Serum cortisol of Sahel goats following rumenotomy with assorted anaesthetics and sutures
The utmost need for pragmatic combination of surgical sutures and local anaesthetic that would evoke minimal post-surgical stress response and allow uncomplicated healing is essential for successful surgeries. Fifteen Sahel goats were randomly allocated into three groups A, B and C to quantitatively...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2016-06-01
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| Series: | International Journal of Veterinary Science and Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2314459916300138 |
| _version_ | 1818808490737532928 |
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| author | Abubakar Mshelia Saidu Paul B. Bokko Abdullahi Mohammed David N. Bukbuk Ephraim Igwenagu |
| author_facet | Abubakar Mshelia Saidu Paul B. Bokko Abdullahi Mohammed David N. Bukbuk Ephraim Igwenagu |
| author_sort | Abubakar Mshelia Saidu |
| collection | DOAJ |
| description | The utmost need for pragmatic combination of surgical sutures and local anaesthetic that would evoke minimal post-surgical stress response and allow uncomplicated healing is essential for successful surgeries. Fifteen Sahel goats were randomly allocated into three groups A, B and C to quantitatively assay (ELISA) serum cortisol profiles following rumenotomy, as markers of surgical stress. Diazepam at 0.2 mg/kg was administered intravenously to groups A and B with subsequent lidocaine HCl and bupivacaine inverted-L block respectively. Group C did not receive any treatment. Chromic catgut (CCG) and polyglycolic acid (PGA) sutures were used for rumen and abdominal muscles closure for groups A and B respectively and nylon for skin closure. Blood samples were taken at post anaesthetic induction (PAI) and post-surgery at 0, 5, 8, 24, 48 and 72 h. The Group A goats expressed serum cortisol that was significantly high 52.76 ± 6.12 ng/mL at 5 h post-surgery. At 8 h post-surgery serum cortisol for both groups A (72.53 ± 3.79 ng/mL) and B (61.59 ± 3.90 ng/mL) were at their peak. Serum cortisol levels compared to the baseline data were significantly different (P < 0.05) at 5, 24, and 48 h for the CCG goats. The serum cortisol levels at 72 h drastically decreased to 20.53 ± 8.74 ng/mL for groups A and 17.59 ± 2.45 ng/mL for group B and were not significantly different (p > 0.05). Cortisol responses unambiguously indicate that diazepam-bupivacaine induce less stress than Diazepam-lidocaine, hence a preferred anesthesia. Moreover, polyglycolic acid sutures are associated with less inflammatory reaction than chromic catgut. |
| first_indexed | 2024-12-18T19:42:24Z |
| format | Article |
| id | doaj.art-4698fc281ab2406fbea4a94ce92f8127 |
| institution | Directory Open Access Journal |
| issn | 2314-4599 |
| language | English |
| last_indexed | 2024-12-18T19:42:24Z |
| publishDate | 2016-06-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Veterinary Science and Medicine |
| spelling | doaj.art-4698fc281ab2406fbea4a94ce92f81272022-12-21T20:55:24ZengTaylor & Francis GroupInternational Journal of Veterinary Science and Medicine2314-45992016-06-0141232610.1016/j.ijvsm.2016.10.008Serum cortisol of Sahel goats following rumenotomy with assorted anaesthetics and suturesAbubakar Mshelia Saidu0Paul B. Bokko1Abdullahi Mohammed2David N. Bukbuk3Ephraim Igwenagu4Department of Veterinary Surgery and Radiology, University of Maiduguri, Maiduguri, Borno State, NigeriaDepartment of Veterinary Surgery and Radiology, University of Maiduguri, Maiduguri, Borno State, NigeriaDepartment of Veterinary Surgery and Radiology, University of Maiduguri, Maiduguri, Borno State, NigeriaDepartment of Microbiology, University of Maiduguri, Maiduguri, Borno State, NigeriaDepartment of Veterinary Pathology, University of Maiduguri, Maiduguri, Borno State, NigeriaThe utmost need for pragmatic combination of surgical sutures and local anaesthetic that would evoke minimal post-surgical stress response and allow uncomplicated healing is essential for successful surgeries. Fifteen Sahel goats were randomly allocated into three groups A, B and C to quantitatively assay (ELISA) serum cortisol profiles following rumenotomy, as markers of surgical stress. Diazepam at 0.2 mg/kg was administered intravenously to groups A and B with subsequent lidocaine HCl and bupivacaine inverted-L block respectively. Group C did not receive any treatment. Chromic catgut (CCG) and polyglycolic acid (PGA) sutures were used for rumen and abdominal muscles closure for groups A and B respectively and nylon for skin closure. Blood samples were taken at post anaesthetic induction (PAI) and post-surgery at 0, 5, 8, 24, 48 and 72 h. The Group A goats expressed serum cortisol that was significantly high 52.76 ± 6.12 ng/mL at 5 h post-surgery. At 8 h post-surgery serum cortisol for both groups A (72.53 ± 3.79 ng/mL) and B (61.59 ± 3.90 ng/mL) were at their peak. Serum cortisol levels compared to the baseline data were significantly different (P < 0.05) at 5, 24, and 48 h for the CCG goats. The serum cortisol levels at 72 h drastically decreased to 20.53 ± 8.74 ng/mL for groups A and 17.59 ± 2.45 ng/mL for group B and were not significantly different (p > 0.05). Cortisol responses unambiguously indicate that diazepam-bupivacaine induce less stress than Diazepam-lidocaine, hence a preferred anesthesia. Moreover, polyglycolic acid sutures are associated with less inflammatory reaction than chromic catgut.http://www.sciencedirect.com/science/article/pii/S2314459916300138Sahel goatCortisolRumenotomyPolyglycolic acidChromic catgutSuturesStress |
| spellingShingle | Abubakar Mshelia Saidu Paul B. Bokko Abdullahi Mohammed David N. Bukbuk Ephraim Igwenagu Serum cortisol of Sahel goats following rumenotomy with assorted anaesthetics and sutures International Journal of Veterinary Science and Medicine Sahel goat Cortisol Rumenotomy Polyglycolic acid Chromic catgut Sutures Stress |
| title | Serum cortisol of Sahel goats following rumenotomy with assorted anaesthetics and sutures |
| title_full | Serum cortisol of Sahel goats following rumenotomy with assorted anaesthetics and sutures |
| title_fullStr | Serum cortisol of Sahel goats following rumenotomy with assorted anaesthetics and sutures |
| title_full_unstemmed | Serum cortisol of Sahel goats following rumenotomy with assorted anaesthetics and sutures |
| title_short | Serum cortisol of Sahel goats following rumenotomy with assorted anaesthetics and sutures |
| title_sort | serum cortisol of sahel goats following rumenotomy with assorted anaesthetics and sutures |
| topic | Sahel goat Cortisol Rumenotomy Polyglycolic acid Chromic catgut Sutures Stress |
| url | http://www.sciencedirect.com/science/article/pii/S2314459916300138 |
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