Endothelial dysfunction in patients with lone atrial fibrillation
BACKGROUND: Atrial fibrillation (AF) is the most common tachyarrhythmia in patients with cardiovascular diseases (CVDs) and may have significant complications such as stroke. The present study aims to evaluate endothelial dysfunction in patients with lone atrial fibrillation (LAF) through flow-media...
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| Format: | Article |
| Language: | English |
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Vesnu Publications
2020-10-01
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| Series: | ARYA Atherosclerosis |
| Subjects: | |
| Online Access: | https://arya.mui.ac.ir/article_10756_263851ad87fe9a140317705f27f43148.pdf |
| _version_ | 1811154580490158080 |
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| author | Kiyan Heshmat-Ghahdarijani Shahrzad Jangjoo Afshin Amirpoor Jamshid Najafian Alireza Khosravi Maryam Heidarpour Mostafa Hekmat Davood Shafie |
| author_facet | Kiyan Heshmat-Ghahdarijani Shahrzad Jangjoo Afshin Amirpoor Jamshid Najafian Alireza Khosravi Maryam Heidarpour Mostafa Hekmat Davood Shafie |
| author_sort | Kiyan Heshmat-Ghahdarijani |
| collection | DOAJ |
| description | BACKGROUND: Atrial fibrillation (AF) is the most common tachyarrhythmia in patients with cardiovascular diseases (CVDs) and may have significant complications such as stroke. The present study aims to evaluate endothelial dysfunction in patients with lone atrial fibrillation (LAF) through flow-mediated dilation (FMD) in the brachial artery, as a non-invasive method for evaluating functional and structural markers of endothelial dysfunction.METHODS: In this case-control study, 43 patients with LAF were selected. 51 age and sex-matched healthy individuals were selected as the control group. The brachial artery diameter of the subjects in both groups was measured through FMD. The obtained data were analyzed by SPSS software.RESULTS: Patients with LAF and healthy subjects did not have any difference in terms of gender, heart rate (HR), and systolic blood pressure (SBP) (P > 0.05 for all). FMD of the patients with AF was significantly lower (P = 0.04) than FMD of the healthy controls.CONCLUSION: Our findings showed that LAF was associated with systemic endothelial dysfunction. AF plays an important and independent role in reducing FMD. |
| first_indexed | 2024-04-10T04:18:06Z |
| format | Article |
| id | doaj.art-469181c5bda14cecb1090fdca11dc345 |
| institution | Directory Open Access Journal |
| issn | 1735-3955 2251-6638 |
| language | English |
| last_indexed | 2024-04-10T04:18:06Z |
| publishDate | 2020-10-01 |
| publisher | Vesnu Publications |
| record_format | Article |
| series | ARYA Atherosclerosis |
| spelling | doaj.art-469181c5bda14cecb1090fdca11dc3452023-03-11T12:59:12ZengVesnu PublicationsARYA Atherosclerosis1735-39552251-66382020-10-0116627828310.22122/arya.v16i6.209510756Endothelial dysfunction in patients with lone atrial fibrillationKiyan Heshmat-Ghahdarijani0Shahrzad Jangjoo1Afshin Amirpoor2Jamshid Najafian3Alireza Khosravi4Maryam Heidarpour5Mostafa Hekmat6Davood Shafie7Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranResident, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranCardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranHypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranIsfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, IranHeart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranHeart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranBACKGROUND: Atrial fibrillation (AF) is the most common tachyarrhythmia in patients with cardiovascular diseases (CVDs) and may have significant complications such as stroke. The present study aims to evaluate endothelial dysfunction in patients with lone atrial fibrillation (LAF) through flow-mediated dilation (FMD) in the brachial artery, as a non-invasive method for evaluating functional and structural markers of endothelial dysfunction.METHODS: In this case-control study, 43 patients with LAF were selected. 51 age and sex-matched healthy individuals were selected as the control group. The brachial artery diameter of the subjects in both groups was measured through FMD. The obtained data were analyzed by SPSS software.RESULTS: Patients with LAF and healthy subjects did not have any difference in terms of gender, heart rate (HR), and systolic blood pressure (SBP) (P > 0.05 for all). FMD of the patients with AF was significantly lower (P = 0.04) than FMD of the healthy controls.CONCLUSION: Our findings showed that LAF was associated with systemic endothelial dysfunction. AF plays an important and independent role in reducing FMD.https://arya.mui.ac.ir/article_10756_263851ad87fe9a140317705f27f43148.pdfatrial fibrillationarrhythmiadysfunction |
| spellingShingle | Kiyan Heshmat-Ghahdarijani Shahrzad Jangjoo Afshin Amirpoor Jamshid Najafian Alireza Khosravi Maryam Heidarpour Mostafa Hekmat Davood Shafie Endothelial dysfunction in patients with lone atrial fibrillation ARYA Atherosclerosis atrial fibrillation arrhythmia dysfunction |
| title | Endothelial dysfunction in patients with lone atrial fibrillation |
| title_full | Endothelial dysfunction in patients with lone atrial fibrillation |
| title_fullStr | Endothelial dysfunction in patients with lone atrial fibrillation |
| title_full_unstemmed | Endothelial dysfunction in patients with lone atrial fibrillation |
| title_short | Endothelial dysfunction in patients with lone atrial fibrillation |
| title_sort | endothelial dysfunction in patients with lone atrial fibrillation |
| topic | atrial fibrillation arrhythmia dysfunction |
| url | https://arya.mui.ac.ir/article_10756_263851ad87fe9a140317705f27f43148.pdf |
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