The role of atria in ventricular fibrillation after continuous-flow left ventricular assist device implantation in ovine model
ObjectivesThis study attempted to explore the hemodynamics and potential mechanisms driving pulmonary circulation in status of ventricular fibrillation (VF) following continuous-flow left ventricular assist device (CF-LVAD) implantation.MethodsAn ovine CF-LVAD model was built in small-tailed Han she...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1000352/full |
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| author | Xin-Yi Yu Jian-Wei Shi Yan-Sheng Rong Yuan-Lu Chen Tian-Wen Liu Yi-Rui Zang Ze-An Fu Ze-An Fu Jie-Min Zhang Zhi-Fu Han Zhi-Gang Liu Zhi-Gang Liu |
| author_facet | Xin-Yi Yu Jian-Wei Shi Yan-Sheng Rong Yuan-Lu Chen Tian-Wen Liu Yi-Rui Zang Ze-An Fu Ze-An Fu Jie-Min Zhang Zhi-Fu Han Zhi-Gang Liu Zhi-Gang Liu |
| author_sort | Xin-Yi Yu |
| collection | DOAJ |
| description | ObjectivesThis study attempted to explore the hemodynamics and potential mechanisms driving pulmonary circulation in status of ventricular fibrillation (VF) following continuous-flow left ventricular assist device (CF-LVAD) implantation.MethodsAn ovine CF-LVAD model was built in small-tailed Han sheep, with the pump speed set as 2,400 rpm. VF was induced following ventricular tachycardia using a temporary pacemaker probe to stimulate the right and left ventricular free walls. The central venous pressure (CVP), pump flow (PF), pulmonary artery flow (PAF) and other major indicators were observed and recorded after VF.ResultsLow-flow systemic and pulmonary circulation could be sustained for 60 min under VF with sinus atrial rhythm after CF-LVAD implantation. The CVP gradually increased. The mean PF declined from 1.80 to 1.20 L/min, and the mean PAF decreased from 1.62 L/min to 0.87 L/min. Under VF with atrial fibrillation, the systemic and pulmonary circulation couldn’t be sustained. The CVP jumped from the 5 mmHg baseline to 12 mmHg, the mean PF rapidly decreased from 3.45 L/min to 0.79 L/min, and the PAF declined from 3.94 L/min to 0.77 L/min.ConclusionThe atrial rhythm and function might be essential for the circulation maintenance in patients with VF after CF-LVAD implantation. |
| first_indexed | 2024-04-11T00:08:36Z |
| format | Article |
| id | doaj.art-46847425b68745ecb5ad90d97853cd76 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-11T00:08:36Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-46847425b68745ecb5ad90d97853cd762023-01-09T08:24:21ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-01-01910.3389/fcvm.2022.10003521000352The role of atria in ventricular fibrillation after continuous-flow left ventricular assist device implantation in ovine modelXin-Yi Yu0Jian-Wei Shi1Yan-Sheng Rong2Yuan-Lu Chen3Tian-Wen Liu4Yi-Rui Zang5Ze-An Fu6Ze-An Fu7Jie-Min Zhang8Zhi-Fu Han9Zhi-Gang Liu10Zhi-Gang Liu11Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, ChinaDepartment of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, ChinaDepartment of Anesthesiology, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, ChinaDepartment of Cardiac Electrophysiology, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, ChinaLaboratory Animal Center, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, ChinaDepartment of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, ChinaDepartment of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, ChinaCardiovascular Clinical College of Tianjin Medical University, Tianjin, ChinaLaboratory Animal Center, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, ChinaROCOR Medical Technology Co., Ltd., Tianjin, ChinaDepartment of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, ChinaCardiovascular Clinical College of Tianjin Medical University, Tianjin, ChinaObjectivesThis study attempted to explore the hemodynamics and potential mechanisms driving pulmonary circulation in status of ventricular fibrillation (VF) following continuous-flow left ventricular assist device (CF-LVAD) implantation.MethodsAn ovine CF-LVAD model was built in small-tailed Han sheep, with the pump speed set as 2,400 rpm. VF was induced following ventricular tachycardia using a temporary pacemaker probe to stimulate the right and left ventricular free walls. The central venous pressure (CVP), pump flow (PF), pulmonary artery flow (PAF) and other major indicators were observed and recorded after VF.ResultsLow-flow systemic and pulmonary circulation could be sustained for 60 min under VF with sinus atrial rhythm after CF-LVAD implantation. The CVP gradually increased. The mean PF declined from 1.80 to 1.20 L/min, and the mean PAF decreased from 1.62 L/min to 0.87 L/min. Under VF with atrial fibrillation, the systemic and pulmonary circulation couldn’t be sustained. The CVP jumped from the 5 mmHg baseline to 12 mmHg, the mean PF rapidly decreased from 3.45 L/min to 0.79 L/min, and the PAF declined from 3.94 L/min to 0.77 L/min.ConclusionThe atrial rhythm and function might be essential for the circulation maintenance in patients with VF after CF-LVAD implantation.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1000352/fullleft ventricular assist device (LVAD)ventricular fibrillation (VF)atriaarrhythmiaatrial function |
| spellingShingle | Xin-Yi Yu Jian-Wei Shi Yan-Sheng Rong Yuan-Lu Chen Tian-Wen Liu Yi-Rui Zang Ze-An Fu Ze-An Fu Jie-Min Zhang Zhi-Fu Han Zhi-Gang Liu Zhi-Gang Liu The role of atria in ventricular fibrillation after continuous-flow left ventricular assist device implantation in ovine model Frontiers in Cardiovascular Medicine left ventricular assist device (LVAD) ventricular fibrillation (VF) atria arrhythmia atrial function |
| title | The role of atria in ventricular fibrillation after continuous-flow left ventricular assist device implantation in ovine model |
| title_full | The role of atria in ventricular fibrillation after continuous-flow left ventricular assist device implantation in ovine model |
| title_fullStr | The role of atria in ventricular fibrillation after continuous-flow left ventricular assist device implantation in ovine model |
| title_full_unstemmed | The role of atria in ventricular fibrillation after continuous-flow left ventricular assist device implantation in ovine model |
| title_short | The role of atria in ventricular fibrillation after continuous-flow left ventricular assist device implantation in ovine model |
| title_sort | role of atria in ventricular fibrillation after continuous flow left ventricular assist device implantation in ovine model |
| topic | left ventricular assist device (LVAD) ventricular fibrillation (VF) atria arrhythmia atrial function |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1000352/full |
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