Combination Versus Monotherapy for the Treatment of HIV Associated Cryptococcal Meningitis
Objective: To study the efficacy of anti Cryptococcal treatment by cerebrospinal fluid (CSF) fungal negativity after two weeks of treatment with amphotericin B alone or combined with fluconazole in treatment of HIV associated Cryptococcal meningitis (CM). Materials and Methods: A total of 84 hu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5601/12360_CE[Ra]_F(P)_PF1(NJAK)_PFA(AK)_PF2(PAG).pdf |
| _version_ | 1811264261569118208 |
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| author | Shashank Anant Vaidhya Bharat Bhushan Gupta Rajesh Kumar Jha Ravindra Kumar |
| author_facet | Shashank Anant Vaidhya Bharat Bhushan Gupta Rajesh Kumar Jha Ravindra Kumar |
| author_sort | Shashank Anant Vaidhya |
| collection | DOAJ |
| description | Objective: To study the efficacy of anti Cryptococcal treatment
by cerebrospinal fluid (CSF) fungal negativity after two weeks
of treatment with amphotericin B alone or combined with
fluconazole in treatment of HIV associated Cryptococcal
meningitis (CM).
Materials and Methods: A total of 84 human immunodeficiency
virus (HIV) associated CM patients confirmed by CSF culture
positivity were recruited for the study. Patients were randomly
divided into two groups. Group A was given amphotericin B
alone whereas Amphotericin B in combination with fluconazole
was given in group B for the treatment of CM. Patients were
followed for 14 days.
Results: Maximum number of patients was in the age group
21-49 y. All the 84 patients had <100 CD4 counts/μl. After 14
days of the treatment in group A and B, there was no significant
difference in terms of fever, headache and neck stiffness as a
clinical outcome. But in group B there was improved in altered
sensorium and focal neurological deficit as compared to group
A. After 14 days of the treatment CSF culture negativity was
more in group B as compared to group A.
Conclusion: Amphotericin B in combination with fluconazole is
recommended for the treatment of HIV associated CM. |
| first_indexed | 2024-04-12T20:00:56Z |
| format | Article |
| id | doaj.art-46ad09fed85f4f938efae58eff08be79 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-12T20:00:56Z |
| publishDate | 2015-02-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-46ad09fed85f4f938efae58eff08be792022-12-22T03:18:32ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-02-0192OC14OC1610.7860/JCDR/2015/12360.5601Combination Versus Monotherapy for the Treatment of HIV Associated Cryptococcal MeningitisShashank Anant Vaidhya0Bharat Bhushan Gupta1Rajesh Kumar Jha2Ravindra Kumar3Associate Professor, Department of Medicine, Sri Aurobindo Medical College and PG Insitute, Indore, India.Associate Professor, Department of Medicine, Sri Aurobindo Medical College and PG Insitute, Indore, India.Professor and Head, Department of Medicine, Sri Aurobindo Medical College and PG Insitute, Indore, India.Scientist, Central Research Laboratory, Sri Aurobindo Medical College and PG Insitute, Indore, India.Objective: To study the efficacy of anti Cryptococcal treatment by cerebrospinal fluid (CSF) fungal negativity after two weeks of treatment with amphotericin B alone or combined with fluconazole in treatment of HIV associated Cryptococcal meningitis (CM). Materials and Methods: A total of 84 human immunodeficiency virus (HIV) associated CM patients confirmed by CSF culture positivity were recruited for the study. Patients were randomly divided into two groups. Group A was given amphotericin B alone whereas Amphotericin B in combination with fluconazole was given in group B for the treatment of CM. Patients were followed for 14 days. Results: Maximum number of patients was in the age group 21-49 y. All the 84 patients had <100 CD4 counts/μl. After 14 days of the treatment in group A and B, there was no significant difference in terms of fever, headache and neck stiffness as a clinical outcome. But in group B there was improved in altered sensorium and focal neurological deficit as compared to group A. After 14 days of the treatment CSF culture negativity was more in group B as compared to group A. Conclusion: Amphotericin B in combination with fluconazole is recommended for the treatment of HIV associated CM.https://jcdr.net/articles/PDF/5601/12360_CE[Ra]_F(P)_PF1(NJAK)_PFA(AK)_PF2(PAG).pdfamphotericin bcombination therapycryptococcal meningitisfluconazolehiv |
| spellingShingle | Shashank Anant Vaidhya Bharat Bhushan Gupta Rajesh Kumar Jha Ravindra Kumar Combination Versus Monotherapy for the Treatment of HIV Associated Cryptococcal Meningitis Journal of Clinical and Diagnostic Research amphotericin b combination therapy cryptococcal meningitis fluconazole hiv |
| title | Combination Versus Monotherapy for the Treatment of HIV Associated Cryptococcal Meningitis |
| title_full | Combination Versus Monotherapy for the Treatment of HIV Associated Cryptococcal Meningitis |
| title_fullStr | Combination Versus Monotherapy for the Treatment of HIV Associated Cryptococcal Meningitis |
| title_full_unstemmed | Combination Versus Monotherapy for the Treatment of HIV Associated Cryptococcal Meningitis |
| title_short | Combination Versus Monotherapy for the Treatment of HIV Associated Cryptococcal Meningitis |
| title_sort | combination versus monotherapy for the treatment of hiv associated cryptococcal meningitis |
| topic | amphotericin b combination therapy cryptococcal meningitis fluconazole hiv |
| url | https://jcdr.net/articles/PDF/5601/12360_CE[Ra]_F(P)_PF1(NJAK)_PFA(AK)_PF2(PAG).pdf |
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