Associations between vitamin D, immunoglobulin E concentrations, and obesity
The prevalence of allergies and obesity has been increased in parallel. Low vitamin D [25(OH)D] levels have been linked to both higher body mass index (BMI) and allergies. Since the activation of the 25(OH)D receptor inhibits IgE production and 25(OH)D influences the IgE response specifically, we te...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1147407/full |
| _version_ | 1797856407648731136 |
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| author | Angelica Avila Castillo Tobias Hagemann Anne Hoffmann Ronny Baber Ronny Baber Ronald Biemann Kerstin Wirkner Sontje Krupka Michael Stumvoll Michael Stumvoll Matthias Blüher Matthias Blüher Matthias Blüher Nora Klöting Nora Klöting |
| author_facet | Angelica Avila Castillo Tobias Hagemann Anne Hoffmann Ronny Baber Ronny Baber Ronald Biemann Kerstin Wirkner Sontje Krupka Michael Stumvoll Michael Stumvoll Matthias Blüher Matthias Blüher Matthias Blüher Nora Klöting Nora Klöting |
| author_sort | Angelica Avila Castillo |
| collection | DOAJ |
| description | The prevalence of allergies and obesity has been increased in parallel. Low vitamin D [25(OH)D] levels have been linked to both higher body mass index (BMI) and allergies. Since the activation of the 25(OH)D receptor inhibits IgE production and 25(OH)D influences the IgE response specifically, we tested the hypothesis that circulating 25(OH)D concentrations are negatively related to circulating allergen-specific IgE concentrations distinctly in a large adult population-based study cohort. Moreover, we studied VDR gene expression in paired biopsies of abdominal subcutaneous (SAT) and visceral adipose tissue (VAT). We investigated whether magnetic resonance imaging-estimated visceral (VFM) and subcutaneous fat mass (SFM) are related to 25(OH)D levels. We found gender differences in circulating 25(OH)D and IgE concentrations. Participants with obesity showed lower 25(OH)D concentrations and higher IgE concentrations were detected in women only. Interestingly, participants with high levels of 25(OH)D are leaner and have improved glucose metabolism. In women, 25(OH)D correlate significant with VFM and SFM. VDR expression is significantly higher expressed in VAT and is positive associated with circulating 25(OH)D concentration. There was no association between serum IgE and 25(OH)D in the entire cohort. Based on these data, we could confirm that low levels of 25(OH)D are linked to higher BMI but could not prove our hypothesis because there is no relationship between 25(OH)D and IgE in adults. Women with higher BMI tend to have higher IgE levels what may have clinical relevance. The association between obesity and circulating 25(OH)D/IgE is not straightforward, and further knowledge is needed. |
| first_indexed | 2024-04-09T20:39:59Z |
| format | Article |
| id | doaj.art-46af6e6e5bdc4ebbbf1a1855d606a691 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-09T20:39:59Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-46af6e6e5bdc4ebbbf1a1855d606a6912023-03-30T04:34:03ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-03-011010.3389/fnut.2023.11474071147407Associations between vitamin D, immunoglobulin E concentrations, and obesityAngelica Avila Castillo0Tobias Hagemann1Anne Hoffmann2Ronny Baber3Ronny Baber4Ronald Biemann5Kerstin Wirkner6Sontje Krupka7Michael Stumvoll8Michael Stumvoll9Matthias Blüher10Matthias Blüher11Matthias Blüher12Nora Klöting13Nora Klöting14Medical Department III–Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, GermanyHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München, University of Leipzig and University Hospital Leipzig, Leipzig, GermanyHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München, University of Leipzig and University Hospital Leipzig, Leipzig, GermanyLIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, GermanyInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University Hospital Leipzig, Leipzig, GermanyInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University Hospital Leipzig, Leipzig, GermanyLIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, GermanyHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München, University of Leipzig and University Hospital Leipzig, Leipzig, GermanyMedical Department III–Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, GermanyHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München, University of Leipzig and University Hospital Leipzig, Leipzig, GermanyMedical Department III–Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, GermanyHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München, University of Leipzig and University Hospital Leipzig, Leipzig, GermanyGerman Center for Diabetes Research (DZD e.V.), München-Neuherberg, GermanyMedical Department III–Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, GermanyHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München, University of Leipzig and University Hospital Leipzig, Leipzig, GermanyThe prevalence of allergies and obesity has been increased in parallel. Low vitamin D [25(OH)D] levels have been linked to both higher body mass index (BMI) and allergies. Since the activation of the 25(OH)D receptor inhibits IgE production and 25(OH)D influences the IgE response specifically, we tested the hypothesis that circulating 25(OH)D concentrations are negatively related to circulating allergen-specific IgE concentrations distinctly in a large adult population-based study cohort. Moreover, we studied VDR gene expression in paired biopsies of abdominal subcutaneous (SAT) and visceral adipose tissue (VAT). We investigated whether magnetic resonance imaging-estimated visceral (VFM) and subcutaneous fat mass (SFM) are related to 25(OH)D levels. We found gender differences in circulating 25(OH)D and IgE concentrations. Participants with obesity showed lower 25(OH)D concentrations and higher IgE concentrations were detected in women only. Interestingly, participants with high levels of 25(OH)D are leaner and have improved glucose metabolism. In women, 25(OH)D correlate significant with VFM and SFM. VDR expression is significantly higher expressed in VAT and is positive associated with circulating 25(OH)D concentration. There was no association between serum IgE and 25(OH)D in the entire cohort. Based on these data, we could confirm that low levels of 25(OH)D are linked to higher BMI but could not prove our hypothesis because there is no relationship between 25(OH)D and IgE in adults. Women with higher BMI tend to have higher IgE levels what may have clinical relevance. The association between obesity and circulating 25(OH)D/IgE is not straightforward, and further knowledge is needed.https://www.frontiersin.org/articles/10.3389/fnut.2023.1147407/full25(OH)Dvitamin DIgEadipose tissueBMIobesity |
| spellingShingle | Angelica Avila Castillo Tobias Hagemann Anne Hoffmann Ronny Baber Ronny Baber Ronald Biemann Kerstin Wirkner Sontje Krupka Michael Stumvoll Michael Stumvoll Matthias Blüher Matthias Blüher Matthias Blüher Nora Klöting Nora Klöting Associations between vitamin D, immunoglobulin E concentrations, and obesity Frontiers in Nutrition 25(OH)D vitamin D IgE adipose tissue BMI obesity |
| title | Associations between vitamin D, immunoglobulin E concentrations, and obesity |
| title_full | Associations between vitamin D, immunoglobulin E concentrations, and obesity |
| title_fullStr | Associations between vitamin D, immunoglobulin E concentrations, and obesity |
| title_full_unstemmed | Associations between vitamin D, immunoglobulin E concentrations, and obesity |
| title_short | Associations between vitamin D, immunoglobulin E concentrations, and obesity |
| title_sort | associations between vitamin d immunoglobulin e concentrations and obesity |
| topic | 25(OH)D vitamin D IgE adipose tissue BMI obesity |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1147407/full |
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