Enzalutamide and antiretroviral drugs: a challenge for clinicians
Enzalutamide is a non-steroidal anti-androgen for metastatic prostate cancer. It has a consistent influence on several cytochromes’ activity; therefore, co-administration of ART (antiretroviral therapy) is strongly contraindicated considering the high risk of virological failure. We are describing...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Verduci Editore
2021-09-01
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| Series: | Infectious Diseases and Tropical Medicine |
| Subjects: | |
| Online Access: | https://www.infectiousjournal.com/wp-content/uploads/sites/6/2021/09/e750.pdf |
| _version_ | 1797956944461299712 |
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| author | G. Gardini I. Izzo G. Del Fabro I. El-Hamad F. Castelli |
| author_facet | G. Gardini I. Izzo G. Del Fabro I. El-Hamad F. Castelli |
| author_sort | G. Gardini |
| collection | DOAJ |
| description | Enzalutamide is a non-steroidal anti-androgen for metastatic prostate cancer. It has a consistent influence on several cytochromes’ activity; therefore, co-administration of ART (antiretroviral therapy) is strongly contraindicated considering the high risk of virological failure.
We are describing how we successfully used Therapeutic Drug Monitoring (TDM) to modify ART dosing in an HIV-infected patient affected by metastatic prostate cancer who needed long-term treatment with enzalutamide. |
| first_indexed | 2024-04-10T23:56:35Z |
| format | Article |
| id | doaj.art-4692959402b945f7a74f1724118fd53e |
| institution | Directory Open Access Journal |
| issn | 2379-4054 |
| language | English |
| last_indexed | 2024-04-10T23:56:35Z |
| publishDate | 2021-09-01 |
| publisher | Verduci Editore |
| record_format | Article |
| series | Infectious Diseases and Tropical Medicine |
| spelling | doaj.art-4692959402b945f7a74f1724118fd53e2023-01-10T10:49:57ZengVerduci EditoreInfectious Diseases and Tropical Medicine2379-40542021-09-01710.32113/idtm_20219_750750Enzalutamide and antiretroviral drugs: a challenge for cliniciansG. Gardini0I. Izzo1G. Del Fabro2I. El-Hamad3F. Castelli4Division of Infectious and Tropical Diseases, ASST Spedali Civili Hospital, Brescia, ItalyDivision of Infectious and Tropical Diseases, ASST Spedali Civili Hospital, Brescia, ItalyDivision of Infectious and Tropical Diseases, ASST Spedali Civili Hospital, Brescia, ItalyDivision of Infectious and Tropical Diseases, ASST Spedali Civili Hospital, Brescia, ItalyDivision of Infectious and Tropical Diseases, ASST Spedali Civili Hospital, Brescia, ItalyEnzalutamide is a non-steroidal anti-androgen for metastatic prostate cancer. It has a consistent influence on several cytochromes’ activity; therefore, co-administration of ART (antiretroviral therapy) is strongly contraindicated considering the high risk of virological failure. We are describing how we successfully used Therapeutic Drug Monitoring (TDM) to modify ART dosing in an HIV-infected patient affected by metastatic prostate cancer who needed long-term treatment with enzalutamide.https://www.infectiousjournal.com/wp-content/uploads/sites/6/2021/09/e750.pdfenzalutamidetdmarthivdrug interactions. |
| spellingShingle | G. Gardini I. Izzo G. Del Fabro I. El-Hamad F. Castelli Enzalutamide and antiretroviral drugs: a challenge for clinicians Infectious Diseases and Tropical Medicine enzalutamide tdm art hiv drug interactions. |
| title | Enzalutamide and antiretroviral drugs: a challenge for clinicians |
| title_full | Enzalutamide and antiretroviral drugs: a challenge for clinicians |
| title_fullStr | Enzalutamide and antiretroviral drugs: a challenge for clinicians |
| title_full_unstemmed | Enzalutamide and antiretroviral drugs: a challenge for clinicians |
| title_short | Enzalutamide and antiretroviral drugs: a challenge for clinicians |
| title_sort | enzalutamide and antiretroviral drugs a challenge for clinicians |
| topic | enzalutamide tdm art hiv drug interactions. |
| url | https://www.infectiousjournal.com/wp-content/uploads/sites/6/2021/09/e750.pdf |
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