Protective Effects of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity in Rats
Drug-induced liver injury (DILI) is the major health problem that resulted from uses of many drugs especially from serious adverse effect of antituberculosis (ATT) drugs. forty eight rats (200-250g) were allocated into six groups (8 rats in each group), and treated as follow: group I: received norma...
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| Format: | Article |
| Language: | English |
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Egyptian Society for Animal Management
2019-10-01
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| Series: | Journal of Applied Veterinary Sciences |
| Subjects: | |
| Online Access: | https://javs.journals.ekb.eg/article_63436.html |
| _version_ | 1818401132175687680 |
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| author | Abdel-Hameed M.Fayed Abeer A. A. Salama Ismaiel E Ismaiel Taha A. Attia Elbatran Seham A Azza Hassan |
| author_facet | Abdel-Hameed M.Fayed Abeer A. A. Salama Ismaiel E Ismaiel Taha A. Attia Elbatran Seham A Azza Hassan |
| author_sort | Abdel-Hameed M.Fayed |
| collection | DOAJ |
| description | Drug-induced liver injury (DILI) is the major health problem that resulted from uses of many drugs especially from serious adverse effect of antituberculosis (ATT) drugs. forty eight rats (200-250g) were allocated into six groups (8 rats in each group), and treated as follow: group I: received normal saline orally; group II: received INH/RFP (50 mg/Kg/day of each) for 28 days orally; group III: received Silymarin (50 mg/kg/day) + INH/RFP for 28 days orally; group IV: received SNME(250 mg/Kg/day) + INH/RFP for 28 days orally; group V: received SNME (500 mg/Kg/day) + INH/RFP for 28 days orally; group VI, received SNME (1000 mg/Kg/day) + INH/RFP for 28 days orally. Co-administration of herbal plant (SNME) with INH/RFP reduced elevated serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and (bilirubin total &direct) levels but also decreased the elevated malondialdehyde (MDA) & tumor necrosis factor-α (TNF-α) contents in liver homogenate. Moreover, co-administration of herbal plant (SNME) with INH/RFP increased glutathione peroxidase (GPX) & adiponectin activity. Solanum nigrum administration to rats, in present study, led to a remarkable alteration of histological changes observed in INH/RFP group. It is concluded that Solanum nigrum might be considered as adjuvant drug in treatment of liver disorder and/or as hepatoprotective therapy with anti-tubercular drugs. |
| first_indexed | 2024-12-14T07:47:36Z |
| format | Article |
| id | doaj.art-46969e3182144d0b80691eb22737b306 |
| institution | Directory Open Access Journal |
| issn | 1687-4072 2090-3308 |
| language | English |
| last_indexed | 2024-12-14T07:47:36Z |
| publishDate | 2019-10-01 |
| publisher | Egyptian Society for Animal Management |
| record_format | Article |
| series | Journal of Applied Veterinary Sciences |
| spelling | doaj.art-46969e3182144d0b80691eb22737b3062022-12-21T23:10:50ZengEgyptian Society for Animal ManagementJournal of Applied Veterinary Sciences1687-40722090-33082019-10-01425261https://dx.doi.org/10.21608/javs.2019.63436Protective Effects of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity in RatsAbdel-Hameed M.Fayed0Abeer A. A. Salama1Ismaiel E Ismaiel2Taha A. Attia3Elbatran Seham A4Azza Hassan5Pharmacology Department National Research Centre, Giza, EgyptPharmacology Department National Research Centre, Giza, EgyptPharmacology Department National Research Centre, Giza, EgyptPharmacology Department, Faculty of Vet. Med., El-Sadat University, Minoufiya, EgyptPharmacology Department National Research Centre, Giza, EgyptPathology Department, Faculty of Vet. Med., Cairo University, Giza, EgyptDrug-induced liver injury (DILI) is the major health problem that resulted from uses of many drugs especially from serious adverse effect of antituberculosis (ATT) drugs. forty eight rats (200-250g) were allocated into six groups (8 rats in each group), and treated as follow: group I: received normal saline orally; group II: received INH/RFP (50 mg/Kg/day of each) for 28 days orally; group III: received Silymarin (50 mg/kg/day) + INH/RFP for 28 days orally; group IV: received SNME(250 mg/Kg/day) + INH/RFP for 28 days orally; group V: received SNME (500 mg/Kg/day) + INH/RFP for 28 days orally; group VI, received SNME (1000 mg/Kg/day) + INH/RFP for 28 days orally. Co-administration of herbal plant (SNME) with INH/RFP reduced elevated serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and (bilirubin total &direct) levels but also decreased the elevated malondialdehyde (MDA) & tumor necrosis factor-α (TNF-α) contents in liver homogenate. Moreover, co-administration of herbal plant (SNME) with INH/RFP increased glutathione peroxidase (GPX) & adiponectin activity. Solanum nigrum administration to rats, in present study, led to a remarkable alteration of histological changes observed in INH/RFP group. It is concluded that Solanum nigrum might be considered as adjuvant drug in treatment of liver disorder and/or as hepatoprotective therapy with anti-tubercular drugs.https://javs.journals.ekb.eg/article_63436.htmladiponectinhepatotoxicityisoniazidratsrifampicinsolanum nigrum |
| spellingShingle | Abdel-Hameed M.Fayed Abeer A. A. Salama Ismaiel E Ismaiel Taha A. Attia Elbatran Seham A Azza Hassan Protective Effects of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity in Rats Journal of Applied Veterinary Sciences adiponectin hepatotoxicity isoniazid rats rifampicin solanum nigrum |
| title | Protective Effects of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity in Rats |
| title_full | Protective Effects of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity in Rats |
| title_fullStr | Protective Effects of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity in Rats |
| title_full_unstemmed | Protective Effects of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity in Rats |
| title_short | Protective Effects of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity in Rats |
| title_sort | protective effects of solanium nigrum methanolic extract against isoniazid rifampicin induced hepatotoxicity in rats |
| topic | adiponectin hepatotoxicity isoniazid rats rifampicin solanum nigrum |
| url | https://javs.journals.ekb.eg/article_63436.html |
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