Health Outcomes at School Age among Children Who Are HIV-Exposed but Uninfected with Detected Mitochondrial DNA Depletion at One Year
Infant antiretroviral (ARV) prophylaxis given to children who are human immunodeficiency virus (HIV)-exposed but uninfected (CHEU) to prevent HIV transmission through breastfeeding previously proved its efficacy in the fight against the pediatric epidemic. However, few studies have investigated the...
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| Format: | Article |
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MDPI AG
2020-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/11/3680 |
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| author | Audrey Monnin Nicolas Nagot Sabrina Eymard-Duvernay Nicolas Meda James K. Tumwine Thorkild Tylleskär Philippe Van de Perre Jean-Pierre Molès |
| author_facet | Audrey Monnin Nicolas Nagot Sabrina Eymard-Duvernay Nicolas Meda James K. Tumwine Thorkild Tylleskär Philippe Van de Perre Jean-Pierre Molès |
| author_sort | Audrey Monnin |
| collection | DOAJ |
| description | Infant antiretroviral (ARV) prophylaxis given to children who are human immunodeficiency virus (HIV)-exposed but uninfected (CHEU) to prevent HIV transmission through breastfeeding previously proved its efficacy in the fight against the pediatric epidemic. However, few studies have investigated the short- and long-term safety of prophylactic regimens. We previously reported a decrease of mitochondrial DNA (mtDNA) content among CHEU who received one year of lamivudine (3TC) or lopinavir-boosted ritonavir (LPV/r) as infant prophylaxis. We aimed to describe mtDNA content at six years of age among these CHEU, including those for whom we identified mtDNA depletion at week 50 (decrease superior or equal to 50% from baseline), and to compare the two prophylactic drugs. We also addressed the association between mtDNA depletion at week 50 with growth, clinical, and neuropsychological outcomes at year 6. Quantitative PCR was used to measure mtDNA content in whole blood of CHEU seven days after birth, at week 50, and at year 6. Among CHEU with identified mtDNA depletion at week 50 (<i>n</i> = 17), only one had a persistent mtDNA content decrease at year 6. No difference between prophylactic drugs was observed. mtDNA depletion was not associated with growth, clinical, or neuropsychological outcomes at year 6. This study brought reassuring data concerning the safety of infant 3TC or LPV/r prophylaxis. |
| first_indexed | 2024-03-10T14:48:42Z |
| format | Article |
| id | doaj.art-4692dd84e8e5447ba8cc4947e6af7e55 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T14:48:42Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-4692dd84e8e5447ba8cc4947e6af7e552023-11-20T21:09:20ZengMDPI AGJournal of Clinical Medicine2077-03832020-11-01911368010.3390/jcm9113680Health Outcomes at School Age among Children Who Are HIV-Exposed but Uninfected with Detected Mitochondrial DNA Depletion at One YearAudrey Monnin0Nicolas Nagot1Sabrina Eymard-Duvernay2Nicolas Meda3James K. Tumwine4Thorkild Tylleskär5Philippe Van de Perre6Jean-Pierre Molès7Pathogenèse et Contrôle des Infections Chroniques, INSERM U1058, Université Montpellier, Etablissement Français du Sang, 34934 Montpellier, FrancePathogenèse et Contrôle des Infections Chroniques, INSERM U1058, Université Montpellier, Centre Hospitalier Universitaire, 34934 Montpellier, FrancePathogenèse et Contrôle des Infections Chroniques, INSERM U1058, Université Montpellier, Etablissement Français du Sang, 34934 Montpellier, FranceCentre MURAZ, Bobo-Dioulasso 01 01 B.P. 390, Burkina FasoDepartment of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University, Kampala 7062, UgandaCentre for International Health, Faculty of Medicine, University of Bergen, 5009 Bergen, NorwayPathogenèse et Contrôle des Infections Chroniques, INSERM U1058, Université Montpellier, Centre Hospitalier Universitaire, 34934 Montpellier, FrancePathogenèse et Contrôle des Infections Chroniques, INSERM U1058, Université Montpellier, Etablissement Français du Sang, 34934 Montpellier, FranceInfant antiretroviral (ARV) prophylaxis given to children who are human immunodeficiency virus (HIV)-exposed but uninfected (CHEU) to prevent HIV transmission through breastfeeding previously proved its efficacy in the fight against the pediatric epidemic. However, few studies have investigated the short- and long-term safety of prophylactic regimens. We previously reported a decrease of mitochondrial DNA (mtDNA) content among CHEU who received one year of lamivudine (3TC) or lopinavir-boosted ritonavir (LPV/r) as infant prophylaxis. We aimed to describe mtDNA content at six years of age among these CHEU, including those for whom we identified mtDNA depletion at week 50 (decrease superior or equal to 50% from baseline), and to compare the two prophylactic drugs. We also addressed the association between mtDNA depletion at week 50 with growth, clinical, and neuropsychological outcomes at year 6. Quantitative PCR was used to measure mtDNA content in whole blood of CHEU seven days after birth, at week 50, and at year 6. Among CHEU with identified mtDNA depletion at week 50 (<i>n</i> = 17), only one had a persistent mtDNA content decrease at year 6. No difference between prophylactic drugs was observed. mtDNA depletion was not associated with growth, clinical, or neuropsychological outcomes at year 6. This study brought reassuring data concerning the safety of infant 3TC or LPV/r prophylaxis.https://www.mdpi.com/2077-0383/9/11/3680mitochondrial DNAdepletionHIV-exposed uninfected childrenlopinavir/ritonavirlamivudinegrowth |
| spellingShingle | Audrey Monnin Nicolas Nagot Sabrina Eymard-Duvernay Nicolas Meda James K. Tumwine Thorkild Tylleskär Philippe Van de Perre Jean-Pierre Molès Health Outcomes at School Age among Children Who Are HIV-Exposed but Uninfected with Detected Mitochondrial DNA Depletion at One Year Journal of Clinical Medicine mitochondrial DNA depletion HIV-exposed uninfected children lopinavir/ritonavir lamivudine growth |
| title | Health Outcomes at School Age among Children Who Are HIV-Exposed but Uninfected with Detected Mitochondrial DNA Depletion at One Year |
| title_full | Health Outcomes at School Age among Children Who Are HIV-Exposed but Uninfected with Detected Mitochondrial DNA Depletion at One Year |
| title_fullStr | Health Outcomes at School Age among Children Who Are HIV-Exposed but Uninfected with Detected Mitochondrial DNA Depletion at One Year |
| title_full_unstemmed | Health Outcomes at School Age among Children Who Are HIV-Exposed but Uninfected with Detected Mitochondrial DNA Depletion at One Year |
| title_short | Health Outcomes at School Age among Children Who Are HIV-Exposed but Uninfected with Detected Mitochondrial DNA Depletion at One Year |
| title_sort | health outcomes at school age among children who are hiv exposed but uninfected with detected mitochondrial dna depletion at one year |
| topic | mitochondrial DNA depletion HIV-exposed uninfected children lopinavir/ritonavir lamivudine growth |
| url | https://www.mdpi.com/2077-0383/9/11/3680 |
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