A Comparative Study between A Protein Based Amorphous Formulation and Other Dissolution Rate Enhancing Approaches: A Case Study with Rifaximin

A Comparative Study between A Protein Based Amorphous Formulation and Other Dissolution Rate Enhancing Approaches: A Case Study with Rifaximin

Amorphous solid dispersions (ASDs) based on proteins as co-formers have previously shown promising potential to improve the solubility and bioavailability of poorly water-soluble drugs. In particular, whey proteins have shown to be promising co-formers and amorphous stabilizers in ASD formulations,...

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Bibliographic Details
Main Authors: Xuezhi Zhuo, Maud Margrethe Brekstad Kjellin, Zarah Schaal, Tengyu Zhang, Korbinian Löbmann, Donglei Leng
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceutics
Subjects:
amorphous solid dispersion
β-lactoglobulin
polymer
dissolution
nanocrystal
Online Access:https://www.mdpi.com/1999-4923/15/1/126

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