Effect of <em>Moringa oleifera</em> on haematological parameters: a systematic review
Background: Moringa (Moringa oleifera) is a plant found in many regions. Its extracts, especially of leaves, are a rich source of fibre, proteins and micronutrients including iron, thus potentially be used for haematological-applications including iron-deficiency-anaemia, affecting approximately one...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
College of Community Physicians of Sri Lanka
2022-09-01
|
| Series: | Journal of the College of Community Physicians |
| Subjects: | |
| Online Access: | https://account.jccpsl.sljol.info/index.php/sljo-j-jccpsl/article/view/8471 |
| _version_ | 1797360786660655104 |
|---|---|
| author | Chiara Perera D. I. Galappatti A. M. Thrimavithana Iresha Jayawickrama Buddhika Mahesh Mahendra Arnold Ruwan Ferdinando Wasantha Gunathunga |
| author_facet | Chiara Perera D. I. Galappatti A. M. Thrimavithana Iresha Jayawickrama Buddhika Mahesh Mahendra Arnold Ruwan Ferdinando Wasantha Gunathunga |
| author_sort | Chiara Perera |
| collection | DOAJ |
| description | Background: Moringa (Moringa oleifera) is a plant found in many regions. Its extracts, especially of leaves, are a rich source of fibre, proteins and micronutrients including iron, thus potentially be used for haematological-applications including iron-deficiency-anaemia, affecting approximately one-third of the global population.
Aims: To systematically-review the effect of moringa on haematological-parameters.
Methods: Preferred-Reporting-Items-for-Systematic-Reviews (PRISMA) guidelines were followed. PubMed, Cochrane-library, Agricola, CINAHL and EMBASE databases were searched. Selection of articles were done in three rounds by two independent reviewers intervened by a third, resolving conflicts. Human-studies on Moringa with relevant outcomes were included. Risk-of-bias assessment was done with Grading-of-Recommendations-Assessment-Development-and-Evaluation (GRADE) criteria. Heterogeneity was assessed and results were narratively-synthesized without meta-analysis. Registration from International-Prospective-Register-of-Systematic-Reviews (ID: CRD42020181432) was obtained.
Results: Following de-duplication there were 213 articles. Six studies on Moringa-leaf extracts, covering nine outcomes were included. Four studies included children below 2 years and two included reproductive and post-menopausal women. Among children under 2 years, mean improvement in heamoglobin-level ranged between 0.31-2.6g/dl with a reduction of the prevalence of anaemia by 53% (95%CI:35.1-72.0;p<0.001). Haemoglobin-level among anaemic women in reproductive-ages showed an improvement with a mean difference (MD) of 0.794(SD 0.81)(p <0.05) in the interventional group, and in the control group, the MD was 0.644(SD 0.83). Post-menopausal-women showed a significant improvement of 17.5% in haemoglobin compared to baseline values (p ≥0.01). Two studies showed improvements in ferritin-levels with a MD of 29.378ng/mL (SD 42.48) (p-0.012) among anaemic women and 31.9 (SD 23.8) MD among children under 2 years. One study showed an improvement [MD(SD)] in erythrocyte count 0.482(2.26), hematocrit 0.947(4.56), MCV 0.635(11.22), MCH 1.312(4.94), MCHC 2.459(2.86), and RDW 1.400(2.07) compared to the control group.
Conclusions and Recommendations: Moringa-leaf extracts as a natural supplement, is seemingly useful for improving haematological parameters, especially in improving the haemoglobin level among children and female adults. |
| first_indexed | 2024-03-08T15:44:41Z |
| format | Article |
| id | doaj.art-46833d73885146f9af4f929bad9f3f8c |
| institution | Directory Open Access Journal |
| issn | 1391-3174 2579-1451 |
| language | English |
| last_indexed | 2024-03-08T15:44:41Z |
| publishDate | 2022-09-01 |
| publisher | College of Community Physicians of Sri Lanka |
| record_format | Article |
| series | Journal of the College of Community Physicians |
| spelling | doaj.art-46833d73885146f9af4f929bad9f3f8c2024-01-09T12:13:54ZengCollege of Community Physicians of Sri LankaJournal of the College of Community Physicians1391-31742579-14512022-09-0128210.4038/jccpsl.v28i2.8471Effect of <em>Moringa oleifera</em> on haematological parameters: a systematic reviewChiara Perera0D. I. Galappatti1A. M. Thrimavithana2Iresha Jayawickrama3Buddhika Mahesh4Mahendra Arnold5Ruwan Ferdinando6Wasantha Gunathunga7Ministry of HealthMinistry of HealthMinistry of HealthMinistry of HealthMinistry of HealthMinistry of HealthMinistry of HealthUniversity of ColomboBackground: Moringa (Moringa oleifera) is a plant found in many regions. Its extracts, especially of leaves, are a rich source of fibre, proteins and micronutrients including iron, thus potentially be used for haematological-applications including iron-deficiency-anaemia, affecting approximately one-third of the global population. Aims: To systematically-review the effect of moringa on haematological-parameters. Methods: Preferred-Reporting-Items-for-Systematic-Reviews (PRISMA) guidelines were followed. PubMed, Cochrane-library, Agricola, CINAHL and EMBASE databases were searched. Selection of articles were done in three rounds by two independent reviewers intervened by a third, resolving conflicts. Human-studies on Moringa with relevant outcomes were included. Risk-of-bias assessment was done with Grading-of-Recommendations-Assessment-Development-and-Evaluation (GRADE) criteria. Heterogeneity was assessed and results were narratively-synthesized without meta-analysis. Registration from International-Prospective-Register-of-Systematic-Reviews (ID: CRD42020181432) was obtained. Results: Following de-duplication there were 213 articles. Six studies on Moringa-leaf extracts, covering nine outcomes were included. Four studies included children below 2 years and two included reproductive and post-menopausal women. Among children under 2 years, mean improvement in heamoglobin-level ranged between 0.31-2.6g/dl with a reduction of the prevalence of anaemia by 53% (95%CI:35.1-72.0;p<0.001). Haemoglobin-level among anaemic women in reproductive-ages showed an improvement with a mean difference (MD) of 0.794(SD 0.81)(p <0.05) in the interventional group, and in the control group, the MD was 0.644(SD 0.83). Post-menopausal-women showed a significant improvement of 17.5% in haemoglobin compared to baseline values (p ≥0.01). Two studies showed improvements in ferritin-levels with a MD of 29.378ng/mL (SD 42.48) (p-0.012) among anaemic women and 31.9 (SD 23.8) MD among children under 2 years. One study showed an improvement [MD(SD)] in erythrocyte count 0.482(2.26), hematocrit 0.947(4.56), MCV 0.635(11.22), MCH 1.312(4.94), MCHC 2.459(2.86), and RDW 1.400(2.07) compared to the control group. Conclusions and Recommendations: Moringa-leaf extracts as a natural supplement, is seemingly useful for improving haematological parameters, especially in improving the haemoglobin level among children and female adults.https://account.jccpsl.sljol.info/index.php/sljo-j-jccpsl/article/view/8471MoringaMoringa oleiferaanaemiahaemoglobinhematological parameters |
| spellingShingle | Chiara Perera D. I. Galappatti A. M. Thrimavithana Iresha Jayawickrama Buddhika Mahesh Mahendra Arnold Ruwan Ferdinando Wasantha Gunathunga Effect of <em>Moringa oleifera</em> on haematological parameters: a systematic review Journal of the College of Community Physicians Moringa Moringa oleifera anaemia haemoglobin hematological parameters |
| title | Effect of <em>Moringa oleifera</em> on haematological parameters: a systematic review |
| title_full | Effect of <em>Moringa oleifera</em> on haematological parameters: a systematic review |
| title_fullStr | Effect of <em>Moringa oleifera</em> on haematological parameters: a systematic review |
| title_full_unstemmed | Effect of <em>Moringa oleifera</em> on haematological parameters: a systematic review |
| title_short | Effect of <em>Moringa oleifera</em> on haematological parameters: a systematic review |
| title_sort | effect of em moringa oleifera em on haematological parameters a systematic review |
| topic | Moringa Moringa oleifera anaemia haemoglobin hematological parameters |
| url | https://account.jccpsl.sljol.info/index.php/sljo-j-jccpsl/article/view/8471 |
| work_keys_str_mv | AT chiaraperera effectofemmoringaoleiferaemonhaematologicalparametersasystematicreview AT digalappatti effectofemmoringaoleiferaemonhaematologicalparametersasystematicreview AT amthrimavithana effectofemmoringaoleiferaemonhaematologicalparametersasystematicreview AT ireshajayawickrama effectofemmoringaoleiferaemonhaematologicalparametersasystematicreview AT buddhikamahesh effectofemmoringaoleiferaemonhaematologicalparametersasystematicreview AT mahendraarnold effectofemmoringaoleiferaemonhaematologicalparametersasystematicreview AT ruwanferdinando effectofemmoringaoleiferaemonhaematologicalparametersasystematicreview AT wasanthagunathunga effectofemmoringaoleiferaemonhaematologicalparametersasystematicreview |