Echocardiographic Evidence of Early Diastolic Dysfunction in Asymptomatic Children with Osteogenesis Imperfecta
Objectives: Structural and functional cardiovascular abnormalities have been reported in adults with osteogenesis imperfecta (OI); however, there is a lack of paediatric literature on this topic. This study aimed to investigate cardiovascular abnormalities in children with OI in comparison to a cont...
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| Format: | Article |
| Language: | English |
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Sultan Qaboos University
2015-11-01
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| Series: | Sultan Qaboos University Medical Journal |
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| Online Access: | http://web.squ.edu.om/squmj/includes/tng/pub/tNG_download.asp?id=56509c109ef40e62b91fee215e2097ed |
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| author | Khalfan S. Al-Senaidi Irfan Ullah Hashim Javad Murtadha Al-Khabori Saif Al-Yaarubi |
| author_facet | Khalfan S. Al-Senaidi Irfan Ullah Hashim Javad Murtadha Al-Khabori Saif Al-Yaarubi |
| author_sort | Khalfan S. Al-Senaidi |
| collection | DOAJ |
| description | Objectives: Structural and functional cardiovascular abnormalities have been reported in adults with osteogenesis imperfecta (OI); however, there is a lack of paediatric literature on this topic. This study aimed to investigate cardiovascular abnormalities in children with OI in comparison to a control group. Methods: This
case-control study was conducted at the Sultan Qaboos University Hospital in Muscat, Oman, between May 2013 and August 2014. Data from eight patients with OI and 24 healthy controls were compared using conventional and tissue Doppler echocardiography (TDE). Results: The OI group had significantly lower peak early mitral valve flow velocity (P = 0.027), peak a-wave reversal in the pulmonary vein (P = 0.030) and peak early diastolic velocity of the mitral valve and upper septum (P = 0.001 each). The peak late diastolic velocities of the mitral valve (P = 0.002) and the upper septum (P = 0.037) were significantly higher in the OI group; however, the peak early/late diastolic velocity ratios of the mitral valve (P = 0.002) and upper septum (P = 0.001) were significantly lower. Left ventricular dimensions and aortic and pulmonary artery diameters were larger in the OI group when indexed for body surface area. Both groups had normal systolic cardiac function. Conclusion: Children with OI had normal systolic cardiac function. However, changes in myocardial tissue Doppler velocities were suggestive of early diastolic cardiac
dysfunction. They also had increased left ventricular dimensions and greater vessel diameters. These findings indicate the need for early and detailed structural and functional echocardiographic assessment and follow-up of young patients with OI. |
| first_indexed | 2024-12-22T22:57:48Z |
| format | Article |
| id | doaj.art-46bb4d42164b487b8c68558f02def6f8 |
| institution | Directory Open Access Journal |
| issn | 2075-051X 2075-0528 |
| language | English |
| last_indexed | 2024-12-22T22:57:48Z |
| publishDate | 2015-11-01 |
| publisher | Sultan Qaboos University |
| record_format | Article |
| series | Sultan Qaboos University Medical Journal |
| spelling | doaj.art-46bb4d42164b487b8c68558f02def6f82022-12-21T18:09:46ZengSultan Qaboos UniversitySultan Qaboos University Medical Journal2075-051X2075-05282015-11-01154e45646210.18295/squmj.2015.15.04.003Echocardiographic Evidence of Early Diastolic Dysfunction in Asymptomatic Children with Osteogenesis ImperfectaKhalfan S. Al-Senaidi0Irfan Ullah1Hashim Javad2Murtadha Al-Khabori3Saif Al-Yaarubi4Department of Child Health, Sultan Qaboos University Hospital, Muscat, OmanDepartment of Child Health, Sultan Qaboos University Hospital, Muscat, OmanDepartment of Child Health, Sultan Qaboos University Hospital, Muscat, OmanDepartment of Haematology, Sultan Qaboos University Hospital, Muscat, OmanDepartment of Child Health, Sultan Qaboos University Hospital, Muscat, OmanObjectives: Structural and functional cardiovascular abnormalities have been reported in adults with osteogenesis imperfecta (OI); however, there is a lack of paediatric literature on this topic. This study aimed to investigate cardiovascular abnormalities in children with OI in comparison to a control group. Methods: This case-control study was conducted at the Sultan Qaboos University Hospital in Muscat, Oman, between May 2013 and August 2014. Data from eight patients with OI and 24 healthy controls were compared using conventional and tissue Doppler echocardiography (TDE). Results: The OI group had significantly lower peak early mitral valve flow velocity (P = 0.027), peak a-wave reversal in the pulmonary vein (P = 0.030) and peak early diastolic velocity of the mitral valve and upper septum (P = 0.001 each). The peak late diastolic velocities of the mitral valve (P = 0.002) and the upper septum (P = 0.037) were significantly higher in the OI group; however, the peak early/late diastolic velocity ratios of the mitral valve (P = 0.002) and upper septum (P = 0.001) were significantly lower. Left ventricular dimensions and aortic and pulmonary artery diameters were larger in the OI group when indexed for body surface area. Both groups had normal systolic cardiac function. Conclusion: Children with OI had normal systolic cardiac function. However, changes in myocardial tissue Doppler velocities were suggestive of early diastolic cardiac dysfunction. They also had increased left ventricular dimensions and greater vessel diameters. These findings indicate the need for early and detailed structural and functional echocardiographic assessment and follow-up of young patients with OI.http://web.squ.edu.om/squmj/includes/tng/pub/tNG_download.asp?id=56509c109ef40e62b91fee215e2097edChildrenOsteogenesis ImperfectaCardiovascular AbnormalitiesDoppler Echocardiography |
| spellingShingle | Khalfan S. Al-Senaidi Irfan Ullah Hashim Javad Murtadha Al-Khabori Saif Al-Yaarubi Echocardiographic Evidence of Early Diastolic Dysfunction in Asymptomatic Children with Osteogenesis Imperfecta Sultan Qaboos University Medical Journal Children Osteogenesis Imperfecta Cardiovascular Abnormalities Doppler Echocardiography |
| title | Echocardiographic Evidence of Early Diastolic Dysfunction in Asymptomatic Children with Osteogenesis Imperfecta |
| title_full | Echocardiographic Evidence of Early Diastolic Dysfunction in Asymptomatic Children with Osteogenesis Imperfecta |
| title_fullStr | Echocardiographic Evidence of Early Diastolic Dysfunction in Asymptomatic Children with Osteogenesis Imperfecta |
| title_full_unstemmed | Echocardiographic Evidence of Early Diastolic Dysfunction in Asymptomatic Children with Osteogenesis Imperfecta |
| title_short | Echocardiographic Evidence of Early Diastolic Dysfunction in Asymptomatic Children with Osteogenesis Imperfecta |
| title_sort | echocardiographic evidence of early diastolic dysfunction in asymptomatic children with osteogenesis imperfecta |
| topic | Children Osteogenesis Imperfecta Cardiovascular Abnormalities Doppler Echocardiography |
| url | http://web.squ.edu.om/squmj/includes/tng/pub/tNG_download.asp?id=56509c109ef40e62b91fee215e2097ed |
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