Autonomic Nervous System Dysfunction Is Related to Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common and non-lethal urological condition with painful symptoms. The complexity of CP/CPPS’s pathogenesis and lack of efficient etiological diagnosis results in incomplete treatment and recurrent episodes, causing long-term mental an...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society for Sexual Medicine and Andrology
2024-01-01
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| Series: | The World Journal of Men's Health |
| Subjects: |
| Summary: | Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common and non-lethal urological condition with painful
symptoms. The complexity of CP/CPPS’s pathogenesis and lack of efficient etiological diagnosis results in incomplete treatment
and recurrent episodes, causing long-term mental and psychological suffering in patients. Recent findings indicate that
the autonomic nervous system involves in CP/CPPS, including sensory, sympathetic, parasympathetic, and central nervous
systems. Neuro-inflammation and sensitization of sensory nerves lead to persistent inflammation and pain. Sympathetic and
parasympathetic alterations affect the cardiovascular and reproductive systems and the development of prostatitis. Central
sensitization lowers pain thresholds and increases pelvic pain perception in chronic prostatitis. Therefore, this review summarized
the detailed processes and mechanisms of the critical role of the autonomic nervous system in developing CP/CPPS.
Furthermore, it describes the neurologically relevant substances and channels or receptors involved in this process, which
provides new perspectives for new therapeutic approaches to CP/CPPS. |
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| ISSN: | 2287-4208 2287-4690 |