TRIM5α selectively binds a restriction-sensitive retroviral capsid
<p>Abstract</p> <p>TRIM5 is a potent retrovirus inhibitor that targets viruses bearing particular capsid (CA) residues. In most primate species, retroviral restriction requires the C-terminal SPRY domain unique to the α-isoform of TRIM5, but the mechanism by which susceptible virus...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2005-06-01
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| Series: | Retrovirology |
| Online Access: | http://www.retrovirology.com/content/2/1/40 |
| _version_ | 1818807217849106432 |
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| author | Luban Jeremy Sebastian Sarah |
| author_facet | Luban Jeremy Sebastian Sarah |
| author_sort | Luban Jeremy |
| collection | DOAJ |
| description | <p>Abstract</p> <p>TRIM5 is a potent retrovirus inhibitor that targets viruses bearing particular capsid (CA) residues. In most primate species, retroviral restriction requires the C-terminal SPRY domain unique to the α-isoform of TRIM5, but the mechanism by which susceptible viruses are recognized and targeted for restriction is unknown. Here we show that TRIM5α binds retroviral CA from detergent-stripped virions in a SPRY-dependent manner with sufficient discrimination to account for the exquisite specificity of restriction.</p> |
| first_indexed | 2024-12-18T19:22:10Z |
| format | Article |
| id | doaj.art-46a3bffb027a4bf98c1cb38853974c48 |
| institution | Directory Open Access Journal |
| issn | 1742-4690 |
| language | English |
| last_indexed | 2024-12-18T19:22:10Z |
| publishDate | 2005-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Retrovirology |
| spelling | doaj.art-46a3bffb027a4bf98c1cb38853974c482022-12-21T20:55:58ZengBMCRetrovirology1742-46902005-06-01214010.1186/1742-4690-2-40TRIM5α selectively binds a restriction-sensitive retroviral capsidLuban JeremySebastian Sarah<p>Abstract</p> <p>TRIM5 is a potent retrovirus inhibitor that targets viruses bearing particular capsid (CA) residues. In most primate species, retroviral restriction requires the C-terminal SPRY domain unique to the α-isoform of TRIM5, but the mechanism by which susceptible viruses are recognized and targeted for restriction is unknown. Here we show that TRIM5α binds retroviral CA from detergent-stripped virions in a SPRY-dependent manner with sufficient discrimination to account for the exquisite specificity of restriction.</p>http://www.retrovirology.com/content/2/1/40 |
| spellingShingle | Luban Jeremy Sebastian Sarah TRIM5α selectively binds a restriction-sensitive retroviral capsid Retrovirology |
| title | TRIM5α selectively binds a restriction-sensitive retroviral capsid |
| title_full | TRIM5α selectively binds a restriction-sensitive retroviral capsid |
| title_fullStr | TRIM5α selectively binds a restriction-sensitive retroviral capsid |
| title_full_unstemmed | TRIM5α selectively binds a restriction-sensitive retroviral capsid |
| title_short | TRIM5α selectively binds a restriction-sensitive retroviral capsid |
| title_sort | trim5α selectively binds a restriction sensitive retroviral capsid |
| url | http://www.retrovirology.com/content/2/1/40 |
| work_keys_str_mv | AT lubanjeremy trim5aselectivelybindsarestrictionsensitiveretroviralcapsid AT sebastiansarah trim5aselectivelybindsarestrictionsensitiveretroviralcapsid |