Acquired radioresistance in cancer associated fibroblasts is concomitant with enhanced antioxidant potential and DNA repair capacity

Acquired radioresistance in cancer associated fibroblasts is concomitant with enhanced antioxidant potential and DNA repair capacity

Abstract Background Cancer-associated fibroblasts (CAFs) are a major component of the cancer stroma, and their response to therapeutic treatments likely impacts the outcome. We tested the hypothesis that CAFs develop unique characteristics that enhance their resistance to ionizing radiation. Methods...

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Bibliographic Details
Main Authors: Jason D. Domogauer, Sonia M. de Toledo, Roger W. Howell, Edouard I. Azzam
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Cell Communication and Signaling
Subjects:
Cancer associated fibroblasts
Radiotherapy
Radioresistance
Oxidative metabolism
DNA repair
Intercellular communication
Online Access:https://doi.org/10.1186/s12964-021-00711-4

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