Blocking the interaction between interleukin-17A and endoplasmic reticulum stress in macrophage attenuates retinal neovascularization in oxygen-induced retinopathy

Blocking the interaction between interleukin-17A and endoplasmic reticulum stress in macrophage attenuates retinal neovascularization in oxygen-induced retinopathy

Abstract Background Neovascularization is a leading cause of visual loss typically associated with diabetic retinopathy (DR) and retinopathy of prematurity (ROP). Interleukin-17A (IL-17A) and endoplasmic reticulum (ER) stress both have been demonstrated to play a proangiogenic role in ischemic retin...

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Bibliographic Details
Main Authors: Ya’nuo Wang, Shuang Gao, Sha Gao, Na Li, Bing Xie, Xi Shen
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Cell & Bioscience
Subjects:
Endoplasmic reticulum stress
Interleukin-17A
TXNIP/NLRP3 pathway
Retinal neovascularization
Oxygen-induced retinopathy
Ischemic retinopathy
Online Access:https://doi.org/10.1186/s13578-021-00593-6

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