Olfactory Evaluation in Alzheimer’s Disease Model Mice
Olfactory dysfunction is considered a pre-cognitive biomarker of Alzheimer’s disease (AD). Because the olfactory system is highly conserved across species, mouse models corresponding to various AD etiologies have been bred and used in numerous studies on olfactory disorders. The olfactory behavior t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/5/607 |
| _version_ | 1797501163747147776 |
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| author | Jingjing Zhang Zixuan Zhao Siqi Sun Jing Li Yu Wang Jingyin Dong Su Yang Yiyi Lou Jing Yang Weiyun Li Shanshan Li |
| author_facet | Jingjing Zhang Zixuan Zhao Siqi Sun Jing Li Yu Wang Jingyin Dong Su Yang Yiyi Lou Jing Yang Weiyun Li Shanshan Li |
| author_sort | Jingjing Zhang |
| collection | DOAJ |
| description | Olfactory dysfunction is considered a pre-cognitive biomarker of Alzheimer’s disease (AD). Because the olfactory system is highly conserved across species, mouse models corresponding to various AD etiologies have been bred and used in numerous studies on olfactory disorders. The olfactory behavior test is a method required for early olfactory dysfunction detection in AD model mice. Here, we review the olfactory evaluation of AD model mice, focusing on traditional olfactory detection methods, olfactory behavior involving the olfactory cortex, and the results of olfactory behavior in AD model mice, aiming to provide some inspiration for further development of olfactory detection methods in AD model mice. |
| first_indexed | 2024-03-10T03:14:25Z |
| format | Article |
| id | doaj.art-46853ca01220441eaaba1ea7ec32856c |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T03:14:25Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-46853ca01220441eaaba1ea7ec32856c2023-11-23T10:17:49ZengMDPI AGBrain Sciences2076-34252022-05-0112560710.3390/brainsci12050607Olfactory Evaluation in Alzheimer’s Disease Model MiceJingjing Zhang0Zixuan Zhao1Siqi Sun2Jing Li3Yu Wang4Jingyin Dong5Su Yang6Yiyi Lou7Jing Yang8Weiyun Li9Shanshan Li10Department of Basic Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, ChinaDepartment of Basic Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, ChinaDepartment of Basic Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, ChinaInstitute of Neuroscience and Anatomy, School of Medicine, Zhejiang University, Hangzhou 310058, ChinaHangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310053, ChinaDepartment of Basic Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, ChinaSir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310020, ChinaSir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310020, ChinaDepartment of Basic Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, ChinaDepartment of Basic Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, ChinaDepartment of Basic Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, ChinaOlfactory dysfunction is considered a pre-cognitive biomarker of Alzheimer’s disease (AD). Because the olfactory system is highly conserved across species, mouse models corresponding to various AD etiologies have been bred and used in numerous studies on olfactory disorders. The olfactory behavior test is a method required for early olfactory dysfunction detection in AD model mice. Here, we review the olfactory evaluation of AD model mice, focusing on traditional olfactory detection methods, olfactory behavior involving the olfactory cortex, and the results of olfactory behavior in AD model mice, aiming to provide some inspiration for further development of olfactory detection methods in AD model mice.https://www.mdpi.com/2076-3425/12/5/607olfactory evaluationAlzheimer’s disease model miceolfactory behavior test |
| spellingShingle | Jingjing Zhang Zixuan Zhao Siqi Sun Jing Li Yu Wang Jingyin Dong Su Yang Yiyi Lou Jing Yang Weiyun Li Shanshan Li Olfactory Evaluation in Alzheimer’s Disease Model Mice Brain Sciences olfactory evaluation Alzheimer’s disease model mice olfactory behavior test |
| title | Olfactory Evaluation in Alzheimer’s Disease Model Mice |
| title_full | Olfactory Evaluation in Alzheimer’s Disease Model Mice |
| title_fullStr | Olfactory Evaluation in Alzheimer’s Disease Model Mice |
| title_full_unstemmed | Olfactory Evaluation in Alzheimer’s Disease Model Mice |
| title_short | Olfactory Evaluation in Alzheimer’s Disease Model Mice |
| title_sort | olfactory evaluation in alzheimer s disease model mice |
| topic | olfactory evaluation Alzheimer’s disease model mice olfactory behavior test |
| url | https://www.mdpi.com/2076-3425/12/5/607 |
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