and non-obese individuals.https://www.mdpi.com/2304-8158/12/19/3613adipose tissueappetitebody weight<i>Bombyx mori</i>high-fat dietfood intake |
| spellingShingle | Min Woo Kim Yu-Jin Ham Hyun-Bok Kim Ji young Lee Jung-Dae Lim Hyun-Tai Lee Anti-Obesity Effects of the Larval Powder of Steamed and Lyophilized Mature Silkworms in a Newly Designed Adult Mouse Model Foods adipose tissue appetite body weight <i>Bombyx mori</i> high-fat diet food intake |
| title | Anti-Obesity Effects of the Larval Powder of Steamed and Lyophilized Mature Silkworms in a Newly Designed Adult Mouse Model |
| title_full | Anti-Obesity Effects of the Larval Powder of Steamed and Lyophilized Mature Silkworms in a Newly Designed Adult Mouse Model |
| title_fullStr | Anti-Obesity Effects of the Larval Powder of Steamed and Lyophilized Mature Silkworms in a Newly Designed Adult Mouse Model |
| title_full_unstemmed | Anti-Obesity Effects of the Larval Powder of Steamed and Lyophilized Mature Silkworms in a Newly Designed Adult Mouse Model |
| title_short | Anti-Obesity Effects of the Larval Powder of Steamed and Lyophilized Mature Silkworms in a Newly Designed Adult Mouse Model |
| title_sort | anti obesity effects of the larval powder of steamed and lyophilized mature silkworms in a newly designed adult mouse model |
| topic | adipose tissue appetite body weight <i>Bombyx mori</i> high-fat diet food intake |
| url | https://www.mdpi.com/2304-8158/12/19/3613 |
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