Effectiveness of the COVID-19 vaccine in the Honam region of the Republic of Korea
Objectives In 2021, the effectiveness of the COVID-19 vaccine was analyzed among people living in the Honam region (Gwangju, Jeollanam-do, Jeollabuk-do, and Jeju) of the Republic of Korea. And we investigated changes in the dominant virus strain. Methods This study used the data provided by the Kore...
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| Format: | Article |
| Language: | English |
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Korea Disease Control and Prevention Agency
2023-06-01
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| Series: | Osong Public Health and Research Perspectives |
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| Online Access: | http://ophrp.org/upload/pdf/j-phrp-2022-0308.pdf |
| _version_ | 1797692857443680256 |
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| author | In-Sook Shin Yong-Pyo Lee Seung-Hoon Lee Jae-Young Lee Jong-Ha Park Yoon-Seok Chung |
| author_facet | In-Sook Shin Yong-Pyo Lee Seung-Hoon Lee Jae-Young Lee Jong-Ha Park Yoon-Seok Chung |
| author_sort | In-Sook Shin |
| collection | DOAJ |
| description | Objectives In 2021, the effectiveness of the COVID-19 vaccine was analyzed among people living in the Honam region (Gwangju, Jeollanam-do, Jeollabuk-do, and Jeju) of the Republic of Korea. And we investigated changes in the dominant virus strain. Methods This study used the data provided by the Korean Ministry of the Interior and Safety for individuals ≥12 years old in the Honam region, and the Integrated Disease and Health Management System of the Korea Centers for Disease Control and Prevention for COVID-19-vaccinated individuals as of December 31, 2021. Statistical analyzes were performed using IBM SPSS ver. 23.0. The occurrence of confirmed cases by vaccination status, the relative risk, and vaccine effectiveness by vaccine type were calculated. Results In 2021, the COVID-19 vaccination rate in Honam was 88.6%. The overall vaccine effectiveness (after 2 and 3 doses) was 98.7% (p<0.001). and the breakthrough infection rate was 0.16%. From week 21 to week 27 of 2021 (June 27 to July 3), the genome sequencing results were mostly alpha variants. The Delta variant emerged as the dominant variant after 27 weeks and the Omicron variant was found at 50 weeks (December 5–11). Conclusion Vaccine effectiveness changed with the outbreak of new variants of the virus as well as over time as antibody levels decreased. that the prevention effectiveness of vaccination in Honam was >98%, and the effect among persons who received 2 doses was >90% regardless of the vaccine type. Although vaccine effectiveness decreased because of reduced antibody levels over time (as observed in breakthrough infections), receiving a booster dose restored the neutralizing antibody levels. |
| first_indexed | 2024-03-12T02:33:39Z |
| format | Article |
| id | doaj.art-4690639e0e4741308f848bd5cf2f2518 |
| institution | Directory Open Access Journal |
| issn | 2233-6052 |
| language | English |
| last_indexed | 2024-03-12T02:33:39Z |
| publishDate | 2023-06-01 |
| publisher | Korea Disease Control and Prevention Agency |
| record_format | Article |
| series | Osong Public Health and Research Perspectives |
| spelling | doaj.art-4690639e0e4741308f848bd5cf2f25182023-09-05T01:42:51ZengKorea Disease Control and Prevention AgencyOsong Public Health and Research Perspectives2233-60522023-06-0114319720610.24171/j.phrp.2022.0308714Effectiveness of the COVID-19 vaccine in the Honam region of the Republic of KoreaIn-Sook Shin0Yong-Pyo Lee1Seung-Hoon Lee2Jae-Young Lee3Jong-Ha Park4Yoon-Seok Chung5 Division of Control for Zoonotic and Vector Borne Disease, Korea Diseases Control and Prevention Agency, Cheongju, Republic of Korea Division of Infectious Disease Diagnosis Control, Honam Regional Center for Disease Control and Prevention, Korea Diseases Control and Prevention Agency, Gwangju, Republic of Korea Division of Infectious Disease Diagnosis Control, Honam Regional Center for Disease Control and Prevention, Korea Diseases Control and Prevention Agency, Gwangju, Republic of Korea Division of Vaccine-Preventable Diseases Control and National Immunization Program, Korea Diseases Control and Prevention Agency, Cheongju, Republic of Korea Division of Infectious Disease Diagnosis Control, Honam Regional Center for Disease Control and Prevention, Korea Diseases Control and Prevention Agency, Gwangju, Republic of Korea Division of Infectious Disease Diagnosis Control, Honam Regional Center for Disease Control and Prevention, Korea Diseases Control and Prevention Agency, Gwangju, Republic of KoreaObjectives In 2021, the effectiveness of the COVID-19 vaccine was analyzed among people living in the Honam region (Gwangju, Jeollanam-do, Jeollabuk-do, and Jeju) of the Republic of Korea. And we investigated changes in the dominant virus strain. Methods This study used the data provided by the Korean Ministry of the Interior and Safety for individuals ≥12 years old in the Honam region, and the Integrated Disease and Health Management System of the Korea Centers for Disease Control and Prevention for COVID-19-vaccinated individuals as of December 31, 2021. Statistical analyzes were performed using IBM SPSS ver. 23.0. The occurrence of confirmed cases by vaccination status, the relative risk, and vaccine effectiveness by vaccine type were calculated. Results In 2021, the COVID-19 vaccination rate in Honam was 88.6%. The overall vaccine effectiveness (after 2 and 3 doses) was 98.7% (p<0.001). and the breakthrough infection rate was 0.16%. From week 21 to week 27 of 2021 (June 27 to July 3), the genome sequencing results were mostly alpha variants. The Delta variant emerged as the dominant variant after 27 weeks and the Omicron variant was found at 50 weeks (December 5–11). Conclusion Vaccine effectiveness changed with the outbreak of new variants of the virus as well as over time as antibody levels decreased. that the prevention effectiveness of vaccination in Honam was >98%, and the effect among persons who received 2 doses was >90% regardless of the vaccine type. Although vaccine effectiveness decreased because of reduced antibody levels over time (as observed in breakthrough infections), receiving a booster dose restored the neutralizing antibody levels.http://ophrp.org/upload/pdf/j-phrp-2022-0308.pdfbreakthrough infectionscovid-19strainsvaccine efficacy |
| spellingShingle | In-Sook Shin Yong-Pyo Lee Seung-Hoon Lee Jae-Young Lee Jong-Ha Park Yoon-Seok Chung Effectiveness of the COVID-19 vaccine in the Honam region of the Republic of Korea Osong Public Health and Research Perspectives breakthrough infections covid-19 strains vaccine efficacy |
| title | Effectiveness of the COVID-19 vaccine in the Honam region of the Republic of Korea |
| title_full | Effectiveness of the COVID-19 vaccine in the Honam region of the Republic of Korea |
| title_fullStr | Effectiveness of the COVID-19 vaccine in the Honam region of the Republic of Korea |
| title_full_unstemmed | Effectiveness of the COVID-19 vaccine in the Honam region of the Republic of Korea |
| title_short | Effectiveness of the COVID-19 vaccine in the Honam region of the Republic of Korea |
| title_sort | effectiveness of the covid 19 vaccine in the honam region of the republic of korea |
| topic | breakthrough infections covid-19 strains vaccine efficacy |
| url | http://ophrp.org/upload/pdf/j-phrp-2022-0308.pdf |
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