CD8+ T cell priming by dendritic cell vaccines requires antigen transfer to endogenous antigen presenting cells.

CD8+ T cell priming by dendritic cell vaccines requires antigen transfer to endogenous antigen presenting cells.

Immunotherapeutic strategies to stimulate anti-tumor immunity are promising approaches for cancer treatment. A major barrier to their success is the immunosuppressive microenvironment of tumors, which inhibits the functions of endogenous dendritic cells (DCs) that are necessary for the generation of...

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Bibliographic Details
Main Authors:	Alice W Yewdall, Scott B Drutman, Felecia Jinwala, Keith S Bahjat, Nina Bhardwaj
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2010-06-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC2886840?pdf=render

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