Detection of subclinical anthracycline induced cardiotoxicity in breast cancer survivors
Aims : To assess the chronic cardiac effects of anthracycline-based chemotherapy regimens on atrial and ventricular diameter, ejection fraction, and valvular abnormalities in relation to cumulative dose in breast cancer patients. Materials and Methods: Breast cancer patients who had received anthrac...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | CHRISMED Journal of Health and Research |
| Subjects: | |
| Online Access: | http://www.cjhr.org/article.asp?issn=2348-3334;year=2014;volume=1;issue=1;spage=36;epage=39;aulast=Negi |
| _version_ | 1818022910304976896 |
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| author | Preety Negi Pamela Alice Kingsley Sandeep Chopra Navneet Kumar Chaudhry Manmohan Krishan Mahajan |
| author_facet | Preety Negi Pamela Alice Kingsley Sandeep Chopra Navneet Kumar Chaudhry Manmohan Krishan Mahajan |
| author_sort | Preety Negi |
| collection | DOAJ |
| description | Aims : To assess the chronic cardiac effects of anthracycline-based chemotherapy regimens on atrial and ventricular diameter, ejection fraction, and valvular abnormalities in relation to cumulative dose in breast cancer patients. Materials and Methods: Breast cancer patients who had received anthracycline-based chemotherapy and radiation therapy were enrolled. All patients had undergone a baseline and follow-up electrocardiogrphy, echocardiography, and clinical cardiac evaluation. Any changes in cardiac parameters were noted. Statistical Analysis Used: Statistical measures used were Chi-square test and independent t-test. Results: A total of 75 breast cancer patients were assessed. Out of these, 56 patients who received cumulative dose of doxorubicin ≥300 mg/m 2 showed increased cardiac dysfunction. Patients with left side breast cancer had greater cardiac abnormalities compared with right side. Conclusion: Cardiac dysfunction was significant with cumulative dose of doxorubicin ≥300 mg/m 2 and also was observed more in left side breast cancer patients. |
| first_indexed | 2024-12-10T03:35:56Z |
| format | Article |
| id | doaj.art-46b8796ea9ad4ef2943493a73150246b |
| institution | Directory Open Access Journal |
| issn | 2348-3334 2348-506X |
| language | English |
| last_indexed | 2024-12-10T03:35:56Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | CHRISMED Journal of Health and Research |
| spelling | doaj.art-46b8796ea9ad4ef2943493a73150246b2022-12-22T02:03:42ZengWolters Kluwer Medknow PublicationsCHRISMED Journal of Health and Research2348-33342348-506X2014-01-0111363910.4103/2348-3334.126789Detection of subclinical anthracycline induced cardiotoxicity in breast cancer survivorsPreety NegiPamela Alice KingsleySandeep ChopraNavneet Kumar ChaudhryManmohan Krishan MahajanAims : To assess the chronic cardiac effects of anthracycline-based chemotherapy regimens on atrial and ventricular diameter, ejection fraction, and valvular abnormalities in relation to cumulative dose in breast cancer patients. Materials and Methods: Breast cancer patients who had received anthracycline-based chemotherapy and radiation therapy were enrolled. All patients had undergone a baseline and follow-up electrocardiogrphy, echocardiography, and clinical cardiac evaluation. Any changes in cardiac parameters were noted. Statistical Analysis Used: Statistical measures used were Chi-square test and independent t-test. Results: A total of 75 breast cancer patients were assessed. Out of these, 56 patients who received cumulative dose of doxorubicin ≥300 mg/m 2 showed increased cardiac dysfunction. Patients with left side breast cancer had greater cardiac abnormalities compared with right side. Conclusion: Cardiac dysfunction was significant with cumulative dose of doxorubicin ≥300 mg/m 2 and also was observed more in left side breast cancer patients.http://www.cjhr.org/article.asp?issn=2348-3334;year=2014;volume=1;issue=1;spage=36;epage=39;aulast=NegiAnthracyclinebreast cancercumulative dose |
| spellingShingle | Preety Negi Pamela Alice Kingsley Sandeep Chopra Navneet Kumar Chaudhry Manmohan Krishan Mahajan Detection of subclinical anthracycline induced cardiotoxicity in breast cancer survivors CHRISMED Journal of Health and Research Anthracycline breast cancer cumulative dose |
| title | Detection of subclinical anthracycline induced cardiotoxicity in breast cancer survivors |
| title_full | Detection of subclinical anthracycline induced cardiotoxicity in breast cancer survivors |
| title_fullStr | Detection of subclinical anthracycline induced cardiotoxicity in breast cancer survivors |
| title_full_unstemmed | Detection of subclinical anthracycline induced cardiotoxicity in breast cancer survivors |
| title_short | Detection of subclinical anthracycline induced cardiotoxicity in breast cancer survivors |
| title_sort | detection of subclinical anthracycline induced cardiotoxicity in breast cancer survivors |
| topic | Anthracycline breast cancer cumulative dose |
| url | http://www.cjhr.org/article.asp?issn=2348-3334;year=2014;volume=1;issue=1;spage=36;epage=39;aulast=Negi |
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