Chromatin Organization and Function in <i>Drosophila</i>
Eukaryotic genomes are packaged into high-order chromatin structures organized in discrete territories inside the cell nucleus, which is surrounded by the nuclear envelope acting as a barrier. This chromatin organization is complex and dynamic and, thus, determining the spatial and temporal distribu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/9/2362 |
| _version_ | 1797519890076139520 |
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| author | Palmira Llorens-Giralt Carlos Camilleri-Robles Montserrat Corominas Paula Climent-Cantó |
| author_facet | Palmira Llorens-Giralt Carlos Camilleri-Robles Montserrat Corominas Paula Climent-Cantó |
| author_sort | Palmira Llorens-Giralt |
| collection | DOAJ |
| description | Eukaryotic genomes are packaged into high-order chromatin structures organized in discrete territories inside the cell nucleus, which is surrounded by the nuclear envelope acting as a barrier. This chromatin organization is complex and dynamic and, thus, determining the spatial and temporal distribution and folding of chromosomes within the nucleus is critical for understanding the role of chromatin topology in genome function. Primarily focusing on the regulation of gene expression, we review here how the genome of <i>Drosophila melanogaster</i> is organized into the cell nucleus, from small scale histone–DNA interactions to chromosome and lamina interactions in the nuclear space. |
| first_indexed | 2024-03-10T07:49:11Z |
| format | Article |
| id | doaj.art-46a0ac7005204b99810896bd8e4924c6 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T07:49:11Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-46a0ac7005204b99810896bd8e4924c62023-11-22T12:24:54ZengMDPI AGCells2073-44092021-09-01109236210.3390/cells10092362Chromatin Organization and Function in <i>Drosophila</i>Palmira Llorens-Giralt0Carlos Camilleri-Robles1Montserrat Corominas2Paula Climent-Cantó3Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia and Insitut de Biomedicina (IBUB), Universitat de Barcelona, 08028 Barcelona, Catalonia, SpainDepartament de Genètica, Microbiologia i Estadística, Facultat de Biologia and Insitut de Biomedicina (IBUB), Universitat de Barcelona, 08028 Barcelona, Catalonia, SpainDepartament de Genètica, Microbiologia i Estadística, Facultat de Biologia and Insitut de Biomedicina (IBUB), Universitat de Barcelona, 08028 Barcelona, Catalonia, SpainDepartament de Genètica, Microbiologia i Estadística, Facultat de Biologia and Insitut de Biomedicina (IBUB), Universitat de Barcelona, 08028 Barcelona, Catalonia, SpainEukaryotic genomes are packaged into high-order chromatin structures organized in discrete territories inside the cell nucleus, which is surrounded by the nuclear envelope acting as a barrier. This chromatin organization is complex and dynamic and, thus, determining the spatial and temporal distribution and folding of chromosomes within the nucleus is critical for understanding the role of chromatin topology in genome function. Primarily focusing on the regulation of gene expression, we review here how the genome of <i>Drosophila melanogaster</i> is organized into the cell nucleus, from small scale histone–DNA interactions to chromosome and lamina interactions in the nuclear space.https://www.mdpi.com/2073-4409/10/9/2362chromatin compositionchromatin organizationgene regulation3D genome structurenuclear architecture |
| spellingShingle | Palmira Llorens-Giralt Carlos Camilleri-Robles Montserrat Corominas Paula Climent-Cantó Chromatin Organization and Function in <i>Drosophila</i> Cells chromatin composition chromatin organization gene regulation 3D genome structure nuclear architecture |
| title | Chromatin Organization and Function in <i>Drosophila</i> |
| title_full | Chromatin Organization and Function in <i>Drosophila</i> |
| title_fullStr | Chromatin Organization and Function in <i>Drosophila</i> |
| title_full_unstemmed | Chromatin Organization and Function in <i>Drosophila</i> |
| title_short | Chromatin Organization and Function in <i>Drosophila</i> |
| title_sort | chromatin organization and function in i drosophila i |
| topic | chromatin composition chromatin organization gene regulation 3D genome structure nuclear architecture |
| url | https://www.mdpi.com/2073-4409/10/9/2362 |
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