Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data
Rhipicephalus microplus causes huge losses in cattle. Host genetic background greatly affects the immune efficiency in resistance or susceptibility to tick infestation, which is one of the many factors that play a role on that trait. We performed a systematic review of genome-wide association studie...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Journal of Applied Animal Research |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/09712119.2022.2096035 |
| _version_ | 1828399460606017536 |
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| author | Cassiane Gomes dos Santos Mariele Freitas Sousa João Inácio Gomes Vieira Luana Rafaela de Morais Aline Auxiliadora Silva Fernandes Thayssa de Oliveira Littiere Pamela Itajara Otto Marco Antônio Machado Marcos Vinicius Gualberto Barbosa Silva Cristina Moreira Bonafé Ana Fabrícia Braga Magalhães Lucas Lima Verardo |
| author_facet | Cassiane Gomes dos Santos Mariele Freitas Sousa João Inácio Gomes Vieira Luana Rafaela de Morais Aline Auxiliadora Silva Fernandes Thayssa de Oliveira Littiere Pamela Itajara Otto Marco Antônio Machado Marcos Vinicius Gualberto Barbosa Silva Cristina Moreira Bonafé Ana Fabrícia Braga Magalhães Lucas Lima Verardo |
| author_sort | Cassiane Gomes dos Santos |
| collection | DOAJ |
| description | Rhipicephalus microplus causes huge losses in cattle. Host genetic background greatly affects the immune efficiency in resistance or susceptibility to tick infestation, which is one of the many factors that play a role on that trait. We performed a systematic review of genome-wide association studies (GWAS) for tick resistance in cattle resulting in 1353 candidate genes for post-GWAS analyses. From those, genes showing possible structural variants from the bovine genome were classified by the Variant Effect Predictor from Ensembl. Ninety-two candidate genes showed potential structural variants in 5′ UTR and coding region and were used for functional annotation. Enriched biological processes (e.g. regulation of eosinophil chemotaxis, RIG-I signalling pathway and monocyte differentiation) and candidate genes (e.g. DAPK2, PUM1, ACIN1, INPP5D) linked with immune system function were identified and thus associated with tick resistance. Besides, gene-transcription factors (TFs) networks were obtained from TFs associated with immune system (FOXO3, PPARG, STAT3, NFKB1, GATA3 and ARNT) and the candidate genes associated with tick resistance in cattle highlighted (e.g. OR4L1, PNP, LRRIQ1, GIMAP8, MYO6, MEP1A and LRFN2). Thus, promising candidate genes with a possible functional role for tick resistance in cattle are presented for further in vitro and/or in vivo analyses. |
| first_indexed | 2024-12-10T09:17:44Z |
| format | Article |
| id | doaj.art-4685a5fd98554de098852c45270b7a92 |
| institution | Directory Open Access Journal |
| issn | 0971-2119 0974-1844 |
| language | English |
| last_indexed | 2024-12-10T09:17:44Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Applied Animal Research |
| spelling | doaj.art-4685a5fd98554de098852c45270b7a922022-12-22T01:54:47ZengTaylor & Francis GroupJournal of Applied Animal Research0971-21190974-18442022-12-0150146047010.1080/09712119.2022.2096035Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing dataCassiane Gomes dos Santos0Mariele Freitas Sousa1João Inácio Gomes Vieira2Luana Rafaela de Morais3Aline Auxiliadora Silva Fernandes4Thayssa de Oliveira Littiere5Pamela Itajara Otto6Marco Antônio Machado7Marcos Vinicius Gualberto Barbosa Silva8Cristina Moreira Bonafé9Ana Fabrícia Braga Magalhães10Lucas Lima Verardo11Department of Animal Science, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, BrazilDepartment of Animal Science, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, BrazilDepartment of Animal Science, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, BrazilDepartment of Animal Science, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, BrazilDepartment of Animal Science, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, BrazilDepartment of Animal Science, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, BrazilDepartment of Animal Science, Universidade Federal de Santa Maria, Santa Maria, BrazilEmbrapa Gado de Leite, Juiz de Fora, BrazilEmbrapa Gado de Leite, Juiz de Fora, BrazilDepartment of Animal Science, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, BrazilDepartment of Animal Science, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, BrazilDepartment of Animal Science, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, BrazilRhipicephalus microplus causes huge losses in cattle. Host genetic background greatly affects the immune efficiency in resistance or susceptibility to tick infestation, which is one of the many factors that play a role on that trait. We performed a systematic review of genome-wide association studies (GWAS) for tick resistance in cattle resulting in 1353 candidate genes for post-GWAS analyses. From those, genes showing possible structural variants from the bovine genome were classified by the Variant Effect Predictor from Ensembl. Ninety-two candidate genes showed potential structural variants in 5′ UTR and coding region and were used for functional annotation. Enriched biological processes (e.g. regulation of eosinophil chemotaxis, RIG-I signalling pathway and monocyte differentiation) and candidate genes (e.g. DAPK2, PUM1, ACIN1, INPP5D) linked with immune system function were identified and thus associated with tick resistance. Besides, gene-transcription factors (TFs) networks were obtained from TFs associated with immune system (FOXO3, PPARG, STAT3, NFKB1, GATA3 and ARNT) and the candidate genes associated with tick resistance in cattle highlighted (e.g. OR4L1, PNP, LRRIQ1, GIMAP8, MYO6, MEP1A and LRFN2). Thus, promising candidate genes with a possible functional role for tick resistance in cattle are presented for further in vitro and/or in vivo analyses.https://www.tandfonline.com/doi/10.1080/09712119.2022.2096035Ectoparasitegenomeimmune systemgene networksdairybeef |
| spellingShingle | Cassiane Gomes dos Santos Mariele Freitas Sousa João Inácio Gomes Vieira Luana Rafaela de Morais Aline Auxiliadora Silva Fernandes Thayssa de Oliveira Littiere Pamela Itajara Otto Marco Antônio Machado Marcos Vinicius Gualberto Barbosa Silva Cristina Moreira Bonafé Ana Fabrícia Braga Magalhães Lucas Lima Verardo Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data Journal of Applied Animal Research Ectoparasite genome immune system gene networks dairy beef |
| title | Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data |
| title_full | Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data |
| title_fullStr | Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data |
| title_full_unstemmed | Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data |
| title_short | Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data |
| title_sort | candidate genes for tick resistance in cattle a systematic review combining post gwas analyses with sequencing data |
| topic | Ectoparasite genome immune system gene networks dairy beef |
| url | https://www.tandfonline.com/doi/10.1080/09712119.2022.2096035 |
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