Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model.

Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model.

The treatment of brain diseases is hindered by the blood-brain barrier (BBB) preventing most drugs from entering the brain. Focused ultrasound (FUS) with microbubbles can open the BBB safely and reversibly. Systemic drug injection might induce toxicity, but encapsulation into nanoparticles reduces a...

Full description

Bibliographic Details
Main Authors:	Habib Baghirov, Sofie Snipstad, Einar Sulheim, Sigrid Berg, Rune Hansen, Frits Thorsen, Yrr Mørch, Catharina de Lange Davies, Andreas K O Åslund
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2018-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC5770053?pdf=render

Similar Items

Sonoporation Using Nanoparticle-Loaded Microbubbles Increases Cellular Uptake of Nanoparticles Compared to Co-Incubation of Nanoparticles and Microbubbles
by: Sofie Snipstad, et al.
Published: (2021-04-01)

Characterization of immune cell populations in syngeneic murine tumor models
by: Sofie Snipstad, et al.
Published: (2023-05-01)

Identification of novel cyanoacrylate monomers for use in nanoparticle drug delivery systems prepared by miniemulsion polymerisation – A multistep screening approach
by: Astrid Hyldbakk, et al.
Published: (2022-12-01)

Real-Time Multiphoton Intravital Microscopy of Drug Extravasation in Tumours during Acoustic Cluster Therapy
by: Jessica Lage Fernandez, et al.
Published: (2024-02-01)

Transcranial brain parenchyma sonography in movement disorders
by: Ya⁃nan QIAO, et al.
Published: (2012-10-01)

Early invasion of brain parenchyma by African trypanosomes.
by: Ute Frevert, et al.
Published: (2012-01-01)

Longitudinal changes in brain parenchyma due to mild traumatic brain injury during the first year after injury
by: Angela M. Muller, et al.
Published: (2021-12-01)

A simple damage and fracture model of brain parenchyma for haptic brain surgery simulations
by: Xiaoshuai CHEN, et al.
Published: (2016-10-01)

Assessment of α-synuclein secretion in mouse and human brain parenchyma.
by: Evangelia Emmanouilidou, et al.
Published: (2011-01-01)

Altered diffusion tensor imaging (DTI) parameters in brain parenchyma after traumatic brain injury
by: Lamiaa Galal Elsorogy, et al.
Published: (2022-12-01)

Uncoupling of virus-induced inflammation and anti-viral immunity in the brain parenchyma.
by: Stevenson, P, et al.
Published: (2002)

Diffusion-weighted imaging findings of brain parenchyma in pediatric pseudotumor cerebri
by: Esra Meltem Kayahan Ulu, et al.
Published: (2022-03-01)

Validation of brain parenchyma sonography as a marker of neurodegeneration in multiple sclerosis
by: Nirmeen A. Kishk, et al.
Published: (2023-10-01)

Clinicopathological analysis of unusual rosette-forming glioneuronal tumor in brain parenchyma
by: Da-wei LIU, et al.
Published: (2014-03-01)

Stroke induces disease-specific myeloid cells in the brain parenchyma and pia
by: Carolin Beuker, et al.
Published: (2022-02-01)

A Comparative Analysis of Orthotopic and Subcutaneous Pancreatic Tumour Models: Tumour Microenvironment and Drug Delivery
by: Jessica Lage Fernandez, et al.
Published: (2023-11-01)

Biodistribution of Poly(alkyl cyanoacrylate) Nanoparticles in Mice and Effect on Tumor Infiltration of Macrophages into a Patient-Derived Breast Cancer Xenograft
by: Abhilash D. Pandya, et al.
Published: (2021-04-01)

Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier
by: Stephen B. Hladky, et al.
Published: (2018-10-01)

An Experimental Study of Relationship Between Magnetic Induction Phase Shift and Brain Parenchyma Volume With Brain Edema in Traumatic Brain Injury
by: Shuanglin Zhao, et al.
Published: (2019-01-01)

Segmentation of Substantia Nigra in Brain Parenchyma Sonographic Images Using Deep Learning
by: Giansalvo Gusinu, et al.
Published: (2023-12-01)

Magnetic resonance imaging analysis predicts nanoparticle concentration delivered to the brain parenchyma
by: Michael Plaksin, et al.
Published: (2022-09-01)

Transcranial brain parenchyma sonographic findings in patients with myotonic dystrophy type 1 and 2
by: Milija Mijajlovic, et al.
Published: (2024-03-01)

Structural MRI in Migraine: A Review of Migraine Vascular and Structural Changes in Brain Parenchyma
by: Wilson J Xu B.A, et al.
Published: (2023-03-01)

Chronic pathophysiological changes in the normal brain parenchyma caused by radiotherapy accelerate glioma progression
by: Yuichiro Tsuji, et al.
Published: (2021-11-01)

Angioside: The role of Angiogenesis and Hypoxia in Lung Neuroendocrine Tumours According to Primary Tumour Location in Left or Right Parenchyma
by: Anna La Salvia, et al.
Published: (2022-10-01)

Detection of SARS-CoV-2 RNA by In Situ Hybridization in Lung-Cancer Cells Metastatic to Brain and in Adjacent Brain Parenchyma
by: Tibor Valyi-Nagy, et al.
Published: (2023-05-01)

Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human
by: Wandong Zhang, et al.
Published: (2020-07-01)

The neuropsychiatry of brain tumours
by: Piet Oosthizen
Published: (2005-04-01)

Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus
by: Clara Muñoz-Castro, et al.
Published: (2023-02-01)

Deep learning-based segmentation of brain parenchyma and ventricular system in CT scans in the presence of anomalies
by: Annika Gerken, et al.
Published: (2023-08-01)

Editorial: The Role of the Immune Response in Brain Metastasis
by: Nicola R. Sibson, et al.
Published: (2022-05-01)

Feasibility Study of the Permeability and Uptake of Mesoporous Silica Nanoparticles across the Blood-Brain Barrier.
by: Habib Baghirov, et al.
Published: (2016-01-01)

Cytotoxicity of Poly(Alkyl Cyanoacrylate) Nanoparticles
by: Einar Sulheim, et al.
Published: (2017-11-01)

Gender disparities in brain tumours: A Pakistan brain tumour epidemiology study analysis
by: Mashal Murad Shah, et al.
Published: (2022-12-01)

Intrathecal activation of CD8+ memory T cells in IgG4‐related disease of the brain parenchyma
by: Mirco Friedrich, et al.
Published: (2021-08-01)

The role of tumor parenchyma and brain cortex signal intensity ratio in differentiating solitary fibrous tumors and meningiomas
by: Yue Yu, et al.
Published: (2024-02-01)

γδ T cells recruitment and local proliferation in brain parenchyma benefit anti-neuroinflammation after cerebral microbleeds
by: Xin Su, et al.
Published: (2023-03-01)

Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma
by: Alex J Smith, et al.
Published: (2017-08-01)

Value of dual energy CT in post resuscitation coma. Differentiating contrast retention and ischemic brain parenchyma
by: Asra Nayab, MBBS, et al.
Published: (2022-10-01)

Intra-Arterially Delivered Mesenchymal Stem Cells Are Not Detected in the Brain Parenchyma in an Alzheimer's Disease Mouse Model.
by: Na Kyung Lee, et al.
Published: (2016-01-01)