Treatment of a life-threatening dapsone intoxication
The case report describes a case of a severe dapsone (more than 200 tablets dapsone 100 mg) and mild methotrexate intoxication (10 tablets methotrexate 10 mg) as an attempt to commit suicide, resulting in severe cyanosis with elevation in methemoglobin concentration, treated with methylene blue, asc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
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| Series: | Toxicology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750023001191 |
| _version_ | 1797386765423607808 |
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| author | M.H. Veerman T. van Gelder R. Sneijder C. Bethlehem |
| author_facet | M.H. Veerman T. van Gelder R. Sneijder C. Bethlehem |
| author_sort | M.H. Veerman |
| collection | DOAJ |
| description | The case report describes a case of a severe dapsone (more than 200 tablets dapsone 100 mg) and mild methotrexate intoxication (10 tablets methotrexate 10 mg) as an attempt to commit suicide, resulting in severe cyanosis with elevation in methemoglobin concentration, treated with methylene blue, ascorbic acid, folinic acid, multidose activated charcoal and hemodialysis. Measurements of blood gases, dapsone and methotrexate levels were performed. Furthermore a hepatitis, pulmonary artery thrombus and a strange taste sensation were diagnosed, probably related to dapsone. The patient recovered and was discharged from hospital after five days. Acute intoxication from excessive dapsone intake is uncommon and clear treatment guidelines are lacking. We here report the treatment modalities as a result of a dapsone intoxication, including the effects on the overall condition of the patient. |
| first_indexed | 2024-03-08T22:14:04Z |
| format | Article |
| id | doaj.art-4694f194456e453eb2167206a412391e |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-03-08T22:14:04Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-4694f194456e453eb2167206a412391e2023-12-19T04:17:02ZengElsevierToxicology Reports2214-75002023-12-0111374377Treatment of a life-threatening dapsone intoxicationM.H. Veerman0T. van Gelder1R. Sneijder2C. Bethlehem3Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, the Netherlands; Correspondence to: Department of Hospital Pharmacy, Erasmus University Medical Center, Doctor Molewaterplein 40, 3015 GD Rotterdam, the Netherlands.Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, the NetherlandsDepartment of Intensive Care, ADRZ Medical Center, Goes, the NetherlandsDepartment of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, the NetherlandsThe case report describes a case of a severe dapsone (more than 200 tablets dapsone 100 mg) and mild methotrexate intoxication (10 tablets methotrexate 10 mg) as an attempt to commit suicide, resulting in severe cyanosis with elevation in methemoglobin concentration, treated with methylene blue, ascorbic acid, folinic acid, multidose activated charcoal and hemodialysis. Measurements of blood gases, dapsone and methotrexate levels were performed. Furthermore a hepatitis, pulmonary artery thrombus and a strange taste sensation were diagnosed, probably related to dapsone. The patient recovered and was discharged from hospital after five days. Acute intoxication from excessive dapsone intake is uncommon and clear treatment guidelines are lacking. We here report the treatment modalities as a result of a dapsone intoxication, including the effects on the overall condition of the patient.http://www.sciencedirect.com/science/article/pii/S2214750023001191PharmacokineticsToxicologyPoisoningDapsoneMethotrexateMethemoglobinemia |
| spellingShingle | M.H. Veerman T. van Gelder R. Sneijder C. Bethlehem Treatment of a life-threatening dapsone intoxication Toxicology Reports Pharmacokinetics Toxicology Poisoning Dapsone Methotrexate Methemoglobinemia |
| title | Treatment of a life-threatening dapsone intoxication |
| title_full | Treatment of a life-threatening dapsone intoxication |
| title_fullStr | Treatment of a life-threatening dapsone intoxication |
| title_full_unstemmed | Treatment of a life-threatening dapsone intoxication |
| title_short | Treatment of a life-threatening dapsone intoxication |
| title_sort | treatment of a life threatening dapsone intoxication |
| topic | Pharmacokinetics Toxicology Poisoning Dapsone Methotrexate Methemoglobinemia |
| url | http://www.sciencedirect.com/science/article/pii/S2214750023001191 |
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