Functionalized Nanoparticles Activated by Photodynamic Therapy as an Antimicrobial Strategy in Endodontics: A Scoping Review
The eradication of endodontic pathogens continues to be the focus of the search for new root canal system (RCS) disinfection strategies. This scoping review provides a comprehensive synthesis of antimicrobial photodynamic therapy (aPDT) using nanoparticles (NPs) as an alternative to optimize RCS dis...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/9/1064 |
| _version_ | 1797520451736436736 |
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| author | Pablo Betancourt Nadia Brocal Eulàlia Sans-Serramitjana Carlos Zaror |
| author_facet | Pablo Betancourt Nadia Brocal Eulàlia Sans-Serramitjana Carlos Zaror |
| author_sort | Pablo Betancourt |
| collection | DOAJ |
| description | The eradication of endodontic pathogens continues to be the focus of the search for new root canal system (RCS) disinfection strategies. This scoping review provides a comprehensive synthesis of antimicrobial photodynamic therapy (aPDT) using nanoparticles (NPs) as an alternative to optimize RCS disinfection. A systematic search up to March 2021 was carried out using the MEDLINE, EMBASE, Scopus, Lilacs, Central Cochrane Library, and BBO databases. We included studies focused on evaluating the activation of NPs by aPDT in inoculated root canals of human or animal teeth or bacterial cultures in the laboratory. The selection process and data extraction were carried out by two researchers independently. A qualitative synthesis of the results was performed. A total of seventeen studies were included, of which twelve showed a substantial antibacterial efficacy, two assessed the substantivity of the disinfection effect, and three showed low cytotoxicity. No adverse effects were reported. The use of functionalized NPs with photosensitizer molecules in aPDT has been shown to be effective in reducing the bacteria count, making it a promising alternative in endodontic disinfection. Further studies are needed to assess the development of this therapy in in vivo conditions, with detailed information about the laser parameters used to allow the development of safe and standardized protocols. |
| first_indexed | 2024-03-10T07:56:57Z |
| format | Article |
| id | doaj.art-46834465f20d4afe88d0f5da52767462 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T07:56:57Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-46834465f20d4afe88d0f5da527674622023-11-22T11:45:41ZengMDPI AGAntibiotics2079-63822021-09-01109106410.3390/antibiotics10091064Functionalized Nanoparticles Activated by Photodynamic Therapy as an Antimicrobial Strategy in Endodontics: A Scoping ReviewPablo Betancourt0Nadia Brocal1Eulàlia Sans-Serramitjana2Carlos Zaror3Center for Research in Dental Sciences (CICO), Endodontic Laboratory, Faculty of Dentistry, Universidad de La Frontera, Temuco 4780000, ChileCenter for Research in Dental Sciences (CICO), Endodontic Laboratory, Faculty of Dentistry, Universidad de La Frontera, Temuco 4780000, ChileScientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera, Temuco 4780000, ChileDepartment of Pediatric Dentistry and Orthodontics, Faculty of Dentistry, Universidad de La Frontera, Temuco 4780000, ChileThe eradication of endodontic pathogens continues to be the focus of the search for new root canal system (RCS) disinfection strategies. This scoping review provides a comprehensive synthesis of antimicrobial photodynamic therapy (aPDT) using nanoparticles (NPs) as an alternative to optimize RCS disinfection. A systematic search up to March 2021 was carried out using the MEDLINE, EMBASE, Scopus, Lilacs, Central Cochrane Library, and BBO databases. We included studies focused on evaluating the activation of NPs by aPDT in inoculated root canals of human or animal teeth or bacterial cultures in the laboratory. The selection process and data extraction were carried out by two researchers independently. A qualitative synthesis of the results was performed. A total of seventeen studies were included, of which twelve showed a substantial antibacterial efficacy, two assessed the substantivity of the disinfection effect, and three showed low cytotoxicity. No adverse effects were reported. The use of functionalized NPs with photosensitizer molecules in aPDT has been shown to be effective in reducing the bacteria count, making it a promising alternative in endodontic disinfection. Further studies are needed to assess the development of this therapy in in vivo conditions, with detailed information about the laser parameters used to allow the development of safe and standardized protocols.https://www.mdpi.com/2079-6382/10/9/1064nanoparticlephotosensitizerantimicrobial photodynamic therapyroot canal infectionendodontics |
| spellingShingle | Pablo Betancourt Nadia Brocal Eulàlia Sans-Serramitjana Carlos Zaror Functionalized Nanoparticles Activated by Photodynamic Therapy as an Antimicrobial Strategy in Endodontics: A Scoping Review Antibiotics nanoparticle photosensitizer antimicrobial photodynamic therapy root canal infection endodontics |
| title | Functionalized Nanoparticles Activated by Photodynamic Therapy as an Antimicrobial Strategy in Endodontics: A Scoping Review |
| title_full | Functionalized Nanoparticles Activated by Photodynamic Therapy as an Antimicrobial Strategy in Endodontics: A Scoping Review |
| title_fullStr | Functionalized Nanoparticles Activated by Photodynamic Therapy as an Antimicrobial Strategy in Endodontics: A Scoping Review |
| title_full_unstemmed | Functionalized Nanoparticles Activated by Photodynamic Therapy as an Antimicrobial Strategy in Endodontics: A Scoping Review |
| title_short | Functionalized Nanoparticles Activated by Photodynamic Therapy as an Antimicrobial Strategy in Endodontics: A Scoping Review |
| title_sort | functionalized nanoparticles activated by photodynamic therapy as an antimicrobial strategy in endodontics a scoping review |
| topic | nanoparticle photosensitizer antimicrobial photodynamic therapy root canal infection endodontics |
| url | https://www.mdpi.com/2079-6382/10/9/1064 |
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