CRISPR/Cas9: A Powerful Strategy to Improve CAR-T Cell Persistence

CRISPR/Cas9: A Powerful Strategy to Improve CAR-T Cell Persistence

As an emerging treatment strategy for malignant tumors, chimeric antigen receptor T (CAR-T) cell therapy has been widely used in clinical practice, and its efficacy has been markedly improved in the past decade. However, the clinical effect of CAR-T therapy is not so satisfying, especially in solid...

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Bibliographic Details
Main Authors: Wei Wei, Zhi-Nan Chen, Ke Wang
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
CAR-T cell
CRISPR/Cas9
persistence
memory phenotype
exhaustion
Online Access:https://www.mdpi.com/1422-0067/24/15/12317

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