A Guide to Polysaccharide-Based Hydrogel Bioinks for 3D Bioprinting Applications
Three-dimensional (3D) bioprinting is an innovative technology in the biomedical field, allowing the fabrication of living constructs through an approach of layer-by-layer deposition of cell-laden inks, the so-called bioinks. An ideal bioink should possess proper mechanical, rheological, chemical, a...
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/12/6564 |
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| author | Maria C. Teixeira Nicole S. Lameirinhas João P. F. Carvalho Armando J. D. Silvestre Carla Vilela Carmen S. R. Freire |
| author_facet | Maria C. Teixeira Nicole S. Lameirinhas João P. F. Carvalho Armando J. D. Silvestre Carla Vilela Carmen S. R. Freire |
| author_sort | Maria C. Teixeira |
| collection | DOAJ |
| description | Three-dimensional (3D) bioprinting is an innovative technology in the biomedical field, allowing the fabrication of living constructs through an approach of layer-by-layer deposition of cell-laden inks, the so-called bioinks. An ideal bioink should possess proper mechanical, rheological, chemical, and biological characteristics to ensure high cell viability and the production of tissue constructs with dimensional stability and shape fidelity. Among the several types of bioinks, hydrogels are extremely appealing as they have many similarities with the extracellular matrix, providing a highly hydrated environment for cell proliferation and tunability in terms of mechanical and rheological properties. Hydrogels derived from natural polymers, and polysaccharides, in particular, are an excellent platform to mimic the extracellular matrix, given their low cytotoxicity, high hydrophilicity, and diversity of structures. In fact, polysaccharide-based hydrogels are trendy materials for 3D bioprinting since they are abundant and combine adequate physicochemical and biomimetic features for the development of novel bioinks. Thus, this review portrays the most relevant advances in polysaccharide-based hydrogel bioinks for 3D bioprinting, focusing on the last five years, with emphasis on their properties, advantages, and limitations, considering polysaccharide families classified according to their source, namely from seaweed, higher plants, microbial, and animal (particularly crustaceans) origin. |
| first_indexed | 2024-03-09T23:34:58Z |
| format | Article |
| id | doaj.art-46a50c296a464921aef16a58ed9fa778 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:34:58Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-46a50c296a464921aef16a58ed9fa7782023-11-23T17:02:54ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012312656410.3390/ijms23126564A Guide to Polysaccharide-Based Hydrogel Bioinks for 3D Bioprinting ApplicationsMaria C. Teixeira0Nicole S. Lameirinhas1João P. F. Carvalho2Armando J. D. Silvestre3Carla Vilela4Carmen S. R. Freire5CICECO—Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, PortugalCICECO—Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, PortugalCICECO—Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, PortugalCICECO—Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, PortugalCICECO—Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, PortugalCICECO—Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, PortugalThree-dimensional (3D) bioprinting is an innovative technology in the biomedical field, allowing the fabrication of living constructs through an approach of layer-by-layer deposition of cell-laden inks, the so-called bioinks. An ideal bioink should possess proper mechanical, rheological, chemical, and biological characteristics to ensure high cell viability and the production of tissue constructs with dimensional stability and shape fidelity. Among the several types of bioinks, hydrogels are extremely appealing as they have many similarities with the extracellular matrix, providing a highly hydrated environment for cell proliferation and tunability in terms of mechanical and rheological properties. Hydrogels derived from natural polymers, and polysaccharides, in particular, are an excellent platform to mimic the extracellular matrix, given their low cytotoxicity, high hydrophilicity, and diversity of structures. In fact, polysaccharide-based hydrogels are trendy materials for 3D bioprinting since they are abundant and combine adequate physicochemical and biomimetic features for the development of novel bioinks. Thus, this review portrays the most relevant advances in polysaccharide-based hydrogel bioinks for 3D bioprinting, focusing on the last five years, with emphasis on their properties, advantages, and limitations, considering polysaccharide families classified according to their source, namely from seaweed, higher plants, microbial, and animal (particularly crustaceans) origin.https://www.mdpi.com/1422-0067/23/12/65643D bioprintingbioinkscell-laden constructshydrogelspolysaccharides |
| spellingShingle | Maria C. Teixeira Nicole S. Lameirinhas João P. F. Carvalho Armando J. D. Silvestre Carla Vilela Carmen S. R. Freire A Guide to Polysaccharide-Based Hydrogel Bioinks for 3D Bioprinting Applications International Journal of Molecular Sciences 3D bioprinting bioinks cell-laden constructs hydrogels polysaccharides |
| title | A Guide to Polysaccharide-Based Hydrogel Bioinks for 3D Bioprinting Applications |
| title_full | A Guide to Polysaccharide-Based Hydrogel Bioinks for 3D Bioprinting Applications |
| title_fullStr | A Guide to Polysaccharide-Based Hydrogel Bioinks for 3D Bioprinting Applications |
| title_full_unstemmed | A Guide to Polysaccharide-Based Hydrogel Bioinks for 3D Bioprinting Applications |
| title_short | A Guide to Polysaccharide-Based Hydrogel Bioinks for 3D Bioprinting Applications |
| title_sort | guide to polysaccharide based hydrogel bioinks for 3d bioprinting applications |
| topic | 3D bioprinting bioinks cell-laden constructs hydrogels polysaccharides |
| url | https://www.mdpi.com/1422-0067/23/12/6564 |
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