Reproductive toxicity of combined effects of endocrine disruptors on human reproduction
Confluence of environmental, genetic, and lifestyle variables is responsible for deterioration of human fecundity. Endocrine disruptors or endocrine disrupting chemicals (EDCs) may be found in a variety of foods, water, air, beverages, and tobacco smoke. It has been demonstrated in experimental inve...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1162015/full |
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| author | Sulagna Dutta Pallav Sengupta Sovan Bagchi Bhupender S. Chhikara Aleš Pavlík Petr Sláma Shubhadeep Roychoudhury |
| author_facet | Sulagna Dutta Pallav Sengupta Sovan Bagchi Bhupender S. Chhikara Aleš Pavlík Petr Sláma Shubhadeep Roychoudhury |
| author_sort | Sulagna Dutta |
| collection | DOAJ |
| description | Confluence of environmental, genetic, and lifestyle variables is responsible for deterioration of human fecundity. Endocrine disruptors or endocrine disrupting chemicals (EDCs) may be found in a variety of foods, water, air, beverages, and tobacco smoke. It has been demonstrated in experimental investigations that a wide range of endocrine disrupting chemicals have negative effects on human reproductive function. However, evidence on the reproductive consequences of human exposure to endocrine disrupting chemicals is sparse and/or conflicting in the scientific literature. The combined toxicological assessment is a practical method for assessing the hazards of cocktails of chemicals, co-existing in the environment. The current review provides a comprehensive overview of studies emphasizing the combined toxicity of endocrine disrupting chemicals on human reproduction. Endocrine disrupting chemicals interact with each other to disrupt the different endocrine axes, resulting in severe gonadal dysfunctions. Transgenerational epigenetic effects have also been induced in germ cells, mostly through DNA methylation and epimutations. Similarly, after acute or chronic exposure to endocrine disrupting chemicals combinations, increased oxidative stress (OS), elevated antioxidant enzymatic activity, disrupted reproductive cycle, and reduced steroidogenesis are often reported consequences. The article also discusses the concentration addition (CA) and independent action (IA) prediction models, which reveal the importance of various synergistic actions of endocrine disrupting chemicals mixtures. More crucially, this evidence-based study addresses the research limitations and information gaps, as well as particularly presents the future research views on combined endocrine disrupting chemicals toxicity on human reproduction. |
| first_indexed | 2024-04-09T13:10:05Z |
| format | Article |
| id | doaj.art-4688a92d6a2946a7a39874aa5b2100c5 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-09T13:10:05Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-4688a92d6a2946a7a39874aa5b2100c52023-05-12T08:21:47ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-05-011110.3389/fcell.2023.11620151162015Reproductive toxicity of combined effects of endocrine disruptors on human reproductionSulagna Dutta0Pallav Sengupta1Sovan Bagchi2Bhupender S. Chhikara3Aleš Pavlík4Petr Sláma5Shubhadeep Roychoudhury6School of Medical Sciences, Bharath Institute of Higher Education and Research (BIHER), Chennai, Tamil Nadu, IndiaDepartment of Biomedical Sciences, College of Medicine, Gulf Medical University, Ajman, United Arab EmiratesDepartment of Biomedical Sciences, College of Medicine, Gulf Medical University, Ajman, United Arab EmiratesMolecular Medicinal and Material NanoChemistry Laboratory, Department of Chemistry, Aditi Mahavidyalaya, University of Delhi, Delhi, IndiaLaboratory of Animal Physiology, Department of Animal Morphology, Physiology and Genetics, Faculty of AgriSciences, Mendel University in Brno, Brno, CzechiaLaboratory of Animal Immunology and Biotechnology, Department of Animal Morphology, Physiology and Genetics, Faculty of AgriSciences, Mendel University in Brno, Brno, CzechiaDepartment of Life Science and Bioinformatics, Assam University, Silchar, IndiaConfluence of environmental, genetic, and lifestyle variables is responsible for deterioration of human fecundity. Endocrine disruptors or endocrine disrupting chemicals (EDCs) may be found in a variety of foods, water, air, beverages, and tobacco smoke. It has been demonstrated in experimental investigations that a wide range of endocrine disrupting chemicals have negative effects on human reproductive function. However, evidence on the reproductive consequences of human exposure to endocrine disrupting chemicals is sparse and/or conflicting in the scientific literature. The combined toxicological assessment is a practical method for assessing the hazards of cocktails of chemicals, co-existing in the environment. The current review provides a comprehensive overview of studies emphasizing the combined toxicity of endocrine disrupting chemicals on human reproduction. Endocrine disrupting chemicals interact with each other to disrupt the different endocrine axes, resulting in severe gonadal dysfunctions. Transgenerational epigenetic effects have also been induced in germ cells, mostly through DNA methylation and epimutations. Similarly, after acute or chronic exposure to endocrine disrupting chemicals combinations, increased oxidative stress (OS), elevated antioxidant enzymatic activity, disrupted reproductive cycle, and reduced steroidogenesis are often reported consequences. The article also discusses the concentration addition (CA) and independent action (IA) prediction models, which reveal the importance of various synergistic actions of endocrine disrupting chemicals mixtures. More crucially, this evidence-based study addresses the research limitations and information gaps, as well as particularly presents the future research views on combined endocrine disrupting chemicals toxicity on human reproduction.https://www.frontiersin.org/articles/10.3389/fcell.2023.1162015/fullendocrine disrupting chemicalsmetalshuman fertilityinfertilityoxidative stressreductive stress |
| spellingShingle | Sulagna Dutta Pallav Sengupta Sovan Bagchi Bhupender S. Chhikara Aleš Pavlík Petr Sláma Shubhadeep Roychoudhury Reproductive toxicity of combined effects of endocrine disruptors on human reproduction Frontiers in Cell and Developmental Biology endocrine disrupting chemicals metals human fertility infertility oxidative stress reductive stress |
| title | Reproductive toxicity of combined effects of endocrine disruptors on human reproduction |
| title_full | Reproductive toxicity of combined effects of endocrine disruptors on human reproduction |
| title_fullStr | Reproductive toxicity of combined effects of endocrine disruptors on human reproduction |
| title_full_unstemmed | Reproductive toxicity of combined effects of endocrine disruptors on human reproduction |
| title_short | Reproductive toxicity of combined effects of endocrine disruptors on human reproduction |
| title_sort | reproductive toxicity of combined effects of endocrine disruptors on human reproduction |
| topic | endocrine disrupting chemicals metals human fertility infertility oxidative stress reductive stress |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1162015/full |
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