Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol
Currently, an increasing number of diseases related to insulin resistance and obesity is an alarming problem worldwide. It is well-known that the above states can lead to the development of type 2 diabetes, hypertension, and cardiovascular diseases. An excessive amount of triacylglycerols (TAGs) in...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-03-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2020.00114/full |
| _version_ | 1818555461976195072 |
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| author | Patrycja Bielawiec Ewa Harasim-Symbor Adrian Chabowski |
| author_facet | Patrycja Bielawiec Ewa Harasim-Symbor Adrian Chabowski |
| author_sort | Patrycja Bielawiec |
| collection | DOAJ |
| description | Currently, an increasing number of diseases related to insulin resistance and obesity is an alarming problem worldwide. It is well-known that the above states can lead to the development of type 2 diabetes, hypertension, and cardiovascular diseases. An excessive amount of triacylglycerols (TAGs) in a diet also evokes adipocyte hyperplasia and subsequent accumulation of lipids in peripheral organs (liver, cardiac muscle). Therefore, new therapeutic methods are constantly sought for the prevention, treatment and alleviation of symptoms of the above mentioned diseases. Currently, much attention is paid to Cannabis derivatives—phytocannabinoids, which interact with the endocannabinoid system (ECS) constituents. Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are the most abundant compounds of Cannabis plants and their therapeutic application has been suggested. CBD is considered as a potential therapeutic agent due to its anti-inflammatory, anti-oxidant, anti-tumor, neuroprotective, and potential anti-obesity properties. Therefore, in this review, we especially highlight pharmacological properties of CBD as well as its impact on obesity in different tissues. |
| first_indexed | 2024-12-12T09:53:46Z |
| format | Article |
| id | doaj.art-469f70acf18e4277bb80cc2fc93c96f9 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-12T09:53:46Z |
| publishDate | 2020-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-469f70acf18e4277bb80cc2fc93c96f92022-12-22T00:28:11ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-03-011110.3389/fendo.2020.00114517425Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on CannabidiolPatrycja BielawiecEwa Harasim-SymborAdrian ChabowskiCurrently, an increasing number of diseases related to insulin resistance and obesity is an alarming problem worldwide. It is well-known that the above states can lead to the development of type 2 diabetes, hypertension, and cardiovascular diseases. An excessive amount of triacylglycerols (TAGs) in a diet also evokes adipocyte hyperplasia and subsequent accumulation of lipids in peripheral organs (liver, cardiac muscle). Therefore, new therapeutic methods are constantly sought for the prevention, treatment and alleviation of symptoms of the above mentioned diseases. Currently, much attention is paid to Cannabis derivatives—phytocannabinoids, which interact with the endocannabinoid system (ECS) constituents. Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are the most abundant compounds of Cannabis plants and their therapeutic application has been suggested. CBD is considered as a potential therapeutic agent due to its anti-inflammatory, anti-oxidant, anti-tumor, neuroprotective, and potential anti-obesity properties. Therefore, in this review, we especially highlight pharmacological properties of CBD as well as its impact on obesity in different tissues.https://www.frontiersin.org/article/10.3389/fendo.2020.00114/fullcannabidioldiabetesdrugsglucose metabolismobesityphytocannabinoids |
| spellingShingle | Patrycja Bielawiec Ewa Harasim-Symbor Adrian Chabowski Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol Frontiers in Endocrinology cannabidiol diabetes drugs glucose metabolism obesity phytocannabinoids |
| title | Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol |
| title_full | Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol |
| title_fullStr | Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol |
| title_full_unstemmed | Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol |
| title_short | Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol |
| title_sort | phytocannabinoids useful drugs for the treatment of obesity special focus on cannabidiol |
| topic | cannabidiol diabetes drugs glucose metabolism obesity phytocannabinoids |
| url | https://www.frontiersin.org/article/10.3389/fendo.2020.00114/full |
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