Determination and Pharmacokinetic Study of Gentiopicroside, Geniposide, Baicalin, and Swertiamarin in Chinese Herbal Formulae after Oral Administration in Rats by LC-MS/MS

Determination and Pharmacokinetic Study of Gentiopicroside, Geniposide, Baicalin, and Swertiamarin in Chinese Herbal Formulae after Oral Administration in Rats by LC-MS/MS

A sensitive and efficient liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous determination of gentiopicroside, geniposide, baicalin, and swertiamarin in rat plasma. To avoid the stress caused by restraint or anesthesia, a freely moving rat model was...

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Bibliographic Details
Main Authors: Chia-Ming Lu, Lie-Chwen Lin, Tung-Hu Tsai
Format: Article
Language:English
Published: MDPI AG 2014-12-01
Series:Molecules
Subjects:
phytochemical analysis
LC-MS/MS
herbal medicine
pharmacokinetics
traditional Chinese medicine
Online Access:http://www.mdpi.com/1420-3049/19/12/21560

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