Through the layers: how macrophages drive atherosclerosis across the vessel wall
Cardiovascular disease (CVD) accounts for almost half of all deaths related to non-communicable disease worldwide, making it the single largest global cause of mortality. Although the risk factors for coronary artery disease — the most common cause of CVD — are well known and include hypertension, h...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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American Society for Clinical Investigation
2022-05-01
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| Series: | The Journal of Clinical Investigation |
| Online Access: | https://doi.org/10.1172/JCI157011 |
| _version_ | 1818242793746726912 |
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| author | Leah I. Susser Katey J. Rayner |
| author_facet | Leah I. Susser Katey J. Rayner |
| author_sort | Leah I. Susser |
| collection | DOAJ |
| description | Cardiovascular disease (CVD) accounts for almost half of all deaths related to non-communicable disease worldwide, making it the single largest global cause of mortality. Although the risk factors for coronary artery disease — the most common cause of CVD — are well known and include hypertension, high cholesterol, age, and genetics, CVDs are now recognized as chronic inflammatory conditions. Arterial blockages, known as atherosclerosis, develop due to excess cholesterol accumulating within the arterial wall, creating a perpetually inflammatory state. The normally quiescent intimal layer of the vessel wall becomes laden with inflammatory cells, which alters the surrounding endothelial, smooth muscle, and extracellular matrix components to propagate disease. Macrophages, which can be either tissue resident or monocyte derived, are a key player in atherosclerotic disease progression and regression, and the understanding of their functions and origins continues to evolve with the use of deep phenotyping methodologies. This Review outlines how macrophages interact with each layer of the developing atherosclerotic plaque and discusses new concepts that are challenging our previous views on how macrophages function and our evolving understanding of the contribution of macrophages to disease. |
| first_indexed | 2024-12-12T13:50:53Z |
| format | Article |
| id | doaj.art-469350230abb4486b7e8afdc9a204a5f |
| institution | Directory Open Access Journal |
| issn | 1558-8238 |
| language | English |
| last_indexed | 2024-12-12T13:50:53Z |
| publishDate | 2022-05-01 |
| publisher | American Society for Clinical Investigation |
| record_format | Article |
| series | The Journal of Clinical Investigation |
| spelling | doaj.art-469350230abb4486b7e8afdc9a204a5f2022-12-22T00:22:34ZengAmerican Society for Clinical InvestigationThe Journal of Clinical Investigation1558-82382022-05-011329Through the layers: how macrophages drive atherosclerosis across the vessel wallLeah I. SusserKatey J. RaynerCardiovascular disease (CVD) accounts for almost half of all deaths related to non-communicable disease worldwide, making it the single largest global cause of mortality. Although the risk factors for coronary artery disease — the most common cause of CVD — are well known and include hypertension, high cholesterol, age, and genetics, CVDs are now recognized as chronic inflammatory conditions. Arterial blockages, known as atherosclerosis, develop due to excess cholesterol accumulating within the arterial wall, creating a perpetually inflammatory state. The normally quiescent intimal layer of the vessel wall becomes laden with inflammatory cells, which alters the surrounding endothelial, smooth muscle, and extracellular matrix components to propagate disease. Macrophages, which can be either tissue resident or monocyte derived, are a key player in atherosclerotic disease progression and regression, and the understanding of their functions and origins continues to evolve with the use of deep phenotyping methodologies. This Review outlines how macrophages interact with each layer of the developing atherosclerotic plaque and discusses new concepts that are challenging our previous views on how macrophages function and our evolving understanding of the contribution of macrophages to disease.https://doi.org/10.1172/JCI157011 |
| spellingShingle | Leah I. Susser Katey J. Rayner Through the layers: how macrophages drive atherosclerosis across the vessel wall The Journal of Clinical Investigation |
| title | Through the layers: how macrophages drive atherosclerosis across the vessel wall |
| title_full | Through the layers: how macrophages drive atherosclerosis across the vessel wall |
| title_fullStr | Through the layers: how macrophages drive atherosclerosis across the vessel wall |
| title_full_unstemmed | Through the layers: how macrophages drive atherosclerosis across the vessel wall |
| title_short | Through the layers: how macrophages drive atherosclerosis across the vessel wall |
| title_sort | through the layers how macrophages drive atherosclerosis across the vessel wall |
| url | https://doi.org/10.1172/JCI157011 |
| work_keys_str_mv | AT leahisusser throughthelayershowmacrophagesdriveatherosclerosisacrossthevesselwall AT kateyjrayner throughthelayershowmacrophagesdriveatherosclerosisacrossthevesselwall |