CARD9 Signaling in Intestinal Immune Homeostasis and Oncogenesis
Intestinal homeostasis requires a balanced interaction between the host innate immune system and the gut microbiota. A dysregulation of this interdependency can result in inflammatory bowel diseases (IBDs), and this dysregulation is a key pathogenic factor during the development of colorectal cancer...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.00419/full |
| _version_ | 1828320326965002240 |
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| author | Lara Hartjes Jürgen Ruland Jürgen Ruland Jürgen Ruland |
| author_facet | Lara Hartjes Jürgen Ruland Jürgen Ruland Jürgen Ruland |
| author_sort | Lara Hartjes |
| collection | DOAJ |
| description | Intestinal homeostasis requires a balanced interaction between the host innate immune system and the gut microbiota. A dysregulation of this interdependency can result in inflammatory bowel diseases (IBDs), and this dysregulation is a key pathogenic factor during the development of colorectal cancer. CARD9 is a central signaling molecule in the innate immune system, which is essential for host defense against infection. Moreover, polymorphisms in CARD9 are key risk factors for IBD development, indicating that CARD9 signaling is critical for intestinal immune homeostasis. This review summarizes recent insights into the regulation of CARD9 signaling, its pathophysiological role during IBD development via effects on the microbiota and epithelial regeneration and the pro- and antitumor immune functions of CARD9 during intestinal carcinogenesis. |
| first_indexed | 2024-04-13T18:10:07Z |
| format | Article |
| id | doaj.art-46b0df7ea6294bc48685dd207ba741a2 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T18:10:07Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-46b0df7ea6294bc48685dd207ba741a22022-12-22T02:35:56ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-03-011010.3389/fimmu.2019.00419440867CARD9 Signaling in Intestinal Immune Homeostasis and OncogenesisLara Hartjes0Jürgen Ruland1Jürgen Ruland2Jürgen Ruland3Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Technical University of Munich, Munich, GermanyInstitute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Technical University of Munich, Munich, GermanyGerman Cancer Consortium (DKTK), Heidelberg, GermanyGerman Center for Infection Research (DZIF), Munich, GermanyIntestinal homeostasis requires a balanced interaction between the host innate immune system and the gut microbiota. A dysregulation of this interdependency can result in inflammatory bowel diseases (IBDs), and this dysregulation is a key pathogenic factor during the development of colorectal cancer. CARD9 is a central signaling molecule in the innate immune system, which is essential for host defense against infection. Moreover, polymorphisms in CARD9 are key risk factors for IBD development, indicating that CARD9 signaling is critical for intestinal immune homeostasis. This review summarizes recent insights into the regulation of CARD9 signaling, its pathophysiological role during IBD development via effects on the microbiota and epithelial regeneration and the pro- and antitumor immune functions of CARD9 during intestinal carcinogenesis.https://www.frontiersin.org/article/10.3389/fimmu.2019.00419/fullCARD9intestinal immune homeostasisinflammatory bowel diseaseintestinal inflammationintestinal carcinogenesisgut microbiome |
| spellingShingle | Lara Hartjes Jürgen Ruland Jürgen Ruland Jürgen Ruland CARD9 Signaling in Intestinal Immune Homeostasis and Oncogenesis Frontiers in Immunology CARD9 intestinal immune homeostasis inflammatory bowel disease intestinal inflammation intestinal carcinogenesis gut microbiome |
| title | CARD9 Signaling in Intestinal Immune Homeostasis and Oncogenesis |
| title_full | CARD9 Signaling in Intestinal Immune Homeostasis and Oncogenesis |
| title_fullStr | CARD9 Signaling in Intestinal Immune Homeostasis and Oncogenesis |
| title_full_unstemmed | CARD9 Signaling in Intestinal Immune Homeostasis and Oncogenesis |
| title_short | CARD9 Signaling in Intestinal Immune Homeostasis and Oncogenesis |
| title_sort | card9 signaling in intestinal immune homeostasis and oncogenesis |
| topic | CARD9 intestinal immune homeostasis inflammatory bowel disease intestinal inflammation intestinal carcinogenesis gut microbiome |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.00419/full |
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