Diabetes-Induced Changes in Macrophage Biology Might Lead to Reduced Risk for Abdominal Aortic Aneurysm Development
Type 2 diabetes patients are less likely to develop an abdominal aortic aneurysm (AAA). Since macrophages play a crucial role in AAA development, we hypothesized that this decrease in AAA risk in diabetic patients might be due to diabetes-induced changes in macrophage biology. To test this hypothesi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/2/128 |
| _version_ | 1797478111202246656 |
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| author | Giulia Chinetti Joseph Carboni Joseph Murdaca Claudine Moratal Brigitte Sibille Juliette Raffort Fabien Lareyre Elixène Jean Baptiste Réda Hassen-Khodja Jaap G. Neels |
| author_facet | Giulia Chinetti Joseph Carboni Joseph Murdaca Claudine Moratal Brigitte Sibille Juliette Raffort Fabien Lareyre Elixène Jean Baptiste Réda Hassen-Khodja Jaap G. Neels |
| author_sort | Giulia Chinetti |
| collection | DOAJ |
| description | Type 2 diabetes patients are less likely to develop an abdominal aortic aneurysm (AAA). Since macrophages play a crucial role in AAA development, we hypothesized that this decrease in AAA risk in diabetic patients might be due to diabetes-induced changes in macrophage biology. To test this hypothesis, we treated primary macrophages obtained from healthy human volunteers with serum from non-diabetic vs. diabetic AAA patients and observed differences in extracellular acidification and the expression of genes involved in glycolysis and lipid oxidation. These results suggest an increase in metabolism in macrophages treated with serum from diabetic AAA patients. Since serum samples used did not differ in glucose content, these changes are not likely to be caused by differences in glycemia. Macrophage functions have been shown to be linked to their metabolism. In line with this, our data suggest that this increase in macrophage metabolism is accompanied by a shift towards an anti-inflammatory state. Together, these results support a model where diabetes-induced changes in metabolism in macrophages might lead to a reduced risk for AAA development. |
| first_indexed | 2024-03-09T21:27:23Z |
| format | Article |
| id | doaj.art-46ac6c53d1fa4e7d9afbf7b6761a4bbe |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T21:27:23Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-46ac6c53d1fa4e7d9afbf7b6761a4bbe2023-11-23T21:04:51ZengMDPI AGMetabolites2218-19892022-01-0112212810.3390/metabo12020128Diabetes-Induced Changes in Macrophage Biology Might Lead to Reduced Risk for Abdominal Aortic Aneurysm DevelopmentGiulia Chinetti0Joseph Carboni1Joseph Murdaca2Claudine Moratal3Brigitte Sibille4Juliette Raffort5Fabien Lareyre6Elixène Jean Baptiste7Réda Hassen-Khodja8Jaap G. Neels9Centre Hospitalier Universitaire (CHU), Institut National de la Santé Et de la Recherche Médicale (INSERM), Centre Méditerranéen de Médecine Moléculaire (C3M), Université Côte d’Azur, 06200 Nice, FranceDepartment of Vascular Surgery, Centre Hospitalier Universitaire (CHU), 06000 Nice, FranceInstitut National de la Santé Et de la Recherche Médicale (INSERM), Centre Méditerranéen de Médecine Moléculaire (C3M), Université Côte d’Azur, 06200 Nice, FranceInstitut National de la Santé Et de la Recherche Médicale (INSERM), Centre Méditerranéen de Médecine Moléculaire (C3M), Université Côte d’Azur, 06200 Nice, FranceInstitut National de la Santé Et de la Recherche Médicale (INSERM), Centre Méditerranéen de Médecine Moléculaire (C3M), Université Côte d’Azur, 06200 Nice, FranceCentre Hospitalier Universitaire (CHU), Institut National de la Santé Et de la Recherche Médicale (INSERM), Centre Méditerranéen de Médecine Moléculaire (C3M), Université Côte d’Azur, 06200 Nice, FranceInstitut National de la Santé Et de la Recherche Médicale (INSERM), Centre Méditerranéen de Médecine Moléculaire (C3M), Université Côte d’Azur, 06200 Nice, FranceCentre Hospitalier Universitaire (CHU), Institut National de la Santé Et de la Recherche Médicale (INSERM), Centre Méditerranéen de Médecine Moléculaire (C3M), Université Côte d’Azur, 06200 Nice, FranceCentre Hospitalier Universitaire (CHU), Institut National de la Santé Et de la Recherche Médicale (INSERM), Centre Méditerranéen de Médecine Moléculaire (C3M), Université Côte d’Azur, 06200 Nice, FranceInstitut National de la Santé Et de la Recherche Médicale (INSERM), Centre Méditerranéen de Médecine Moléculaire (C3M), Université Côte d’Azur, 06200 Nice, FranceType 2 diabetes patients are less likely to develop an abdominal aortic aneurysm (AAA). Since macrophages play a crucial role in AAA development, we hypothesized that this decrease in AAA risk in diabetic patients might be due to diabetes-induced changes in macrophage biology. To test this hypothesis, we treated primary macrophages obtained from healthy human volunteers with serum from non-diabetic vs. diabetic AAA patients and observed differences in extracellular acidification and the expression of genes involved in glycolysis and lipid oxidation. These results suggest an increase in metabolism in macrophages treated with serum from diabetic AAA patients. Since serum samples used did not differ in glucose content, these changes are not likely to be caused by differences in glycemia. Macrophage functions have been shown to be linked to their metabolism. In line with this, our data suggest that this increase in macrophage metabolism is accompanied by a shift towards an anti-inflammatory state. Together, these results support a model where diabetes-induced changes in metabolism in macrophages might lead to a reduced risk for AAA development.https://www.mdpi.com/2218-1989/12/2/128macrophagesinflammationmetabolismtype 2 diabetes |
| spellingShingle | Giulia Chinetti Joseph Carboni Joseph Murdaca Claudine Moratal Brigitte Sibille Juliette Raffort Fabien Lareyre Elixène Jean Baptiste Réda Hassen-Khodja Jaap G. Neels Diabetes-Induced Changes in Macrophage Biology Might Lead to Reduced Risk for Abdominal Aortic Aneurysm Development Metabolites macrophages inflammation metabolism type 2 diabetes |
| title | Diabetes-Induced Changes in Macrophage Biology Might Lead to Reduced Risk for Abdominal Aortic Aneurysm Development |
| title_full | Diabetes-Induced Changes in Macrophage Biology Might Lead to Reduced Risk for Abdominal Aortic Aneurysm Development |
| title_fullStr | Diabetes-Induced Changes in Macrophage Biology Might Lead to Reduced Risk for Abdominal Aortic Aneurysm Development |
| title_full_unstemmed | Diabetes-Induced Changes in Macrophage Biology Might Lead to Reduced Risk for Abdominal Aortic Aneurysm Development |
| title_short | Diabetes-Induced Changes in Macrophage Biology Might Lead to Reduced Risk for Abdominal Aortic Aneurysm Development |
| title_sort | diabetes induced changes in macrophage biology might lead to reduced risk for abdominal aortic aneurysm development |
| topic | macrophages inflammation metabolism type 2 diabetes |
| url | https://www.mdpi.com/2218-1989/12/2/128 |
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