Changes in antibiotic residues and the gut microbiota during ciprofloxacin administration throughout Silkie chicken development
ABSTRACT: The use of antibiotics leads to antibiotic residues in livestock and poultry products, adversely affecting human health. Ciprofloxacin (CFX) is a broad-spectrum antibiotic shared between animals and humans that is useful in treatments besides infections. However, changes in the gut microbi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Poultry Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579122005624 |
| _version_ | 1828281127915225088 |
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| author | Yushan Yuan Peng Chen Ying Li Jiaheng Cheng Xia Yan Chenglong Luo Dingming Shu Hao Qu Jian Ji |
| author_facet | Yushan Yuan Peng Chen Ying Li Jiaheng Cheng Xia Yan Chenglong Luo Dingming Shu Hao Qu Jian Ji |
| author_sort | Yushan Yuan |
| collection | DOAJ |
| description | ABSTRACT: The use of antibiotics leads to antibiotic residues in livestock and poultry products, adversely affecting human health. Ciprofloxacin (CFX) is a broad-spectrum antibiotic shared between animals and humans that is useful in treatments besides infections. However, changes in the gut microbiota caused by CFX and the possible link with the elimination of CFX residues have not been investigated. Herein, we used the Silkie chicken model to study the changes in the gut microbiota during the entire CFX-metabolic repertoire. We detected CFX residues in different tissues and showed that the elimination time of CFX from different tissues was dissimilar (liver > kidney > chest muscle > skin). Analysis of liver and kidney injury biomarkers and plasma antioxidant indices indicated slight hepatotoxicity and nephrotoxicity in the Silkie chickens. Importantly, the changes in the gut microbial community predominantly occurred early in the metabolic process. Correlation analysis revealed that the particular bacterial microbiota were associated with the pharmacokinetics of CFX in different Silkie chicken tissues (e.g., aerobic bacteria, including Escherichia and Coprococcus, and anaerobic bacteria, including Fusobacterium, Ruminococcus, Bifidobacterium, and Eubacterium). Collectively, certain microbiota may boost antibiotic metabolism and participate in restoring the microbial consortia after CFX is metabolized. Therefore, regulating the core intestinal microbiota may reduce foodborne antibiotics and accelerate the development of drug resistance. |
| first_indexed | 2024-04-13T08:11:07Z |
| format | Article |
| id | doaj.art-4697022db78b413cb540ec749086584c |
| institution | Directory Open Access Journal |
| issn | 0032-5791 |
| language | English |
| last_indexed | 2024-04-13T08:11:07Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Poultry Science |
| spelling | doaj.art-4697022db78b413cb540ec749086584c2022-12-22T02:54:59ZengElsevierPoultry Science0032-57912023-01-011021102267Changes in antibiotic residues and the gut microbiota during ciprofloxacin administration throughout Silkie chicken developmentYushan Yuan0Peng Chen1Ying Li2Jiaheng Cheng3Xia Yan4Chenglong Luo5Dingming Shu6Hao Qu7Jian Ji8State Key Laboratory of Livestock and Poultry Breeding, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, ChinaState Key Laboratory of Livestock and Poultry Breeding, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, ChinaState Key Laboratory of Livestock and Poultry Breeding, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, ChinaState Key Laboratory of Livestock and Poultry Breeding, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, ChinaState Key Laboratory of Livestock and Poultry Breeding, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, ChinaState Key Laboratory of Livestock and Poultry Breeding, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, ChinaState Key Laboratory of Livestock and Poultry Breeding, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, ChinaState Key Laboratory of Livestock and Poultry Breeding, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, ChinaCorresponding author:; State Key Laboratory of Livestock and Poultry Breeding, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, ChinaABSTRACT: The use of antibiotics leads to antibiotic residues in livestock and poultry products, adversely affecting human health. Ciprofloxacin (CFX) is a broad-spectrum antibiotic shared between animals and humans that is useful in treatments besides infections. However, changes in the gut microbiota caused by CFX and the possible link with the elimination of CFX residues have not been investigated. Herein, we used the Silkie chicken model to study the changes in the gut microbiota during the entire CFX-metabolic repertoire. We detected CFX residues in different tissues and showed that the elimination time of CFX from different tissues was dissimilar (liver > kidney > chest muscle > skin). Analysis of liver and kidney injury biomarkers and plasma antioxidant indices indicated slight hepatotoxicity and nephrotoxicity in the Silkie chickens. Importantly, the changes in the gut microbial community predominantly occurred early in the metabolic process. Correlation analysis revealed that the particular bacterial microbiota were associated with the pharmacokinetics of CFX in different Silkie chicken tissues (e.g., aerobic bacteria, including Escherichia and Coprococcus, and anaerobic bacteria, including Fusobacterium, Ruminococcus, Bifidobacterium, and Eubacterium). Collectively, certain microbiota may boost antibiotic metabolism and participate in restoring the microbial consortia after CFX is metabolized. Therefore, regulating the core intestinal microbiota may reduce foodborne antibiotics and accelerate the development of drug resistance.http://www.sciencedirect.com/science/article/pii/S0032579122005624ciprofloxacinpharmacokineticsgut microbiotametabolismSilkie chicken |
| spellingShingle | Yushan Yuan Peng Chen Ying Li Jiaheng Cheng Xia Yan Chenglong Luo Dingming Shu Hao Qu Jian Ji Changes in antibiotic residues and the gut microbiota during ciprofloxacin administration throughout Silkie chicken development Poultry Science ciprofloxacin pharmacokinetics gut microbiota metabolism Silkie chicken |
| title | Changes in antibiotic residues and the gut microbiota during ciprofloxacin administration throughout Silkie chicken development |
| title_full | Changes in antibiotic residues and the gut microbiota during ciprofloxacin administration throughout Silkie chicken development |
| title_fullStr | Changes in antibiotic residues and the gut microbiota during ciprofloxacin administration throughout Silkie chicken development |
| title_full_unstemmed | Changes in antibiotic residues and the gut microbiota during ciprofloxacin administration throughout Silkie chicken development |
| title_short | Changes in antibiotic residues and the gut microbiota during ciprofloxacin administration throughout Silkie chicken development |
| title_sort | changes in antibiotic residues and the gut microbiota during ciprofloxacin administration throughout silkie chicken development |
| topic | ciprofloxacin pharmacokinetics gut microbiota metabolism Silkie chicken |
| url | http://www.sciencedirect.com/science/article/pii/S0032579122005624 |
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