Indole-3-carbinol attenuates lipopolysaccharide-induced acute respiratory distress syndrome through activation of AhR: role of CCR2+ monocyte activation and recruitment in the regulation of CXCR2+ neutrophils in the lungs

Indole-3-carbinol attenuates lipopolysaccharide-induced acute respiratory distress syndrome through activation of AhR: role of CCR2+ monocyte activation and recruitment in the regulation of CXCR2+ neutrophils in the lungs

IntroductionIndole-3-carbinol (I3C) is found in cruciferous vegetables and used as a dietary supplement. It is known to act as a ligand for aryl hydrocarbon receptor (AhR). In the current study, we investigated the role of AhR and the ability of I3C to attenuate LPS-induced Acute Respiratory Distr...

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Bibliographic Details
Main Authors:	Bryan Latrell Holloman, Kiesha Wilson, Alkeiver Cannon, Mitzi Nagarkatti, Prakash S. Nagarkatti
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-03-01
Series:	Frontiers in Immunology
Subjects:	ARDS LPS CCR2 lung inflammation CXCL3
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1330373/full

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