Distinct Cerebrospinal Fluid Lipid Signature in Patients with Subarachnoid Hemorrhage-Induced Hydrocephalus
Patients with subarachnoid hemorrhage (SAH) may develop posthemorrhagic hydrocephalus (PHH), which is treated with surgical cerebrospinal fluid (CSF) diversion. This diversion is associated with risk of infection and shunt failure. Biomarkers for PHH etiology, CSF dynamics disturbances, and potentia...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/9/2360 |
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| author | Trine L. Toft-Bertelsen Søren Norge Andreassen Nina Rostgaard Markus Harboe Olsen Nicolas H. Norager Tenna Capion Marianne Juhler Nanna MacAulay |
| author_facet | Trine L. Toft-Bertelsen Søren Norge Andreassen Nina Rostgaard Markus Harboe Olsen Nicolas H. Norager Tenna Capion Marianne Juhler Nanna MacAulay |
| author_sort | Trine L. Toft-Bertelsen |
| collection | DOAJ |
| description | Patients with subarachnoid hemorrhage (SAH) may develop posthemorrhagic hydrocephalus (PHH), which is treated with surgical cerebrospinal fluid (CSF) diversion. This diversion is associated with risk of infection and shunt failure. Biomarkers for PHH etiology, CSF dynamics disturbances, and potentially subsequent shunt dependency are therefore in demand. With the recent demonstration of lipid-mediated CSF hypersecretion contributing to PHH, exploration of the CSF lipid signature in relation to brain pathology is of interest. Despite being a relatively new addition to the omic’s landscape, lipidomics are increasingly recognized as a tool for biomarker identification, as they provide a comprehensive overview of lipid profiles in biological systems. We here employ an untargeted mass spectroscopy-based platform and reveal the complete lipid profile of cisternal CSF from healthy control subjects and demonstrate its bimodal fluctuation with age. Various classes of lipids, in addition to select individual lipids, were elevated in the ventricular CSF obtained from patients with SAH during placement of an external ventricular drain. The lipidomic signature of the CSF in the patients with SAH suggests dysregulation of the lipids in the CSF in this patient group. Our data thereby reveal possible biomarkers present in a brain pathology with a hemorrhagic event, some of which could be potential future biomarkers for hypersecretion contributing to ventriculomegaly and thus pharmacological targets for pathologies involving disturbed CSF dynamics. |
| first_indexed | 2024-03-10T23:01:17Z |
| format | Article |
| id | doaj.art-46a5128b67b64db3860c84767a8557d2 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T23:01:17Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-46a5128b67b64db3860c84767a8557d22023-11-19T09:40:11ZengMDPI AGBiomedicines2227-90592023-08-01119236010.3390/biomedicines11092360Distinct Cerebrospinal Fluid Lipid Signature in Patients with Subarachnoid Hemorrhage-Induced HydrocephalusTrine L. Toft-Bertelsen0Søren Norge Andreassen1Nina Rostgaard2Markus Harboe Olsen3Nicolas H. Norager4Tenna Capion5Marianne Juhler6Nanna MacAulay7Department of Neuroscience, University of Copenhagen, 2200 Copenhagen, DenmarkDepartment of Neuroscience, University of Copenhagen, 2200 Copenhagen, DenmarkDepartment of Neurosurgery, Neuroscience Centre, Copenhagen University Hospital—Rigshospitalet, 2100 Copenhagen, DenmarkDepartment of Neuroanaesthesiology, Neuroscience Centre, Copenhagen University Hospital—Rigshospitalet, 2100 Copenhagen, DenmarkDepartment of Neurosurgery, Neuroscience Centre, Copenhagen University Hospital—Rigshospitalet, 2100 Copenhagen, DenmarkDepartment of Neurosurgery, Neuroscience Centre, Copenhagen University Hospital—Rigshospitalet, 2100 Copenhagen, DenmarkDepartment of Neurosurgery, Neuroscience Centre, Copenhagen University Hospital—Rigshospitalet, 2100 Copenhagen, DenmarkDepartment of Neuroscience, University of Copenhagen, 2200 Copenhagen, DenmarkPatients with subarachnoid hemorrhage (SAH) may develop posthemorrhagic hydrocephalus (PHH), which is treated with surgical cerebrospinal fluid (CSF) diversion. This diversion is associated with risk of infection and shunt failure. Biomarkers for PHH etiology, CSF dynamics disturbances, and potentially subsequent shunt dependency are therefore in demand. With the recent demonstration of lipid-mediated CSF hypersecretion contributing to PHH, exploration of the CSF lipid signature in relation to brain pathology is of interest. Despite being a relatively new addition to the omic’s landscape, lipidomics are increasingly recognized as a tool for biomarker identification, as they provide a comprehensive overview of lipid profiles in biological systems. We here employ an untargeted mass spectroscopy-based platform and reveal the complete lipid profile of cisternal CSF from healthy control subjects and demonstrate its bimodal fluctuation with age. Various classes of lipids, in addition to select individual lipids, were elevated in the ventricular CSF obtained from patients with SAH during placement of an external ventricular drain. The lipidomic signature of the CSF in the patients with SAH suggests dysregulation of the lipids in the CSF in this patient group. Our data thereby reveal possible biomarkers present in a brain pathology with a hemorrhagic event, some of which could be potential future biomarkers for hypersecretion contributing to ventriculomegaly and thus pharmacological targets for pathologies involving disturbed CSF dynamics.https://www.mdpi.com/2227-9059/11/9/2360cerebrospinal fluidlipidomicsmass spectrometryposthemorrhagic hydrocephalusSAH |
| spellingShingle | Trine L. Toft-Bertelsen Søren Norge Andreassen Nina Rostgaard Markus Harboe Olsen Nicolas H. Norager Tenna Capion Marianne Juhler Nanna MacAulay Distinct Cerebrospinal Fluid Lipid Signature in Patients with Subarachnoid Hemorrhage-Induced Hydrocephalus Biomedicines cerebrospinal fluid lipidomics mass spectrometry posthemorrhagic hydrocephalus SAH |
| title | Distinct Cerebrospinal Fluid Lipid Signature in Patients with Subarachnoid Hemorrhage-Induced Hydrocephalus |
| title_full | Distinct Cerebrospinal Fluid Lipid Signature in Patients with Subarachnoid Hemorrhage-Induced Hydrocephalus |
| title_fullStr | Distinct Cerebrospinal Fluid Lipid Signature in Patients with Subarachnoid Hemorrhage-Induced Hydrocephalus |
| title_full_unstemmed | Distinct Cerebrospinal Fluid Lipid Signature in Patients with Subarachnoid Hemorrhage-Induced Hydrocephalus |
| title_short | Distinct Cerebrospinal Fluid Lipid Signature in Patients with Subarachnoid Hemorrhage-Induced Hydrocephalus |
| title_sort | distinct cerebrospinal fluid lipid signature in patients with subarachnoid hemorrhage induced hydrocephalus |
| topic | cerebrospinal fluid lipidomics mass spectrometry posthemorrhagic hydrocephalus SAH |
| url | https://www.mdpi.com/2227-9059/11/9/2360 |
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