Patients with nipple-areola Paget's disease and underlying invasive breast carcinoma have very poor survival: a matched cohort study.
Paget's disease (PD) of the breast is a rare disease. The survival rate of PD was reported to depend on the characteristics of the underlying carcinoma. This study aimed to investigate the characteristics and survival rate of PD patients with underlying invasive breast carcinoma (IBC). Fifty-tw...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3631229?pdf=render |
| _version_ | 1819104518113067008 |
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| author | Hong Ling Xin Hu Xiao-Li Xu Zhe-Bin Liu Zhi-Min Shao |
| author_facet | Hong Ling Xin Hu Xiao-Li Xu Zhe-Bin Liu Zhi-Min Shao |
| author_sort | Hong Ling |
| collection | DOAJ |
| description | Paget's disease (PD) of the breast is a rare disease. The survival rate of PD was reported to depend on the characteristics of the underlying carcinoma. This study aimed to investigate the characteristics and survival rate of PD patients with underlying invasive breast carcinoma (IBC). Fifty-two patients were diagnosed with PD and an associated IBC from 2001 to 2005 in Fudan University Shanghai Cancer Center. Twenty-four (46.2%) had no clinical manifestation of PD and were diagnosed unexpectedly by a histologic examination. The 52 patients were all recruited in this study as the PD group. They tended to have greater chances of lymph node involvement (53.8% vs. 35.7%), lower hormone receptor expression (34.6% vs. 69.7%), higher human epidermal growth factor receptor 2 (HER2) expression (76.9% vs. 21.3%), and worse survival (5-year relapse-free survival (RFS) 52.2% vs. 86.7%, P<0.01; breast cancer-specific overall survival (OS) 62.1% vs. 91.8%, P<0.01) when compared with patients diagnosed with IBC. A matched study was then performed to investigate whether the poor survival of patients in the PD group was due to the unfavorable prognosis of the underlying IBC. One hundred and fifty-six (3∶1 ratio of controls to PD patients) patients diagnosed with IBC only were recruited into the matched group. The match was conducted according to four variables: dimension of IBC, lymph node status, hormone receptor status and HER2 status. The 5-year RFS (52.2% vs. 81.4%, P<0.01) and OS (62.1% vs. 85.9%, P<0.01) were both lower for patients in the PD group than those in the matched group. Patients with PD and underlying IBC had poor survival. Their survival was worse than that of patients with IBC of similar stage and characteristics. For patients with no clinical PD manifestation who were histologically diagnosed as PD, survival might be worse compared to patients with clinically diagnosed PD. |
| first_indexed | 2024-12-22T02:07:37Z |
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| id | doaj.art-46874df9bdc143d186847c2b077b5883 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T02:07:37Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-46874df9bdc143d186847c2b077b58832022-12-21T18:42:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0184e6145510.1371/journal.pone.0061455Patients with nipple-areola Paget's disease and underlying invasive breast carcinoma have very poor survival: a matched cohort study.Hong LingXin HuXiao-Li XuZhe-Bin LiuZhi-Min ShaoPaget's disease (PD) of the breast is a rare disease. The survival rate of PD was reported to depend on the characteristics of the underlying carcinoma. This study aimed to investigate the characteristics and survival rate of PD patients with underlying invasive breast carcinoma (IBC). Fifty-two patients were diagnosed with PD and an associated IBC from 2001 to 2005 in Fudan University Shanghai Cancer Center. Twenty-four (46.2%) had no clinical manifestation of PD and were diagnosed unexpectedly by a histologic examination. The 52 patients were all recruited in this study as the PD group. They tended to have greater chances of lymph node involvement (53.8% vs. 35.7%), lower hormone receptor expression (34.6% vs. 69.7%), higher human epidermal growth factor receptor 2 (HER2) expression (76.9% vs. 21.3%), and worse survival (5-year relapse-free survival (RFS) 52.2% vs. 86.7%, P<0.01; breast cancer-specific overall survival (OS) 62.1% vs. 91.8%, P<0.01) when compared with patients diagnosed with IBC. A matched study was then performed to investigate whether the poor survival of patients in the PD group was due to the unfavorable prognosis of the underlying IBC. One hundred and fifty-six (3∶1 ratio of controls to PD patients) patients diagnosed with IBC only were recruited into the matched group. The match was conducted according to four variables: dimension of IBC, lymph node status, hormone receptor status and HER2 status. The 5-year RFS (52.2% vs. 81.4%, P<0.01) and OS (62.1% vs. 85.9%, P<0.01) were both lower for patients in the PD group than those in the matched group. Patients with PD and underlying IBC had poor survival. Their survival was worse than that of patients with IBC of similar stage and characteristics. For patients with no clinical PD manifestation who were histologically diagnosed as PD, survival might be worse compared to patients with clinically diagnosed PD.http://europepmc.org/articles/PMC3631229?pdf=render |
| spellingShingle | Hong Ling Xin Hu Xiao-Li Xu Zhe-Bin Liu Zhi-Min Shao Patients with nipple-areola Paget's disease and underlying invasive breast carcinoma have very poor survival: a matched cohort study. PLoS ONE |
| title | Patients with nipple-areola Paget's disease and underlying invasive breast carcinoma have very poor survival: a matched cohort study. |
| title_full | Patients with nipple-areola Paget's disease and underlying invasive breast carcinoma have very poor survival: a matched cohort study. |
| title_fullStr | Patients with nipple-areola Paget's disease and underlying invasive breast carcinoma have very poor survival: a matched cohort study. |
| title_full_unstemmed | Patients with nipple-areola Paget's disease and underlying invasive breast carcinoma have very poor survival: a matched cohort study. |
| title_short | Patients with nipple-areola Paget's disease and underlying invasive breast carcinoma have very poor survival: a matched cohort study. |
| title_sort | patients with nipple areola paget s disease and underlying invasive breast carcinoma have very poor survival a matched cohort study |
| url | http://europepmc.org/articles/PMC3631229?pdf=render |
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