A narrative review on the role of genetics in children with acute recurrent pancreatitis and chronic pancreatitis
ABSTRACT The incidence of pancreatitis in children has increased over the past two decades. With advances in molecular biological techniques and clinical research, genetic variations have emerged as a pivotal etiological factor in pediatric pancreatitis. This review aims to summarize recent clinical...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-12-01
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| Series: | Pediatric Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ped4.12404 |
| _version_ | 1797422293280882688 |
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| author | Bo Yu Yi Yu Xinqiong Wang Chundi Xu Yuan Xiao |
| author_facet | Bo Yu Yi Yu Xinqiong Wang Chundi Xu Yuan Xiao |
| author_sort | Bo Yu |
| collection | DOAJ |
| description | ABSTRACT The incidence of pancreatitis in children has increased over the past two decades. With advances in molecular biological techniques and clinical research, genetic variations have emerged as a pivotal etiological factor in pediatric pancreatitis. This review aims to summarize recent clinical research advancements in understanding pediatric pancreatitis caused by various gene mutations. As of the year 2020, researchers had identified 12 genes implicated in the pathogenesis of pancreatitis. These genes primarily contributed to the development of pancreatitis through three mechanisms. Pancreatitis resulting from these gene mutations exhibits several distinct characteristics, including early onset, a heightened risk of developing pancreatic duct stones, rapid disease progression, and a significantly increased risk of pancreatic endocrine and exocrine dysfunction, as well as pancreatic cancer in the future. Genetic sequencing is recommended for children with pancreatitis based on six indications. The sequencing not only assists in the clinical diagnosis but also enhances our understanding of the pathophysiology of pancreatitis. |
| first_indexed | 2024-03-09T07:30:05Z |
| format | Article |
| id | doaj.art-46aa10833a254cd1836f9061251b6d1c |
| institution | Directory Open Access Journal |
| issn | 2574-2272 |
| language | English |
| last_indexed | 2024-03-09T07:30:05Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pediatric Investigation |
| spelling | doaj.art-46aa10833a254cd1836f9061251b6d1c2023-12-03T06:24:55ZengWileyPediatric Investigation2574-22722023-12-017426827610.1002/ped4.12404A narrative review on the role of genetics in children with acute recurrent pancreatitis and chronic pancreatitisBo Yu0Yi Yu1Xinqiong Wang2Chundi Xu3Yuan Xiao4School of Clinical Medicine Shanghai University of Medicine and Health Sciences Shanghai ChinaPediatric Department Ruijin Hospital School of Medicine Shanghai Jiao Tong University Shanghai ChinaPediatric Department Ruijin Hospital School of Medicine Shanghai Jiao Tong University Shanghai ChinaPediatric Department Ruijin Hospital School of Medicine Shanghai Jiao Tong University Shanghai ChinaPediatric Department Ruijin Hospital School of Medicine Shanghai Jiao Tong University Shanghai ChinaABSTRACT The incidence of pancreatitis in children has increased over the past two decades. With advances in molecular biological techniques and clinical research, genetic variations have emerged as a pivotal etiological factor in pediatric pancreatitis. This review aims to summarize recent clinical research advancements in understanding pediatric pancreatitis caused by various gene mutations. As of the year 2020, researchers had identified 12 genes implicated in the pathogenesis of pancreatitis. These genes primarily contributed to the development of pancreatitis through three mechanisms. Pancreatitis resulting from these gene mutations exhibits several distinct characteristics, including early onset, a heightened risk of developing pancreatic duct stones, rapid disease progression, and a significantly increased risk of pancreatic endocrine and exocrine dysfunction, as well as pancreatic cancer in the future. Genetic sequencing is recommended for children with pancreatitis based on six indications. The sequencing not only assists in the clinical diagnosis but also enhances our understanding of the pathophysiology of pancreatitis.https://doi.org/10.1002/ped4.12404PancreatitisPediatricGeneSequencing |
| spellingShingle | Bo Yu Yi Yu Xinqiong Wang Chundi Xu Yuan Xiao A narrative review on the role of genetics in children with acute recurrent pancreatitis and chronic pancreatitis Pediatric Investigation Pancreatitis Pediatric Gene Sequencing |
| title | A narrative review on the role of genetics in children with acute recurrent pancreatitis and chronic pancreatitis |
| title_full | A narrative review on the role of genetics in children with acute recurrent pancreatitis and chronic pancreatitis |
| title_fullStr | A narrative review on the role of genetics in children with acute recurrent pancreatitis and chronic pancreatitis |
| title_full_unstemmed | A narrative review on the role of genetics in children with acute recurrent pancreatitis and chronic pancreatitis |
| title_short | A narrative review on the role of genetics in children with acute recurrent pancreatitis and chronic pancreatitis |
| title_sort | narrative review on the role of genetics in children with acute recurrent pancreatitis and chronic pancreatitis |
| topic | Pancreatitis Pediatric Gene Sequencing |
| url | https://doi.org/10.1002/ped4.12404 |
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