Quantification of Degradation Products Formed during Heat Sterilization of Glucose Solutions by LC-MS/MS: Impact of Autoclaving Temperature and Duration on Degradation

Quantification of Degradation Products Formed during Heat Sterilization of Glucose Solutions by LC-MS/MS: Impact of Autoclaving Temperature and Duration on Degradation

Heat sterilization of glucose solutions can lead to the formation of various glucose degradation products (GDPs) due to oxidation, hydrolysis, and dehydration. GDPs can have toxic effects after parenteral administration due to their high reactivity. In this study, the application of the F0 concept t...

Повний опис

Бібліографічні деталі
Автори: Sarah Leitzen, Matthias Vogel, Michael Steffens, Thomas Zapf, Christa Elisabeth Müller, Martin Brandl
Формат: Стаття
Мова:English
Опубліковано: MDPI AG 2021-11-01
Серія:Pharmaceuticals
Предмети:
F0 concept
steam sterilization
sterilization safety
glucose degradation products
α-dicarbonyl compounds
derivatization
Онлайн доступ:https://www.mdpi.com/1424-8247/14/11/1121

Інтернет

https://www.mdpi.com/1424-8247/14/11/1121

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