<i>Callyspongia</i> spp.: Secondary Metabolites, Pharmacological Activities, and Mechanisms
One of the most widespread biotas in the sea is the sponge. <i>Callyspongia</i> is a sponge genus found in the seas, making it easily available. In this review, the pharmacological activity and mechanism of action of the secondary metabolites of <i>Callyspongia</i> spp. are a...
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MDPI AG
2023-02-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/2/217 |
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| author | Yuni Elsa Hadisaputri Annida Adha Nurhaniefah Sendi Sukmara Ade Zuhrotun Rini Hendriani Iyan Sopyan |
| author_facet | Yuni Elsa Hadisaputri Annida Adha Nurhaniefah Sendi Sukmara Ade Zuhrotun Rini Hendriani Iyan Sopyan |
| author_sort | Yuni Elsa Hadisaputri |
| collection | DOAJ |
| description | One of the most widespread biotas in the sea is the sponge. <i>Callyspongia</i> is a sponge genus found in the seas, making it easily available. In this review, the pharmacological activity and mechanism of action of the secondary metabolites of <i>Callyspongia</i> spp. are addressed, which may lead to the development of new drugs and targeted therapeutic approaches. Several scientific databases, such as Google Scholar, PubMed, ResearchGate, Science Direct, Springer Link, and Wiley Online Library, were mined to obtain relevant information. In the 41 articles reviewed, <i>Callyspongia</i> spp. was reported to possess pharmacological activities such as cytotoxicity against cancer cell lines (36%), antifungal (10%), anti-inflammatory (10%), immunomodulatory (10%), antidiabetic and antiobesity (6%), antimicrobial (8%), antioxidant (4%), antineurodegenerative (4%), antihypercholesterolemic (2%), antihypertensive (2%), antiparasitic (2%), antiallergic (2%), antiviral (2%), antiosteoporotic (2%), and antituberculosis (2%) activities. Of these, the antioxidant, antituberculosis, and anti-inflammatory activities of <i>Callyspongia</i> extract were weaker compared with that of the control drugs; however, other activities, particularly cytotoxicity, show promise, and the compounds responsible may be developed into new drugs. |
| first_indexed | 2024-03-11T08:26:06Z |
| format | Article |
| id | doaj.art-46a1f278eddb4f7cbebe6ac2a3ee9943 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T08:26:06Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-46a1f278eddb4f7cbebe6ac2a3ee99432023-11-16T22:04:31ZengMDPI AGMetabolites2218-19892023-02-0113221710.3390/metabo13020217<i>Callyspongia</i> spp.: Secondary Metabolites, Pharmacological Activities, and MechanismsYuni Elsa Hadisaputri0Annida Adha Nurhaniefah1Sendi Sukmara2Ade Zuhrotun3Rini Hendriani4Iyan Sopyan5Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor 45363, IndonesiaDepartment of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor 45363, IndonesiaDepartment of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor 45363, IndonesiaDepartment of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor 45363, IndonesiaDepartment of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor 45363, IndonesiaDepartement of Pharmaceutics and Technology of Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor 45363, IndonesiaOne of the most widespread biotas in the sea is the sponge. <i>Callyspongia</i> is a sponge genus found in the seas, making it easily available. In this review, the pharmacological activity and mechanism of action of the secondary metabolites of <i>Callyspongia</i> spp. are addressed, which may lead to the development of new drugs and targeted therapeutic approaches. Several scientific databases, such as Google Scholar, PubMed, ResearchGate, Science Direct, Springer Link, and Wiley Online Library, were mined to obtain relevant information. In the 41 articles reviewed, <i>Callyspongia</i> spp. was reported to possess pharmacological activities such as cytotoxicity against cancer cell lines (36%), antifungal (10%), anti-inflammatory (10%), immunomodulatory (10%), antidiabetic and antiobesity (6%), antimicrobial (8%), antioxidant (4%), antineurodegenerative (4%), antihypercholesterolemic (2%), antihypertensive (2%), antiparasitic (2%), antiallergic (2%), antiviral (2%), antiosteoporotic (2%), and antituberculosis (2%) activities. Of these, the antioxidant, antituberculosis, and anti-inflammatory activities of <i>Callyspongia</i> extract were weaker compared with that of the control drugs; however, other activities, particularly cytotoxicity, show promise, and the compounds responsible may be developed into new drugs.https://www.mdpi.com/2218-1989/13/2/217<i>Callyspongia</i> spp.secondary metabolitepharmacological activitymechanismcytotoxic |
| spellingShingle | Yuni Elsa Hadisaputri Annida Adha Nurhaniefah Sendi Sukmara Ade Zuhrotun Rini Hendriani Iyan Sopyan <i>Callyspongia</i> spp.: Secondary Metabolites, Pharmacological Activities, and Mechanisms Metabolites <i>Callyspongia</i> spp. secondary metabolite pharmacological activity mechanism cytotoxic |
| title | <i>Callyspongia</i> spp.: Secondary Metabolites, Pharmacological Activities, and Mechanisms |
| title_full | <i>Callyspongia</i> spp.: Secondary Metabolites, Pharmacological Activities, and Mechanisms |
| title_fullStr | <i>Callyspongia</i> spp.: Secondary Metabolites, Pharmacological Activities, and Mechanisms |
| title_full_unstemmed | <i>Callyspongia</i> spp.: Secondary Metabolites, Pharmacological Activities, and Mechanisms |
| title_short | <i>Callyspongia</i> spp.: Secondary Metabolites, Pharmacological Activities, and Mechanisms |
| title_sort | i callyspongia i spp secondary metabolites pharmacological activities and mechanisms |
| topic | <i>Callyspongia</i> spp. secondary metabolite pharmacological activity mechanism cytotoxic |
| url | https://www.mdpi.com/2218-1989/13/2/217 |
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