Recent Advances in Mouse Models of Sjögren's Syndrome
Sjögren's syndrome (SS) is a complex rheumatoid disease that mainly affects exocrine glands, resulting in xerostomia (dry mouth) and xerophthalmia (dry eye). SS is characterized by autoantibodies, infiltration into exocrine glands, and ectopic expression of MHC II molecules on glandular epithel...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.01158/full |
| _version_ | 1828487138510897152 |
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| author | Yunzhen Gao Yan Chen Zhongjian Zhang Xinhua Yu Junfeng Zheng |
| author_facet | Yunzhen Gao Yan Chen Zhongjian Zhang Xinhua Yu Junfeng Zheng |
| author_sort | Yunzhen Gao |
| collection | DOAJ |
| description | Sjögren's syndrome (SS) is a complex rheumatoid disease that mainly affects exocrine glands, resulting in xerostomia (dry mouth) and xerophthalmia (dry eye). SS is characterized by autoantibodies, infiltration into exocrine glands, and ectopic expression of MHC II molecules on glandular epithelial cells. In contrast to the well-characterized clinical and immunological features, the etiology and pathogenesis of SS remain largely unknown. Animal models are powerful research tools for elucidating the pathogenesis of human diseases. To date, many mouse models of SS, including induced models, in which disease is induced in mice, and genetic models, in which mice spontaneously develop SS-like disease, have been established. These mouse models have provided new insight into the pathogenesis of SS. In this review, we aim to provide a comprehensive overview of recent advances in the field of experimental SS. |
| first_indexed | 2024-12-11T09:45:22Z |
| format | Article |
| id | doaj.art-4692f447d40b4769bb6a256bb380364b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T09:45:22Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-4692f447d40b4769bb6a256bb380364b2022-12-22T01:12:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-06-011110.3389/fimmu.2020.01158471903Recent Advances in Mouse Models of Sjögren's SyndromeYunzhen Gao0Yan Chen1Zhongjian Zhang2Xinhua Yu3Junfeng Zheng4Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, ChinaInstitute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, ChinaInstitute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, ChinaPriority Area Asthma & Allergy, Research Center Borstel, Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), Borstel, GermanyInstitute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, ChinaSjögren's syndrome (SS) is a complex rheumatoid disease that mainly affects exocrine glands, resulting in xerostomia (dry mouth) and xerophthalmia (dry eye). SS is characterized by autoantibodies, infiltration into exocrine glands, and ectopic expression of MHC II molecules on glandular epithelial cells. In contrast to the well-characterized clinical and immunological features, the etiology and pathogenesis of SS remain largely unknown. Animal models are powerful research tools for elucidating the pathogenesis of human diseases. To date, many mouse models of SS, including induced models, in which disease is induced in mice, and genetic models, in which mice spontaneously develop SS-like disease, have been established. These mouse models have provided new insight into the pathogenesis of SS. In this review, we aim to provide a comprehensive overview of recent advances in the field of experimental SS.https://www.frontiersin.org/article/10.3389/fimmu.2020.01158/fullSjögren's syndromemouse modelexocrine glandspathogenesisautoimmune disease |
| spellingShingle | Yunzhen Gao Yan Chen Zhongjian Zhang Xinhua Yu Junfeng Zheng Recent Advances in Mouse Models of Sjögren's Syndrome Frontiers in Immunology Sjögren's syndrome mouse model exocrine glands pathogenesis autoimmune disease |
| title | Recent Advances in Mouse Models of Sjögren's Syndrome |
| title_full | Recent Advances in Mouse Models of Sjögren's Syndrome |
| title_fullStr | Recent Advances in Mouse Models of Sjögren's Syndrome |
| title_full_unstemmed | Recent Advances in Mouse Models of Sjögren's Syndrome |
| title_short | Recent Advances in Mouse Models of Sjögren's Syndrome |
| title_sort | recent advances in mouse models of sjogren s syndrome |
| topic | Sjögren's syndrome mouse model exocrine glands pathogenesis autoimmune disease |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.01158/full |
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