The role of platelet-related parameters for the prediction of NAFLD in OSAHS patients
Abstract Purpose As the detection of non-alcoholic fatty liver disease (NAFLD) is imperative for the prevention of its complications, we aimed to explore the predictive value of platelet to lymphocyte count ratio (PLR) and white blood cell count to mean platelet volume ratio (WBC/MPV) in relation to...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-022-02291-6 |
| _version_ | 1797977591330635776 |
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| author | Menglan Chen Biying Wang Jiefeng Huang Jianming Zhao Jia Chen Gongping Chen |
| author_facet | Menglan Chen Biying Wang Jiefeng Huang Jianming Zhao Jia Chen Gongping Chen |
| author_sort | Menglan Chen |
| collection | DOAJ |
| description | Abstract Purpose As the detection of non-alcoholic fatty liver disease (NAFLD) is imperative for the prevention of its complications, we aimed to explore the predictive value of platelet to lymphocyte count ratio (PLR) and white blood cell count to mean platelet volume ratio (WBC/MPV) in relation to the occurrence of NAFLD among patients with obstructive sleep apnea–hypopnea syndrome (OSAHS). Methods This was a cross-sectional study consisting of 351 patients with OSAHS (279 with and 72 without NAFLD). The logistic regression analysis was performed to estimate associations between PLR, WBC/MPV, and NAFLD. Finally, the receiver operating characteristic curve (ROC curve) was used to analyze the efficacy of PLR and WBC/MPV in NAFLD prediction. Results Compared to the OSAHS-only group, there was a rising trend in AHI and TS90% in the OSAHS + NAFLD group. And the logistic regression analysis identified average oxygen saturation (MaSO2), WBC/MPV and PLR as predicted factors (odds ratio [OR] = 1.134, P = 0.031; OR = 7.559, P = 0.018, OR = 0.980, P < 0.001, respectively) for NAFLD in OSAHS patients. Moreover, compared with WBC/MPV, PLR, FLI, and APRI, a combination of WBC/MPV and PLR presented the largest AUC for the detection of NAFLD in BMI < 28 kg/m2 (0.753, 95% CI 0.684–0.822), and in age ≥ 60 years subgroup (0.786, 95% CI 0.692–0.880) in ROC analysis. Meanwhile, a combination of WBC/MPV and PLR presented the second largest AUC for the detection of NAFLD in all subjects (0.743, 95% CI 0.708–0.831), as well as in the age < 60 years subgroup (0.729, 95% CI 0.652–0.806), only ranked after FLI, suggesting the combination of WBC/MPV and PLR has a good predictive value for NAFLD in OSAHS patients. Conclusion We confirmed that the levels of WBC/MPV, PLR, and MaSO2 were closely related to the occurrence of NAFLD among OSAHS patients. Furthermore, our results highlighted the clinical combination of WBC/MPV and PLR levels could act as a simple and effective biomarker for screening NAFLD in patients with OSAHS. |
| first_indexed | 2024-04-11T05:09:31Z |
| format | Article |
| id | doaj.art-46ab85ce09f140039767b34eb5ca25f8 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-04-11T05:09:31Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-46ab85ce09f140039767b34eb5ca25f82022-12-25T12:04:09ZengBMCBMC Pulmonary Medicine1471-24662022-12-0122111210.1186/s12890-022-02291-6The role of platelet-related parameters for the prediction of NAFLD in OSAHS patientsMenglan Chen0Biying Wang1Jiefeng Huang2Jianming Zhao3Jia Chen4Gongping Chen5Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Fujian Medical UniversityDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Fujian Medical UniversityDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Fujian Medical UniversityDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Fujian Medical UniversityDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Fujian Medical UniversityDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Fujian Medical UniversityAbstract Purpose As the detection of non-alcoholic fatty liver disease (NAFLD) is imperative for the prevention of its complications, we aimed to explore the predictive value of platelet to lymphocyte count ratio (PLR) and white blood cell count to mean platelet volume ratio (WBC/MPV) in relation to the occurrence of NAFLD among patients with obstructive sleep apnea–hypopnea syndrome (OSAHS). Methods This was a cross-sectional study consisting of 351 patients with OSAHS (279 with and 72 without NAFLD). The logistic regression analysis was performed to estimate associations between PLR, WBC/MPV, and NAFLD. Finally, the receiver operating characteristic curve (ROC curve) was used to analyze the efficacy of PLR and WBC/MPV in NAFLD prediction. Results Compared to the OSAHS-only group, there was a rising trend in AHI and TS90% in the OSAHS + NAFLD group. And the logistic regression analysis identified average oxygen saturation (MaSO2), WBC/MPV and PLR as predicted factors (odds ratio [OR] = 1.134, P = 0.031; OR = 7.559, P = 0.018, OR = 0.980, P < 0.001, respectively) for NAFLD in OSAHS patients. Moreover, compared with WBC/MPV, PLR, FLI, and APRI, a combination of WBC/MPV and PLR presented the largest AUC for the detection of NAFLD in BMI < 28 kg/m2 (0.753, 95% CI 0.684–0.822), and in age ≥ 60 years subgroup (0.786, 95% CI 0.692–0.880) in ROC analysis. Meanwhile, a combination of WBC/MPV and PLR presented the second largest AUC for the detection of NAFLD in all subjects (0.743, 95% CI 0.708–0.831), as well as in the age < 60 years subgroup (0.729, 95% CI 0.652–0.806), only ranked after FLI, suggesting the combination of WBC/MPV and PLR has a good predictive value for NAFLD in OSAHS patients. Conclusion We confirmed that the levels of WBC/MPV, PLR, and MaSO2 were closely related to the occurrence of NAFLD among OSAHS patients. Furthermore, our results highlighted the clinical combination of WBC/MPV and PLR levels could act as a simple and effective biomarker for screening NAFLD in patients with OSAHS.https://doi.org/10.1186/s12890-022-02291-6Obstructive sleep apnea–hypopnea syndromeNon-alcoholic fatty liver diseasePlatelet to lymphocyte count ratioWhite blood cell count to mean platelet volume ratio |
| spellingShingle | Menglan Chen Biying Wang Jiefeng Huang Jianming Zhao Jia Chen Gongping Chen The role of platelet-related parameters for the prediction of NAFLD in OSAHS patients BMC Pulmonary Medicine Obstructive sleep apnea–hypopnea syndrome Non-alcoholic fatty liver disease Platelet to lymphocyte count ratio White blood cell count to mean platelet volume ratio |
| title | The role of platelet-related parameters for the prediction of NAFLD in OSAHS patients |
| title_full | The role of platelet-related parameters for the prediction of NAFLD in OSAHS patients |
| title_fullStr | The role of platelet-related parameters for the prediction of NAFLD in OSAHS patients |
| title_full_unstemmed | The role of platelet-related parameters for the prediction of NAFLD in OSAHS patients |
| title_short | The role of platelet-related parameters for the prediction of NAFLD in OSAHS patients |
| title_sort | role of platelet related parameters for the prediction of nafld in osahs patients |
| topic | Obstructive sleep apnea–hypopnea syndrome Non-alcoholic fatty liver disease Platelet to lymphocyte count ratio White blood cell count to mean platelet volume ratio |
| url | https://doi.org/10.1186/s12890-022-02291-6 |
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