INFLUENCE OF CYTOMEGALOVIRUS PERSISTENCE UPON CLINICAL COURSE OF BRONCHIAL ASTHMA (BA) IN CHILDREN
Abstract. We have performed a study of 117 children (106 with BА, and 11, a comparison group). Upon examination of BA patients, they exhibited high rates of pneumotropic intracellular infections more frequent is found out, in comparison with healthy children, endocellular infection pathogens, in par...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/347 |
| _version_ | 1826534317252149248 |
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| author | Е. N. Suprun V. K. Kozlov O. I. Morozova M. V. Efimenko |
| author_facet | Е. N. Suprun V. K. Kozlov O. I. Morozova M. V. Efimenko |
| author_sort | Е. N. Suprun |
| collection | DOAJ |
| description | Abstract. We have performed a study of 117 children (106 with BА, and 11, a comparison group). Upon examination of BA patients, they exhibited high rates of pneumotropic intracellular infections more frequent is found out, in comparison with healthy children, endocellular infection pathogens, in particular, cytomegalovirus (CMV), as shown by more frequent detection of specific IgM, IgG, and detection of virus-specific DNA in sputum samples of the sick children suffering with BA. In the children with BА shedding CMV DNA with sputum, a more severe clinical course of the disease was shown, as evidenced by more frequent bronchial obstruction episodes, and more severe symptoms. Decreased levels of all lymphocyte subpopulations was revealed in the patients, but in CMV-positive children, this drop was more pronounced, and accompanied by increase in CD4+ and decrease in CD8+ subpopulations, higher levels of IgA, IgM, and IgG, as well as stronger phagocytic activity. Exacerbation of BA significantly correlates with CD8+ numbers, along with correlations between presence of anti-CMV IgG and amounts of CD16+, CD16a+ cells. |
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| format | Article |
| id | doaj.art-468906ac55114f458e78d4c7a8e00c60 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2025-03-14T02:21:06Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-468906ac55114f458e78d4c7a8e00c602025-03-11T17:59:02ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0114320120610.15789/1563-0625-2012-3-201-206344INFLUENCE OF CYTOMEGALOVIRUS PERSISTENCE UPON CLINICAL COURSE OF BRONCHIAL ASTHMA (BA) IN CHILDRENЕ. N. Suprun0V. K. Kozlov1O. I. Morozova2M. V. Efimenko3Хабаровский Филиал Дальневосточного Научного Центра Физиологии и Патологии Дыхания Сибирского Отделения Российской Академии Медицинских Наук – НИИ Охраны материнства и детства, Дальневосточный Медицинский Государственный Университет, г. ХабаровскХабаровский Филиал Дальневосточного Научного Центра Физиологии и Патологии Дыхания Сибирского Отделения Российской Академии Медицинских Наук – НИИ Охраны материнства и детства, Дальневосточный Медицинский Государственный Университет, г. ХабаровскХабаровский Филиал Дальневосточного Научного Центра Физиологии и Патологии Дыхания Сибирского Отделения Российской Академии Медицинских Наук – НИИ Охраны материнства и детства, Дальневосточный Медицинский Государственный Университет, г. ХабаровскХабаровский Филиал Дальневосточного Научного Центра Физиологии и Патологии Дыхания Сибирского Отделения Российской Академии Медицинских Наук – НИИ Охраны материнства и детства, Дальневосточный Медицинский Государственный Университет, г. ХабаровскAbstract. We have performed a study of 117 children (106 with BА, and 11, a comparison group). Upon examination of BA patients, they exhibited high rates of pneumotropic intracellular infections more frequent is found out, in comparison with healthy children, endocellular infection pathogens, in particular, cytomegalovirus (CMV), as shown by more frequent detection of specific IgM, IgG, and detection of virus-specific DNA in sputum samples of the sick children suffering with BA. In the children with BА shedding CMV DNA with sputum, a more severe clinical course of the disease was shown, as evidenced by more frequent bronchial obstruction episodes, and more severe symptoms. Decreased levels of all lymphocyte subpopulations was revealed in the patients, but in CMV-positive children, this drop was more pronounced, and accompanied by increase in CD4+ and decrease in CD8+ subpopulations, higher levels of IgA, IgM, and IgG, as well as stronger phagocytic activity. Exacerbation of BA significantly correlates with CD8+ numbers, along with correlations between presence of anti-CMV IgG and amounts of CD16+, CD16a+ cells.https://www.mimmun.ru/mimmun/article/view/347bronchial asthmacytomegalovirusimmunitychildren |
| spellingShingle | Е. N. Suprun V. K. Kozlov O. I. Morozova M. V. Efimenko INFLUENCE OF CYTOMEGALOVIRUS PERSISTENCE UPON CLINICAL COURSE OF BRONCHIAL ASTHMA (BA) IN CHILDREN Медицинская иммунология bronchial asthma cytomegalovirus immunity children |
| title | INFLUENCE OF CYTOMEGALOVIRUS PERSISTENCE UPON CLINICAL COURSE OF BRONCHIAL ASTHMA (BA) IN CHILDREN |
| title_full | INFLUENCE OF CYTOMEGALOVIRUS PERSISTENCE UPON CLINICAL COURSE OF BRONCHIAL ASTHMA (BA) IN CHILDREN |
| title_fullStr | INFLUENCE OF CYTOMEGALOVIRUS PERSISTENCE UPON CLINICAL COURSE OF BRONCHIAL ASTHMA (BA) IN CHILDREN |
| title_full_unstemmed | INFLUENCE OF CYTOMEGALOVIRUS PERSISTENCE UPON CLINICAL COURSE OF BRONCHIAL ASTHMA (BA) IN CHILDREN |
| title_short | INFLUENCE OF CYTOMEGALOVIRUS PERSISTENCE UPON CLINICAL COURSE OF BRONCHIAL ASTHMA (BA) IN CHILDREN |
| title_sort | influence of cytomegalovirus persistence upon clinical course of bronchial asthma ba in children |
| topic | bronchial asthma cytomegalovirus immunity children |
| url | https://www.mimmun.ru/mimmun/article/view/347 |
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