Black Elder and Its Constituents: Molecular Mechanisms of Action Associated with Female Reproduction
The present review summarizes the current knowledge concerning provenance, properties, physiological and therapeutic actions of elderberry and the bioactive molecules present in the plant, with emphasis on their action on female reproduction. Elderberry or black elder (<i>Sambucus nigra</i&...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/2/239 |
| _version_ | 1797477246457348096 |
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| author | Adriana Kolesarova Simona Baldovska Ladislav Kohut Alexander V. Sirotkin |
| author_facet | Adriana Kolesarova Simona Baldovska Ladislav Kohut Alexander V. Sirotkin |
| author_sort | Adriana Kolesarova |
| collection | DOAJ |
| description | The present review summarizes the current knowledge concerning provenance, properties, physiological and therapeutic actions of elderberry and the bioactive molecules present in the plant, with emphasis on their action on female reproduction. Elderberry or black elder (<i>Sambucus nigra</i> L.) attracts attention due to its easy cultivation and high availability of bioactive compounds. Most of the available data concerning black elder’s therapeutic action are focused on its effects such as activation of immune processes and anti-inflammatory processes (cytokine production, etc.) and regulation of hormones and their receptors in cancer cells. The effects of elderberry on reproduction have been poorly investigated so far. Nevertheless, conducted studies so far demonstrate the stimulatory influence of black elder extract and its constituents, such as rutin, anthocyanins and agglutinins, on the viability and steroidogenesis of healthy ovarian cells as well as their ability to promote apoptosis and reduce the viability and proliferation of ovarian cancer cells. Furthermore, the action of black elder extract and its constituent biomolecules, such as anthocyanins and lectins, on embryogenesis and the embryonal estradiol-estradiol receptor system have also been reported. The available information, despite limitations, suggest the applicability of black elder constituents for improvement of reproductive processes in animal biotechnology, animal production and assisted reproduction, as well as for prevention and treatment of reproductive disorders (including cancer) in veterinary and human medicine. |
| first_indexed | 2024-03-09T21:14:51Z |
| format | Article |
| id | doaj.art-468bde1eefcd456ba95f660e2fdd4f43 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T21:14:51Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-468bde1eefcd456ba95f660e2fdd4f432023-11-23T21:35:15ZengMDPI AGPharmaceuticals1424-82472022-02-0115223910.3390/ph15020239Black Elder and Its Constituents: Molecular Mechanisms of Action Associated with Female ReproductionAdriana Kolesarova0Simona Baldovska1Ladislav Kohut2Alexander V. Sirotkin3Institute of Applied Biology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, 949 76 Nitra, SlovakiaAgroBioTech Research Centre, Slovak University of Agriculture in Nitra, 949 76 Nitra, SlovakiaInstitute of Applied Biology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, 949 76 Nitra, SlovakiaDepartment of Zoology and Anthropology, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, 949 01 Nitra, SlovakiaThe present review summarizes the current knowledge concerning provenance, properties, physiological and therapeutic actions of elderberry and the bioactive molecules present in the plant, with emphasis on their action on female reproduction. Elderberry or black elder (<i>Sambucus nigra</i> L.) attracts attention due to its easy cultivation and high availability of bioactive compounds. Most of the available data concerning black elder’s therapeutic action are focused on its effects such as activation of immune processes and anti-inflammatory processes (cytokine production, etc.) and regulation of hormones and their receptors in cancer cells. The effects of elderberry on reproduction have been poorly investigated so far. Nevertheless, conducted studies so far demonstrate the stimulatory influence of black elder extract and its constituents, such as rutin, anthocyanins and agglutinins, on the viability and steroidogenesis of healthy ovarian cells as well as their ability to promote apoptosis and reduce the viability and proliferation of ovarian cancer cells. Furthermore, the action of black elder extract and its constituent biomolecules, such as anthocyanins and lectins, on embryogenesis and the embryonal estradiol-estradiol receptor system have also been reported. The available information, despite limitations, suggest the applicability of black elder constituents for improvement of reproductive processes in animal biotechnology, animal production and assisted reproduction, as well as for prevention and treatment of reproductive disorders (including cancer) in veterinary and human medicine.https://www.mdpi.com/1424-8247/15/2/239elderberryrutinanthocyaninsagglutininssteroidogenesisproliferation |
| spellingShingle | Adriana Kolesarova Simona Baldovska Ladislav Kohut Alexander V. Sirotkin Black Elder and Its Constituents: Molecular Mechanisms of Action Associated with Female Reproduction Pharmaceuticals elderberry rutin anthocyanins agglutinins steroidogenesis proliferation |
| title | Black Elder and Its Constituents: Molecular Mechanisms of Action Associated with Female Reproduction |
| title_full | Black Elder and Its Constituents: Molecular Mechanisms of Action Associated with Female Reproduction |
| title_fullStr | Black Elder and Its Constituents: Molecular Mechanisms of Action Associated with Female Reproduction |
| title_full_unstemmed | Black Elder and Its Constituents: Molecular Mechanisms of Action Associated with Female Reproduction |
| title_short | Black Elder and Its Constituents: Molecular Mechanisms of Action Associated with Female Reproduction |
| title_sort | black elder and its constituents molecular mechanisms of action associated with female reproduction |
| topic | elderberry rutin anthocyanins agglutinins steroidogenesis proliferation |
| url | https://www.mdpi.com/1424-8247/15/2/239 |
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