Hydroxychloroquine synergizes with the PI3K inhibitor BKM120 to exhibit antitumor efficacy independent of autophagy

Hydroxychloroquine synergizes with the PI3K inhibitor BKM120 to exhibit antitumor efficacy independent of autophagy

Abstract Background The critical role of phosphoinositide 3-kinase (PI3K) activation in tumor cell biology has prompted massive efforts to develop PI3K inhibitors (PI3Kis) for cancer therapy. However, recent results from clinical trials have shown only a modest therapeutic efficacy of single-agent P...

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Bibliographic Details
Main Authors: Xin Peng, Shaolu Zhang, Wenhui Jiao, Zhenxing Zhong, Yuqi Yang, Francois X. Claret, Moshe Elkabets, Feng Wang, Ran Wang, Yuxu Zhong, Zhe-Sheng Chen, Dexin Kong
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Hydroxychloroquine
BKM120
Autophagy
Homologous recombination repair
ROS
PI3K
Online Access:https://doi.org/10.1186/s13046-021-02176-2

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