Exercise training has restorative potential on myocardial energy metabolism in rats with chronic heart failure
Objective(s): Exercise training is a well-known accelerator for the treatment of chronic heart failure (CHF). The current study aimed to investigate the restorative effects of aerobic interval training (AIT) intervention on myocardial energy metabolism in CHF rats. Materials and Methods: Post-myocar...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2018-08-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/article_11034_d9b7bbe370b6dd03278ba47d38456445.pdf |
| _version_ | 1811316155050098688 |
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| author | Li Wang Kai Gao Dan Wang |
| author_facet | Li Wang Kai Gao Dan Wang |
| author_sort | Li Wang |
| collection | DOAJ |
| description | Objective(s): Exercise training is a well-known accelerator for the treatment of chronic heart failure (CHF). The current study aimed to investigate the restorative effects of aerobic interval training (AIT) intervention on myocardial energy metabolism in CHF rats. Materials and Methods: Post-myocardial infarction (MI) heart failure animal model was established. The Sprague-Dawley rats were randomly divided into sham operation group (Sham group), CHF model group, and CHF exercise group (Exercise-CHF group). Results: Our data showed that when compared to the Sham group, the left ventricular systolic pressure (LVSP), myocardial glycogen content, and expression levels of key components of AMP-activated protein kinase (AMPK) pathway were decreased significantly (P |
| first_indexed | 2024-04-13T11:44:56Z |
| format | Article |
| id | doaj.art-46b49b041b734af0b2b7dbb5539144d0 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-04-13T11:44:56Z |
| publishDate | 2018-08-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-46b49b041b734af0b2b7dbb5539144d02022-12-22T02:48:13ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742018-08-0121881882310.22038/ijbms.2018.29294.707611034Exercise training has restorative potential on myocardial energy metabolism in rats with chronic heart failureLi Wang0Kai Gao1Dan Wang2Department of Physical Education, Shandong University, Weihai, Weihai 264209, Shandong Province, ChinaMedical Imaging Faculty, Weifang Medical University, Weifang 261053, Shandong Province, ChinaDivision of physical education, General course Teaching Department, Weifang Medical University, Weifang 261053, Shandong Province, ChinaObjective(s): Exercise training is a well-known accelerator for the treatment of chronic heart failure (CHF). The current study aimed to investigate the restorative effects of aerobic interval training (AIT) intervention on myocardial energy metabolism in CHF rats. Materials and Methods: Post-myocardial infarction (MI) heart failure animal model was established. The Sprague-Dawley rats were randomly divided into sham operation group (Sham group), CHF model group, and CHF exercise group (Exercise-CHF group). Results: Our data showed that when compared to the Sham group, the left ventricular systolic pressure (LVSP), myocardial glycogen content, and expression levels of key components of AMP-activated protein kinase (AMPK) pathway were decreased significantly (Phttp://ijbms.mums.ac.ir/article_11034_d9b7bbe370b6dd03278ba47d38456445.pdfBasal metabolismBlood pressureExerciseFatty acidheart failureMyocardial infarction |
| spellingShingle | Li Wang Kai Gao Dan Wang Exercise training has restorative potential on myocardial energy metabolism in rats with chronic heart failure Iranian Journal of Basic Medical Sciences Basal metabolism Blood pressure Exercise Fatty acid heart failure Myocardial infarction |
| title | Exercise training has restorative potential on myocardial energy metabolism in rats with chronic heart failure |
| title_full | Exercise training has restorative potential on myocardial energy metabolism in rats with chronic heart failure |
| title_fullStr | Exercise training has restorative potential on myocardial energy metabolism in rats with chronic heart failure |
| title_full_unstemmed | Exercise training has restorative potential on myocardial energy metabolism in rats with chronic heart failure |
| title_short | Exercise training has restorative potential on myocardial energy metabolism in rats with chronic heart failure |
| title_sort | exercise training has restorative potential on myocardial energy metabolism in rats with chronic heart failure |
| topic | Basal metabolism Blood pressure Exercise Fatty acid heart failure Myocardial infarction |
| url | http://ijbms.mums.ac.ir/article_11034_d9b7bbe370b6dd03278ba47d38456445.pdf |
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