Biogenic Ceria Nanoparticles (CeO<sub>2</sub> NPs) for Effective Photocatalytic and Cytotoxic Activity
Ceria nanoparticles (CeO<sub>2</sub> NPs) are generally considered in various functional applications, such as catalysts in fuel cells, sensors, and antioxidant and oxidase-like enzymes in the biological environment. The CeO<sub>2</sub> NPs were synthesized using the <i>...
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MDPI AG
2020-03-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/7/1/26 |
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| author | Siripireddy Balaji Badal Kumar Mandal L. Vinod Kumar Reddy Dwaipayan Sen |
| author_facet | Siripireddy Balaji Badal Kumar Mandal L. Vinod Kumar Reddy Dwaipayan Sen |
| author_sort | Siripireddy Balaji |
| collection | DOAJ |
| description | Ceria nanoparticles (CeO<sub>2</sub> NPs) are generally considered in various functional applications, such as catalysts in fuel cells, sensors, and antioxidant and oxidase-like enzymes in the biological environment. The CeO<sub>2</sub> NPs were synthesized using the <i>E. globulus</i> leaf extract-mediated hydrothermal technique. The synthesized NPs were characterized by various analytical instruments including powder X-ray diffractometer (PXRD), scanning electron microscope (SEM), transmission electron microscope (TEM) and dynamic light scattering (DLS) analysis. The XRD results showed an average NPs sizes of 13.7 nm. Cytotoxic study results showed an IC<sub>50</sub> value of 45.5 µg/L for A549 and 58.2 µg/L for HCT 116, indicating that CeO<sub>2</sub> NPs are more toxic to A549 compared to HCT116 cell lines. The generation of ROS was responsible for its cytotoxic activity against cancer cell lines. Specific surface area (40.96 m<sup>2</sup>/g) and pore diameter (7.8 nm) were measured using Brunauer–Emmett–Teller (BET) nitrogen adsorption–desorption isotherms. CeO<sub>2</sub> NPs with a high surface area were used as photocatalyst in degrading sunset yellow (SY) dye under UV-irradiation and 97.3% of the dye was degraded within 90 min. These results suggest that the synthesized CeO<sub>2</sub> NPs could be used as a good photocatalyst as well as a cytotoxic agent against human cancer cell lines. |
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| language | English |
| last_indexed | 2024-03-12T11:00:24Z |
| publishDate | 2020-03-01 |
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| series | Bioengineering |
| spelling | doaj.art-46b5c887defd4765961c6c866aa446c52023-09-02T05:45:00ZengMDPI AGBioengineering2306-53542020-03-01712610.3390/bioengineering7010026bioengineering7010026Biogenic Ceria Nanoparticles (CeO<sub>2</sub> NPs) for Effective Photocatalytic and Cytotoxic ActivitySiripireddy Balaji0Badal Kumar Mandal1L. Vinod Kumar Reddy2Dwaipayan Sen3Trace Elements Speciation Research Laboratory, Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, IndiaTrace Elements Speciation Research Laboratory, Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014, IndiaCellular and Molecular Therapeutics Laboratory, Centre for Biomaterials, Cellular and Molecular Theranostics, Vellore Institute of Technology, Vellore 632014, IndiaCellular and Molecular Therapeutics Laboratory, Centre for Biomaterials, Cellular and Molecular Theranostics, Vellore Institute of Technology, Vellore 632014, IndiaCeria nanoparticles (CeO<sub>2</sub> NPs) are generally considered in various functional applications, such as catalysts in fuel cells, sensors, and antioxidant and oxidase-like enzymes in the biological environment. The CeO<sub>2</sub> NPs were synthesized using the <i>E. globulus</i> leaf extract-mediated hydrothermal technique. The synthesized NPs were characterized by various analytical instruments including powder X-ray diffractometer (PXRD), scanning electron microscope (SEM), transmission electron microscope (TEM) and dynamic light scattering (DLS) analysis. The XRD results showed an average NPs sizes of 13.7 nm. Cytotoxic study results showed an IC<sub>50</sub> value of 45.5 µg/L for A549 and 58.2 µg/L for HCT 116, indicating that CeO<sub>2</sub> NPs are more toxic to A549 compared to HCT116 cell lines. The generation of ROS was responsible for its cytotoxic activity against cancer cell lines. Specific surface area (40.96 m<sup>2</sup>/g) and pore diameter (7.8 nm) were measured using Brunauer–Emmett–Teller (BET) nitrogen adsorption–desorption isotherms. CeO<sub>2</sub> NPs with a high surface area were used as photocatalyst in degrading sunset yellow (SY) dye under UV-irradiation and 97.3% of the dye was degraded within 90 min. These results suggest that the synthesized CeO<sub>2</sub> NPs could be used as a good photocatalyst as well as a cytotoxic agent against human cancer cell lines.https://www.mdpi.com/2306-5354/7/1/26<i>e. globulus</i> extractceo<sub>2</sub> npsphotocatalytic activityhuman carcinoma cellsroscytotoxic activity |
| spellingShingle | Siripireddy Balaji Badal Kumar Mandal L. Vinod Kumar Reddy Dwaipayan Sen Biogenic Ceria Nanoparticles (CeO<sub>2</sub> NPs) for Effective Photocatalytic and Cytotoxic Activity Bioengineering <i>e. globulus</i> extract ceo<sub>2</sub> nps photocatalytic activity human carcinoma cells ros cytotoxic activity |
| title | Biogenic Ceria Nanoparticles (CeO<sub>2</sub> NPs) for Effective Photocatalytic and Cytotoxic Activity |
| title_full | Biogenic Ceria Nanoparticles (CeO<sub>2</sub> NPs) for Effective Photocatalytic and Cytotoxic Activity |
| title_fullStr | Biogenic Ceria Nanoparticles (CeO<sub>2</sub> NPs) for Effective Photocatalytic and Cytotoxic Activity |
| title_full_unstemmed | Biogenic Ceria Nanoparticles (CeO<sub>2</sub> NPs) for Effective Photocatalytic and Cytotoxic Activity |
| title_short | Biogenic Ceria Nanoparticles (CeO<sub>2</sub> NPs) for Effective Photocatalytic and Cytotoxic Activity |
| title_sort | biogenic ceria nanoparticles ceo sub 2 sub nps for effective photocatalytic and cytotoxic activity |
| topic | <i>e. globulus</i> extract ceo<sub>2</sub> nps photocatalytic activity human carcinoma cells ros cytotoxic activity |
| url | https://www.mdpi.com/2306-5354/7/1/26 |
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