Decreased Cystatin C–Estimated Glomerular Filtration Rate Is Correlated with Prolonged Hospital Stay in Transient Tachypnea of Newborn Infants
Transient tachypnea of the newborn (TTN) is a benign disorder with a variable clinical course that often leads to hospitalization. The aim of this study was to assess and validate the relationship between the serum cystatin C level and symptom duration in infants with TTN. Methods: Forty newborns pr...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-06-01
|
| Series: | Pediatrics and Neonatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957215001412 |
| _version_ | 1828870437254201344 |
|---|---|
| author | Bo Bae Kim Sung-Hoon Chung Hoi-Soo Yoon Won-Ho Hahn Chong-Woo Bae Yong-Sung Choi |
| author_facet | Bo Bae Kim Sung-Hoon Chung Hoi-Soo Yoon Won-Ho Hahn Chong-Woo Bae Yong-Sung Choi |
| author_sort | Bo Bae Kim |
| collection | DOAJ |
| description | Transient tachypnea of the newborn (TTN) is a benign disorder with a variable clinical course that often leads to hospitalization. The aim of this study was to assess and validate the relationship between the serum cystatin C level and symptom duration in infants with TTN.
Methods: Forty newborns presenting with TTN and who had undergone serum cystatin C (Cys C) tests on the first day of admission to the Kyung Hee University Hospital (Seoul, Korea) from 2009 to 2013 were included. The serum Cys C level, creatinine (Cr) level, estimated glomerular filtration rate (eGFR), and tachypnea duration were correlated retrospectively.
Results: The median gestation period was 37.8 ± 3.8 weeks and the mean birth weight was 3.2 ± 0.4 kg. Tachypnea duration was 3.3 ± 2.0 days. Serum Cys C and Cr levels were 1.7 ± 0.2 mg/L and 0.8 ± 1.2 mg/dL, respectively. Tachypnea duration was significantly positively correlated with the serum levels of Cys C and significantly negatively correlated with Cys C-based eGFR (p = 0.016), but was not significantly correlated with the serum Cr level or Cr-based eGFR. When tachypnea duration was compared between infants with Cys C level <1.6 mg/L (n = 15; Group A) and infants with Cys C level ≥ 1.6 mg/L (n = 25; Group B), the symptom duration was significantly shorter in Group A infants (p = 0.011).
Conclusion: Tachypnea duration was shorter with higher Cys C-based eGFR in infants with TTN. |
| first_indexed | 2024-12-13T06:12:03Z |
| format | Article |
| id | doaj.art-46873078f4dc451d941168b28506125f |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-12-13T06:12:03Z |
| publishDate | 2016-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-46873078f4dc451d941168b28506125f2022-12-21T23:57:04ZengElsevierPediatrics and Neonatology1875-95722016-06-0157319520010.1016/j.pedneo.2015.08.006Decreased Cystatin C–Estimated Glomerular Filtration Rate Is Correlated with Prolonged Hospital Stay in Transient Tachypnea of Newborn InfantsBo Bae Kim0Sung-Hoon Chung1Hoi-Soo Yoon2Won-Ho Hahn3Chong-Woo Bae4Yong-Sung Choi5Department of Pediatrics, Kyung Hee University School of Medicine, Seoul, South KoreaDepartment of Pediatrics, Kyung Hee University School of Medicine, Seoul, South KoreaDepartment of Pediatrics, Kyung Hee University School of Medicine, Seoul, South KoreaDepartment of Pediatrics, School of Medicine, Seoul Hospital, Soon Chun Hyang University, Seoul, South KoreaDepartment of Pediatrics, Kyung Hee University School of Medicine, Seoul, South KoreaDepartment of Pediatrics, Kyung Hee University School of Medicine, Seoul, South KoreaTransient tachypnea of the newborn (TTN) is a benign disorder with a variable clinical course that often leads to hospitalization. The aim of this study was to assess and validate the relationship between the serum cystatin C level and symptom duration in infants with TTN. Methods: Forty newborns presenting with TTN and who had undergone serum cystatin C (Cys C) tests on the first day of admission to the Kyung Hee University Hospital (Seoul, Korea) from 2009 to 2013 were included. The serum Cys C level, creatinine (Cr) level, estimated glomerular filtration rate (eGFR), and tachypnea duration were correlated retrospectively. Results: The median gestation period was 37.8 ± 3.8 weeks and the mean birth weight was 3.2 ± 0.4 kg. Tachypnea duration was 3.3 ± 2.0 days. Serum Cys C and Cr levels were 1.7 ± 0.2 mg/L and 0.8 ± 1.2 mg/dL, respectively. Tachypnea duration was significantly positively correlated with the serum levels of Cys C and significantly negatively correlated with Cys C-based eGFR (p = 0.016), but was not significantly correlated with the serum Cr level or Cr-based eGFR. When tachypnea duration was compared between infants with Cys C level <1.6 mg/L (n = 15; Group A) and infants with Cys C level ≥ 1.6 mg/L (n = 25; Group B), the symptom duration was significantly shorter in Group A infants (p = 0.011). Conclusion: Tachypnea duration was shorter with higher Cys C-based eGFR in infants with TTN.http://www.sciencedirect.com/science/article/pii/S1875957215001412transient tachypnea of the newbornglomerular filtration ratecystatin C |
| spellingShingle | Bo Bae Kim Sung-Hoon Chung Hoi-Soo Yoon Won-Ho Hahn Chong-Woo Bae Yong-Sung Choi Decreased Cystatin C–Estimated Glomerular Filtration Rate Is Correlated with Prolonged Hospital Stay in Transient Tachypnea of Newborn Infants Pediatrics and Neonatology transient tachypnea of the newborn glomerular filtration rate cystatin C |
| title | Decreased Cystatin C–Estimated Glomerular Filtration Rate Is Correlated with Prolonged Hospital Stay in Transient Tachypnea of Newborn Infants |
| title_full | Decreased Cystatin C–Estimated Glomerular Filtration Rate Is Correlated with Prolonged Hospital Stay in Transient Tachypnea of Newborn Infants |
| title_fullStr | Decreased Cystatin C–Estimated Glomerular Filtration Rate Is Correlated with Prolonged Hospital Stay in Transient Tachypnea of Newborn Infants |
| title_full_unstemmed | Decreased Cystatin C–Estimated Glomerular Filtration Rate Is Correlated with Prolonged Hospital Stay in Transient Tachypnea of Newborn Infants |
| title_short | Decreased Cystatin C–Estimated Glomerular Filtration Rate Is Correlated with Prolonged Hospital Stay in Transient Tachypnea of Newborn Infants |
| title_sort | decreased cystatin c estimated glomerular filtration rate is correlated with prolonged hospital stay in transient tachypnea of newborn infants |
| topic | transient tachypnea of the newborn glomerular filtration rate cystatin C |
| url | http://www.sciencedirect.com/science/article/pii/S1875957215001412 |
| work_keys_str_mv | AT bobaekim decreasedcystatincestimatedglomerularfiltrationrateiscorrelatedwithprolongedhospitalstayintransienttachypneaofnewborninfants AT sunghoonchung decreasedcystatincestimatedglomerularfiltrationrateiscorrelatedwithprolongedhospitalstayintransienttachypneaofnewborninfants AT hoisooyoon decreasedcystatincestimatedglomerularfiltrationrateiscorrelatedwithprolongedhospitalstayintransienttachypneaofnewborninfants AT wonhohahn decreasedcystatincestimatedglomerularfiltrationrateiscorrelatedwithprolongedhospitalstayintransienttachypneaofnewborninfants AT chongwoobae decreasedcystatincestimatedglomerularfiltrationrateiscorrelatedwithprolongedhospitalstayintransienttachypneaofnewborninfants AT yongsungchoi decreasedcystatincestimatedglomerularfiltrationrateiscorrelatedwithprolongedhospitalstayintransienttachypneaofnewborninfants |